Induction of human ovulation by individualized gonadotrophin therapy in two phases

A Case Who Became Pregnant With Symptom of Acute Abdomen as the Result of Ovulation Induced With PMS and HCG

“…In recent days, treatments are generally made along this line. (1942), Rydberg and Pedersen-Bejygaad (1943), Hamblen and Davis (1945), Westman (1940), Staemmler (1956) and Igarashi and Matsumoto (1957) reported their respective devices and results of applications. However, despite their theoretical plausibility, practical results in pregnancy rate are not always statisfactory.…”

“…In view of low urinary 17-OHCS level evidenced in them, 10 units of ACTH was intramuscularly given every other day from April 26 to June 21, 1963, but the administration was discontinued since no remarkable change was observed either in BBT or in cervical mucus. So gonadotrophin therapy according to ITP method (Igarashi et al, 1957) was started on June 25 ( Fig.1). First, PMS (Serotropin, Teikoku Hormone Mfg., Tokyo) was intramuscularly injected for 9days in a daily dose of 1,000 I.U., and cervical mucus was subsequently increased to 600cmm.…”

Induction of Ovulation in the Human-Older and Newer Approaches

“…Successful results with PMS and HCG have been reported by a number of other workers. In particular, the paper by Igarashi & Matsumoto (1957) from Japan is of considerable interest. These authors stress the need for individualized therapy and regard the quantity of cervical secretion as the best guide to follicle maturity, though unfortunately they do not give details as to how this measurement was made.…”

Προκλησις Ωοτοκιας Δι'ανθρωπινων Γοναδοτροφινων Και Clomiphene Citrate

“…(Hamblen και Davis 16 , Rydberg και συν. 17 , Riisfeldt 18 , Igarashi και Matsumoto 19 ). Tò γεγρνάς άτι ό Müller 20 ήδυνήθη να συλλέξη 39 περι πτώσεις έκ τής βιβλιογραφίας, αίτινες ένεφάνισαν το σύνδρομον ύπερδιεγέρσεως τών ωοθηκών, δηλοΐ ότι ή μορφή αΰτη θεραπείας δέν ήτο άμοιρος συνεπειών δια τήν άνθρωπίνην ώοθήκην.…”

“…Ή συχνότης εκδηλώσεως του συνδρόμου ύπερδιεγέρσεως τών ωο θηκών ανήλθε, μεταξύ τών περιπτώσεων τών θεραπευθεισών δια γοναδο τροφινών, εις 7 %, ενώ δια τάς περιπτώσεις τάς θεραπευθείσας δια Clomi phene εις 2 %. 19. Πέντε εκ τών κυήσεων έπεπλάκησαν δια του συνδρόμου ύπερδιε γέρσεως τών ωοθηκών.…”