Induction of in vitro EROD activity and in vivo caffeine metabolism in two species of New Zealand birds

Numata, Mihoko; Fawcett, J. Paul; Rosengren, Rhonda J.

doi:10.1016/j.etap.2007.11.005

Cited by 5 publications

(1 citation statement)

References 27 publications

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“…Earlier publications have developed methods for the determination of purine alkaloids in plasma using RP-HPLC [9,10]. But most reports seemed to be lack of the information on the identification of the analytes and the dynamic changes among the analytes after oral administration of the single substances and the plant.…”

Section: Introductionmentioning

confidence: 99%

Identification and dynamic analysis of the purine alkaloids in rat plasma after oral administration of green tea by liquid chromatography hybrid ion trap time-of-flight mass spectrometry

Song

Wang

et al. 2012

Journal of Chromatography B

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Section: Introductionmentioning

confidence: 99%

Identification and dynamic analysis of the purine alkaloids in rat plasma after oral administration of green tea by liquid chromatography hybrid ion trap time-of-flight mass spectrometry

Song

Wang

et al. 2012

Journal of Chromatography B

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Disposition Kinetics of Caffeine and Paraxanthine in Nile Tilapia (Oreochromis niloticus): Characterization of the Main Metabolites

Gómez-Martínez

2010

Arch Environ Contam Toxicol

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The reproductive and developmental toxicities of caffeine (CA) reported in mammals have been linked with the characteristics of its kinetic disposition. Because undesirable reproductive effects in fish have also been reported, and considering that CA has been found worldwide at relatively high concentrations in most bodies of waters, this study evaluated the disposition kinetics of CA and its main metabolite paraxanthine (1,7-dimethylxanthine; PX) in Nile tilapia after a single intraperitoneal administration (4 mg/kg). CA showed rapid absorption, first-order elimination with biexponential decay, rapid intercompartmental transfer, wide distribution in almost the entire body water (apparent volume of distribution [Vd(ss)] 0.45 l/kg), terminal elimination half-life (t(1/2) (β)) 4.08 h, and systemic clearance (Cl) 0.75 ml/min/kg; there were no important differences between parameters determined in plasma or in other organs (liver and gills). PX was rapidly formed in liver, showing saturable-kinetic properties in this organ, with V(max) 8.11 μg/g h and K(m) 12.58 μg/g. The terminal elimination linear process was similar between matrices, with a half-life (t(1/2 el)) 2.12 h, Vd(ss) 0.35 l/kg, and Cl 1.24 ml/min/kg. CA in tilapia was extensively metabolized to 1-methyl-uric acid and 1-methyl-xanthine in all of the organs studied. Metabolic and kinetic patterns were comparable with those reported for mammals. The observation of a concentration-dependent kinetic of PX is an important finding. Thus, toxicities of CA in fish would appear to be similar to those in mammals and should be considered in the risk assessments for this species, especially during the early stages of development.

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Charting a path towards non-destructive biomarkers in threatened wildlife: A systematic quantitative literature review

Chaousis

Leusch

Merwe

2018

Environmental Pollution

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Induction of in vitro EROD activity and in vivo caffeine metabolism in two species of New Zealand birds

Cited by 5 publications

References 27 publications

Identification and dynamic analysis of the purine alkaloids in rat plasma after oral administration of green tea by liquid chromatography hybrid ion trap time-of-flight mass spectrometry

Identification and dynamic analysis of the purine alkaloids in rat plasma after oral administration of green tea by liquid chromatography hybrid ion trap time-of-flight mass spectrometry

Disposition Kinetics of Caffeine and Paraxanthine in Nile Tilapia (Oreochromis niloticus): Characterization of the Main Metabolites

Charting a path towards non-destructive biomarkers in threatened wildlife: A systematic quantitative literature review

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