Induction of interferon in ovine and human lymphocyte cultures by mycoplasmas

Cole, Barry C.; Overall, James C.; Lombardi, P.; Glasgow, Lowell A.

doi:10.1128/iai.14.1.88-94.1976

Cited by 47 publications

(13 citation statements)

References 19 publications

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“…In addition, the persisting high levels of complement-fixing antibody after a single injection of organisms were not consistent with an immunosuppressive response. Furthermore, it has also been shown that viable M. arthritidis is capable of inducing interferon in vivo after injection into mice (27) and in vitro when added to sheep or human lymphocyte cultures (11). More recently, M. pulmonis (9, 21) and M. pneumoniae (4) (glucose utilizers) have been reported to be mitogenic for normal lymphocytes, and additional studies in our laboratories suggest that a wide range of species exhibit this property (7).…”

Section: Discussionmentioning

confidence: 97%

Mycoplasma-dependent activation of normal lymphocytes: induction of a lymphocyte-mediated cytotoxicity for allogeneic and syngeneic mouse target cells

Aldridge¹,

Cole²,

Ward³

1977

Infect Immun

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Mycoplasma arthritidis, M. hominis, and M. arginini were tested for their ability to induce a cytotoxic response from normal CBA mouse lymphocytes against 5"Cr-labeled allogeneic and syngeneic target cells. In most cases, the mycoplasmas alone were not toxic for the target cells. Furthermore, the mycoplasmas did not result in decreased lymphocyte viability but, in fact, contributed to enhanced lymphocyte survival. In the absence of normal CBA lymphocytes, mycoplasmas alone did not induce a significant amount of cell damage in either the allogeneic or the syngeneic target cells. Strains of M. arthritidis and M. hominis, when added to the lymphocyte-target cell mixtures, induced statistically significant increases in 51Cr release from both target cell types at each assay period after 6 h. The release of 5"Cr was taken as a measure of cell death. M. arginini induced only low levels of cytotoxicity or none at all. Both arthritogenic and non-arthritogenic strains of M. arthritidis induced the cytotoxic response. The degree of cytotoxicity produced was directly related to the size of the initial inoculum. The presence or absence of serum in the culture medium did not contribute significantly to the cytotoxicity response.

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Section: Discussionmentioning

confidence: 97%

Mycoplasma-dependent activation of normal lymphocytes: induction of a lymphocyte-mediated cytotoxicity for allogeneic and syngeneic mouse target cells

Aldridge¹,

Cole²,

Ward³

1977

Infect Immun

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“…Cole et al (7) have reported that IFN was induced by M. pneumoniae and M. synovie in human lymphocyte cultures, but not by M. salivarium, M. orale, M. gallisepticum and A. laidlawii. They observed a marked variation in the levels of IFN induced by mycoplasmas in lymphocytes from the same donor on different occasions and from different donors in the same experiment.…”

Section: Discussionmentioning

confidence: 99%

Induction of Cytokines in Human Peripheral Blood Mononuclear Cells by Mycoplasmas

Kita

Ohmoto

Hirai

et al. 1992

Microbiology and Immunology

118

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“…Mycoplasma membrane lipoproteins may induce the production of proinflammatory cytokines; M. fermentans lipoproteins induce them by stimulation of tyrosine phosphorylation in human monocytes (27). M. synoviae has strong mitogenic activity on mouse lymphocytes and stimulates human lymphocytes to produce interferon (11,13), but it is not known by which component(s). We found that M. synoviae membranes as well as proteins secreted into growth medium have a considerable mitogenic activity in vitro for mouse lymphocytes and chicken thymocytes.…”

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The Hemagglutination-Positive Phenotype ofMycoplasma synoviaeInduces Experimental Infectious Synovitis in Chickens More Frequently than Does the Hemagglutination-Negative Phenotype

et al. 1998

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Inoculation with hemagglutination-positive (HA+) cultures of Mycoplasma synoviae AAY-4 induced acute synovitis significantly more frequently (P = 0.001) in chicken tibiotarsal-tarsometatarsal joints than did inoculation with HA-negative (HA−) cultures derived from the same clone of AAY-4. Immunoblotting analyses showed that HA+ cultures abundantly expressed two phase-variable hemadherence-associated surface membrane proteins of 53 kDa and 48 to 50 kDa defined by monoclonal antibodies. HA− cultures lacked the 53-kDa proteins and synthesized truncated 27- to 30-kDa forms of the 48- to 50-kDa proteins. Inoculation of cyclosporin A (CsA) into infected joints significantly decreased the frequency of acute synovitis (P = 0.001). Moreover, repeated intra-articular inoculation of CsA (three doses of 1 mg at 2-day intervals) significantly reduced the local antibody response to M. synoviae in the joints treated with CsA.

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Induction of interferon in ovine and human lymphocyte cultures by mycoplasmas

Cited by 47 publications

References 19 publications

Mycoplasma-dependent activation of normal lymphocytes: induction of a lymphocyte-mediated cytotoxicity for allogeneic and syngeneic mouse target cells

Mycoplasma-dependent activation of normal lymphocytes: induction of a lymphocyte-mediated cytotoxicity for allogeneic and syngeneic mouse target cells

Induction of Cytokines in Human Peripheral Blood Mononuclear Cells by Mycoplasmas

The Hemagglutination-Positive Phenotype ofMycoplasma synoviaeInduces Experimental Infectious Synovitis in Chickens More Frequently than Does the Hemagglutination-Negative Phenotype

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