Induction of hypoxia inducible factor 1α by Toll-like receptors in human dendritic cells

Djafarzadeh, Siamak; Spirig, Rolf; Regueira, Tomás; Takala, Jukka; Scholbach, Jakob; Rieben, Robert; Lepper, PM

doi:10.1186/cc6607

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Biochemical Mechanisms Leading To the Accumulation/ Activati1

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2010

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“…At the moment, two types of membrane-associated TLRs (TLR4 and TLR2) are known to induce the accumulation of HIF-1a (Blouin et al 2004;Djafarzadeh et al 2008;Frede et al 2006;Sumbayev 2008a). In addition, it was recently reported that HIF-1a coordinates the induction of TLR2 and TLR6 during hypoxia (Kuhlicke et al 2007).…”

Section: Biochemical Mechanisms Leading To the Accumulation/ Activatimentioning

confidence: 99%

Hypoxia-inducible Factor 1 as one of the “Signaling Drivers” of Toll-like Receptor-Dependent and Allergic Inflammation

Sumbayev

Nicholas

2010

Arch. Immunol. Ther. Exp.

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Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription complex which plays a crucial role in cellular adaptation to low oxygen availability. In the last years there has been increasing evidence about the role of this factor in inflammatory/innate immune reactions. It has also been found to contribute to different types of allergic inflammation. In this review the current knowledge about the accumulation and role of HIF-1 in Toll-like receptor-mediated and allergic inflammation is summarized. Differential biochemical mechanisms employed to stabilize the protein in different cases are discussed.

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Section: Biochemical Mechanisms Leading To the Accumulation/ Activatimentioning

confidence: 99%

Hypoxia-inducible Factor 1 as one of the “Signaling Drivers” of Toll-like Receptor-Dependent and Allergic Inflammation

Sumbayev

Nicholas

2010

Arch. Immunol. Ther. Exp.

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show abstract

Induction of hypoxia inducible factor 1α by Toll-like receptors in human dendritic cells

Cited by 1 publication

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Hypoxia-inducible Factor 1 as one of the “Signaling Drivers” of Toll-like Receptor-Dependent and Allergic Inflammation

Hypoxia-inducible Factor 1 as one of the “Signaling Drivers” of Toll-like Receptor-Dependent and Allergic Inflammation

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