Induction of growth suppression and modification of gene expression in multi‐drug‐resistant human glioblastoma multiforme cells by recombinant human fibroblast and immune interferon

Moulton, Thomas; Jiang, Hai; Guarini, L; Fetell, Michael R.; Fisher, Paul B.

doi:10.1002/ijc.2910510307

Cited by 5 publications

(2 citation statements)

References 21 publications

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“…1) IFN-b is known to have a differentiating effect on malignant tumors. 13,21) Neurophysiological mapping and monitoring are essential for brain stem surgery. Facial nerve mapping and brain stem auditory-evoked potential monitoring are commonly used in approaches through the floor of the fourth ventricle.…”

Section: Discussionmentioning

confidence: 99%

Biopsy of Brain Stem Glioma Using Motor-Evoked Potential Mapping by Direct Peduncular Stimulation and Individual Adjuvant Therapy-Case Report-

Tanaka

Kobayashi

Utsuki

et al. 2005

Neurol. Med. Chir.(Tokyo)

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A 23-year-old man presented with a brain stem glioma manifesting as a 6-month history of right hemiparesis and diplopia. Serial magnetic resonance imaging showed an intrinsic diffuse brain stem glioma that gradually localized to the left cerebral peduncle after initial adjuvant therapy. Surgery was performed through a left subtemporal transtentorial approach under motor-evoked potential (MEP) mapping by direct peduncular stimulation. The lateral aspect of the midbrain was exposed, a train of five bipolar 25 mA pulses was applied, and MEPs recorded from the extremities. MEPs were only recorded from the left extremities even with left cerebral peduncular stimulation. Partial resection of the tumor was safely performed, with slight temporary neurological worsening. The histological diagnosis was anaplastic astrocytoma. Individual adjuvant therapy based on the results of real-time reverse transcription-polymerase chain reaction of O 6 -methylguanine-deoxyribonucleic acid methyltransferase achieved an almost complete tumor response. Surgery under pyramidal tract mapping and intensive postoperative adjuvant therapy resulted in a good outcome despite the presence of a generally intractable intrinsic brain stem glioma.

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Section: Discussionmentioning

confidence: 99%

Biopsy of Brain Stem Glioma Using Motor-Evoked Potential Mapping by Direct Peduncular Stimulation and Individual Adjuvant Therapy-Case Report-

Tanaka

Kobayashi

Utsuki

et al. 2005

Neurol. Med. Chir.(Tokyo)

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“…These antiviral proteins are produced by infected cells and lead to the synthesis of cell proteins, which halt viral replication, and also shape the adaptive immune response by priming T cells. Additionally, interferons also modulate a plethora of other important cellular functions including cell growth and differentiation, histocompatibility and tumor antigen expression, gene expression and anti-tumor effects (Fisher, et al, 1983; Fisher & Grant, 1984; Giacomini, et al, 1984; Grant, et al, 1985; Greiner, et al, 1984; Huang, et al, 1999a; Huang, et al, 1999b; Jiang, et al, 2000; Moulton, et al, 1992; Sen & Sarkar, 2007; Su, et al, 2008). …”

Section: Introductionmentioning

confidence: 99%

Functions of the cytoplasmic RNA sensors RIG-I and MDA-5: Key regulators of innate immunity

Barral

Sarkar

et al. 2009

Pharmacology & Therapeutics

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165

131

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The innate immune system responds within minutes of infection to produce type I interferons and pro-inflammatory cytokines. Interferons induce the synthesis of cell proteins with antiviral activity, and also shape the adaptive immune response by priming T cells. Despite the discovery of interferons over 50 years ago, only recently have we begun to understand how cells sense the presence of a virus infection. Two families of pattern recognition receptors have been shown to distinguish unique molecules present in pathogens, such as bacterial and fungal cell wall components, viral RNA and DNA, and lipoproteins. The first family includes the membrane-bound toll-like receptors (TLRs). Studies of the signaling pathways that lead from pattern recognition to cytokine induction have revealed extensive and overlapping cascades that involve protein-protein interactions and phosphorylation, and culminate in activation of transcription proteins that control the transcription of genes encoding interferons and other cytokines. A second family of pattern recognition receptors has recently been identified, which comprises the cytoplasmic sensors of viral nucleic acids, including MDA-5, RIG-I, and LGP2. In this review we summarize the discovery of these cytoplasmic sensors, how they recognize nucleic acids, the signaling pathways leading to cytokine synthesis, and viral countermeasures that have evolved to antagonize the functions of these proteins. We also consider the function of these cytoplasmic sensors in apoptosis, development and differentiation, and diabetes.

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Effect of intraperitoneal chemotherapy and fibrinolytic therapy on tumor implantation in wound sites

et al. 1996

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Failure of surgical treatment for gastrointestinal cancers is often caused by recurrence of the tumor in traumatized peritoneal surfaces. This study examined the effect of intraperitoneal administration of doxorubicin and recombinant tissue plasminogen activator (rt‐PA), a fibrinolytic agent, on incidence and volume of postoperative tumor implants in peritoneal wounds. Prior to randomization, a surgical wound was created on the right parietal peritoneum of 110 BDIX rats and 6 × 105 DHD/K12 colon cancer cells were inoculated intraperitoneally (ip). The control group was given an intraperitoneal injection of saline. Five groups received 1 mg/kg of ip doxorubicin at different times postoperatively: at the end of surgery (DO), 3 hr after surgery (D + 3), postoperative day 1 (Dl), postoperative day 3 (D3), and postoperative day 7(D7). In a second set of experiments, five groups of rats received, in addition to postoperative doxorubicin, 5 mg/kg of intraoperative ip rt‐PA. Incidence and volume of tumor implants in peritoneal wounds were assessed for each group 20 days after the tumor inoculation. All rats of the control group (incidence = 100%) developed tumor implants in peritoneal wounds. Mean (SD) volume was 16.2 (4.7) mm3. When administered at DO, D + 3, and Dl intraperitoneal doxorubicin reduced significantly the incidence and volume of tumor implants in wounds. Postoperative administration of doxorubicin at D3 and D7 did not affect significantly the incidence and the volume of tumor implants in peritoneal wounds. When rt‐PA was administered intraoperatively, ip injection of doxorubicin at any postoperative timing decreased significantly the incidence and volume of tumor implants. In conclusion, ip doxorubicin administered before postoperative D3 may act on tumor cell implanted in peritoneal wounds. Delayed (D3, D7) ip administration of doxorubicin does not prevent the development of tumor implants in peritoneal wounds. Intraoperative administration of rt‐PA may significantly increase the efficacy of delayed ip chemotherapy. © 1996 Wiley‐Liss, Inc.

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Induction of growth suppression and modification of gene expression in multi‐drug‐resistant human glioblastoma multiforme cells by recombinant human fibroblast and immune interferon

Cited by 5 publications

References 21 publications

Biopsy of Brain Stem Glioma Using Motor-Evoked Potential Mapping by Direct Peduncular Stimulation and Individual Adjuvant Therapy-Case Report-

Biopsy of Brain Stem Glioma Using Motor-Evoked Potential Mapping by Direct Peduncular Stimulation and Individual Adjuvant Therapy-Case Report-

Functions of the cytoplasmic RNA sensors RIG-I and MDA-5: Key regulators of innate immunity

Effect of intraperitoneal chemotherapy and fibrinolytic therapy on tumor implantation in wound sites

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