“…Vaginal administration of the synthetic prostaglandin misoprostol, often in the form of fractionated tablet doses (25 µg) of the anti-ulcer product Cytotec ® , has also been widely reported for cervical ripening (Furukan et al, 2007;Rodrigues et al, 1998;Sanchez-Ramos et al, 1998;Sharma et al, 2005;Zieman et al, 1997). As with dinoprostone, a hydrogel insert for sustained-release vaginal administration of misoprostol has also been developed, marketed under the brand names Mysodelle ® /Myspess ® /Misodel ® and offering administration rates of approximately 7 g/h misoprostol (Miller et al, 2016;Powers et al, 2008;Stephenson and Wing, 2015;Wing, 2008;Wing et al, 2013).…”