Induction of hepatic microsomal enzymes by Aroclor® 1254 inIctalurus punctatus (channel catfish)

Cytological and Biochemical Effects of a Mixture of 20 Pollutants on Isolated Rainbow Trout (Oncorhynchus mykiss) Hepatocytes

“…PCBs, as major components of the chemical mixture investigated (Honnen et al, 2001), are known to accumulate in (Zitko and Hutzinger, 1976) and to be metabolized (Melancon and Lech, 1976) by "sh liver, correlating with an induction of the microsomal mixed-function oxygenase system (MFO) (Lidmann et al, 1976;Hill et al, 1976;Lipsky et al, 1978). Elangbam and colleagues (1991) reported that hepatocytes of wild cotton rats displayed increased cytoplasmic lipid droplets after exposure to a PCB-contaminated habitat.…”

Xenobiotic monooxygenase activity and the response to inducers of cytochrome P-450 during embryonic and larval development in fish

“…Yarbrough and Chambers, 1977). Additionally, PCBs have been reported to induce aminopyrine N-demethylase in channel catfish and mullet, Chelon labrosus (Hill and Camp, 1976;Narbonne and Gallis, 1979). Whether these species can respond to PB-type inducers has not been examined.…”

Relationship between biotransformation and the toxicity and fate of xenobiotic chemicals in fish.

“…investigation that compounds such as benzo(a)pyrene and 3-methylcholanthrene, inducers of Pi-450 cytochrome(s) in mammals, are capable of elevating mixed-function oxidase activity from 10 to 50-fold in several species of fish (12)(13)(14)(15)(52)(53)(54)(55)(56). Figure 9 illustrates the effect of phenobarbital, 3methylcholanthrene, benzanthracene, and f3-naphthoflavone on the specific activity of glucose-6phosphatase, a microsomal marker enzyme, glucuronyl transferase, and benzo(a)pyrene hydroxylase in microsomes prepared from liver of rainbow trout treated with these compounds.…”