Induction of human sulfotransferase 1A3 (SULT1A3) by glucocorticoids

Bian, Hao; Ngo, Sherry; Tan, Wui-Gee; Wong, Christina; Boelsterli, Urs A.; Tan, Theresa May Chin

doi:10.1016/j.lfs.2007.09.029

Cited by 20 publications

(13 citation statements)

References 47 publications

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“…Other DMPs of interest, below multiple comparison corrections, were located in genes such as KCNAB2 (cg13614083; p = 5.34 × 10 −6 ) and CACNA1B (cg02849279; p = 8.08 × 10 −6 ), coding for a voltage‐gated potassium and calcium channel, respectively. Both channels regulate neurotransmitter release and neuronal excitability (Lipscombe, Allen, & Toro, ; Schultz, Litt, Smith, Thayer, & McCormack, ), and SULT1A3 (cg06291594; p = 5.10 × 10 −6 ), involved in dopamine metabolism and response to glucocorticoids (Bian et al., ; Sidharthan, Minchin, & Butcher, ). Interestingly, another DMP on chromosome 11 (cg07934552; p = 2.95 × 10 −6 ) was found in the proximity of binding sites for several transcription factors, including NR3C1 , which is also associated with glucocorticoid response (Oberlander et al., ).…”

Section: Resultsmentioning

confidence: 99%

“…SULT1A3 is also highly expressed in temporal structures such as the hippocampus (Salman, Kadlubar, & Falany, ). This protein is involved in dopamine metabolism (Sidharthan et al., ) and has been shown to respond to glucocorticoids (Bian et al., ). Glucocorticoids play a key role in risk for psychological syndromes such as depression, anxiety, and antisocial behavior (Haller, ) and are also strongly responsive to environmental factors such as stress (McEwen et al., ).…”

Section: Discussionmentioning

confidence: 99%

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Longitudinal epigenetic predictors of amygdala:hippocampus volume ratio

Walton

Cecil

Suderman

et al. 2017

Child Psychology Psychiatry

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Background The ratio between amygdala:hippocampal (AH) volume has been associated with multiple psychiatric problems, including anxiety and aggression. Yet, little is known about its biological underpinnings. Here, we used a methylome-wide approach to test (1) whether DNA methylation in early life (birth, age 7) prospectively associates with total AH volume ratio in early adulthood, and (2) whether significant DNA methylation markers are influenced by prenatal risk factors. Methods Analyses were based on a subsample (n = 109 males) from the Avon Longitudinal Study of Parents and Children (ALSPAC), which included measures of prenatal risk, DNA methylation (Infinium Illumina 450k), T1-weighted brain scans and psychopathology in early adulthood (age 18-21). Amygdala and hippocampus measures were derived using Freesurfer 5.3.0. Methylation markers related to AH volume ratio across time were identified using longitudinal multi-level modeling. Results AH volume ratio correlated positively with age 18 psychosis-like symptoms (p = 0.007). Methylation of a probe in the gene SP6 associated longitudinally with (1) higher AH volume ratio (FDR q-value = 0.01) and (2) higher stressful life events during pregnancy (p = 0.046). SP6 is expressed in the hippocampus and amygdala and has been implicated in cognitive decline in Alzheimer's disease. The association between SP6 DNA methylation, AH volume ratio and psychopathology was replicated in an independent dataset of 101 patients with schizophrenia and 111 healthy controls. Conclusions Our findings suggest that epigenetic alterations in genes implicated in neurodevelopment may contribute to a brain-based biomarker of psychopathology.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Longitudinal epigenetic predictors of amygdala:hippocampus volume ratio

Walton

Cecil

Suderman

et al. 2017

Child Psychology Psychiatry

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“…Coactivators bound to glucocorticoid receptors are known as SRC-1/CBP/p300/pCAF complexes, Rap46, RSP5/RPF1, and SWI/SNF family complexes (8,22). Glucocorticoid-GR complexes bound to coactivators induce transcriptional activation of SULT1A1 and SULT1A3, cytosolic aryl sulfotransferases for detoxication as well as to regulate the expression of the Ucp3 gene in response to stress (23)(24)(25). In the present study, we show that the expression of mPon2 as an antioxidant enzyme against cellular oxidative stress is also induced by glucocorticoids.…”

Section: Discussionmentioning

confidence: 99%

Transcriptional activation of an anti-oxidant mouse Pon2 gene by dexamethasone

Lim

Kim

2009

BMB Reports

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Glucocorticoids regulate multiple physiological processes such as metabolic homeostasis and immune response. Mouse Pon2 (mPon2) acts as an antioxidant to reduce cellular oxidative stress in cells. In this present study, we investigated the transcriptional regulation of mPon2 by glucocorticoids. In the presence of glucocorticoid analogue dexamethasone, the expression of mPon2 mRNA in cells was increased, whereas the expression was inhibited by a transcription inhibitor actinomycin D. Glucocorticoid receptors bound to the putative glucocorticoid response elements located between -593 bp and -575 bp of the mPon2 promoter. Transcriptional activity was completely blocked when the putative element was mutated. Taken together, these results suggest that the expression of the mPon2 gene is directly regulated by glucocorticoid-glucocorticoid receptor complexes.[BMB reports 2009; 42(7): 421-426]

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“…SULT1A3 can be induced by glucocorticoids [15] and all subjects in this study were using inhaled corticosteroids. Subjects were excluded from the study if it was judged by the clinic respiratory physician that short-acting β 2 -agonists were likely to be required before or during this sampling period.…”

Section: Drug Administration and Sample Collectionmentioning

confidence: 99%

SULT 1A3 single‐nucleotide polymorphism and the single dose pharmacokinetics of inhaled salbutamol enantiomers: Are some athletes at risk of higher urine levels?

Jacobson

Yee

Wood‐Baker

et al. 2014

Drug Testing and Analysis

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The study was designed to investigate the effect of a common genetic variation of the main salbutamol metabolizing enzyme SULT1A3 (single nucleotide polymorphism 105A>G, rs1975350) on the stereoselective pharmacokinetics of salbutamol. Subjects were administered a 400 µg dose of inhaled salbutamol via a large volume spacer and blood samples were collected over 4 h. Plasma levels of (R)- and (S)-salbutamol were determined by an enantioselective liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay. Twenty-five subjects with asthma were recruited and underwent SULT1A3 genotyping, from which four SNP homozygote (GG) subjects and nine wild-type (AA) subjects were selected to participated in the pharmacokinetic investigation. There were no differences in pharmacokinetic parameters (t1/2 , Cmax , AUC0-4h ) between SNP and wild-type genotypes for either the R- or S-enantiomer. Observed Cmax of R- and S-salbutamol [mean (SD)] was 0.64 (0.30) ng/mL and 1.32 (0.98) ng/mL, respectively. The mean t1/2 of R- and S-salbutamol was estimated at 2.94 (1.17) h and 7.86 (6.14) h respectively. The AUC0-4h of R- and S-salbutamol was 14.0 (6.8) and 38.3 (19.5) ng/mL.h respectively. In conclusion, the common SULT1A3 SNP 105A>G is not an important determinant of salbutamol enantiomer pharmacokinetics under normal clinical use and does not place some individuals at greater risk of accumulation in the body.

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Induction of human sulfotransferase 1A3 (SULT1A3) by glucocorticoids

Cited by 20 publications

References 47 publications

Longitudinal epigenetic predictors of amygdala:hippocampus volume ratio

Longitudinal epigenetic predictors of amygdala:hippocampus volume ratio

Transcriptional activation of an anti-oxidant mouse Pon2 gene by dexamethasone

SULT 1A3 single‐nucleotide polymorphism and the single dose pharmacokinetics of inhaled salbutamol enantiomers: Are some athletes at risk of higher urine levels?

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