Induction of Labour With Misoprostol – A Prostaglandin E1 Analogue

Abstract

The purpose of our stud y was to compare the safety and efficacy of intravaginal misoprostol versus existing hospital protocol of intracervical dinoprostone and oxytocin for cervical ripening and induction of labour. 200 patients with indication for induction of labour were randomly assigned to recei ve either intravaginal misoprostol or dinoprostone/oxytccin combination. In first group twenty five micrograms of misoprostol was placed intravaginally every 6 hours tiII the patient reached active stage of labour. In second group dinoprostone gel 0.5 mg was placed in the endocervix at night and oxytocin induction was started in the early morning. The average interval from start to induction of vaginal delivery was shorter in misoprostol group (1315±811 minutes) compared to dinoprostone/oxytocin group (1512±712 minutes) (p < 0.01) . There was no significant difference in route of delivery.18% of misoprostol treated patients and 23 % of dinoprostoneloxytocin treated patients required Caesarean section. Complications such as uterine tachysy stole were significantly higher in misoprostol group (p < 0.01 ) but it was not associated with increased incidence of uterine hyperstimulatiou. Perinatal outcome was similar in both groups. MJAFI 2001; 57 : 107·109

Termination of Pregnancy in First Trimester - Medical Option

“…It is a known fact that the uterine sensitivity to misoprostol increases with gestational age of fetus. It is also seen in patients with term pregnancy where only 25 gm of the drug induced uterine contractions compared to 800 gm in early pregnancy [8].…”

Influence of nursing interventions in improving midwives´ knowledge of misoprostol use in the management of postpartum haemorrhage at selected hospitals in Ondo State, Nigeria

“…Misoprostol was developed by Searl in 1973 and is a prostaglandin E 1 analogue (cytotec), which can cause powerful contractions of the uterus, even when the uterus is fatigued [ 7 ]. Misoprostol has been recommended as a substitute to oxytocin since it could act as an active uterotonic agent.…”