Induction of labour by intra-amniotic hypertonic saline.

Abstract

BDI&ARLJShRNAL 327 300 mg. or less. The activity lay within the normal range and did not correlate with cholesterol levels.Atromid-S (clofibrate) lowered the serum cholesterol significantly in 15 of the patients compared with 15 controls.Fibrinolytic activity did not change significantly in either treated or control groups.These results are in striking contrast with those of a previous trial involving patients with hypercholesterolaemia.

Professor Eugen Aburel, an original Romanian Contributor to modern Obstetrics and Gynecology

“…From these researches an original procedure resulted -i.e., a means of inducing birth through intra-amniotic injections of excitomotor substances. Rapidly spread to many countries, Aburel's technique of intra-amniotic injection of hypersaline solution was first presented in a communication at the Society of Physicians and Naturalists in Iasi in 1934 (62).It was then published in that Society`s Journal in 1939. (63) The procedure was intended to trigger uterine contraction and expulsion of the product of conception, a dead fetus.…”

Termination of Pregnancy with Intra-amniotic Hypertonic Saline

“…The technique, originally described by Aburel (1934), has been widely used in Scandinavia to induce midtrimester abortions (Wagner et al, 1962) and to investigate the mechanism of onset of labour (Bengtsson and Csapo, 1962). In Britain the use of both hypertonic glucose and hypertonic saline in cases of missed abortion or (Wood et al, 1962;Millar and Harvey, 1966). Hypertonic saline, however, has not been popular because of the reports of several deaths following its use (Wagatsuma, 1965;Cameron and Dayan, 1966;Frost, 1968;Cameron et al, 1969).…”