Induction of long-term receptive field plasticity in the auditory cortex of the waking guinea pig by stimulation of the nucleus basalis.

Bjordahl, Terrence S.; Dimyan, Michael A.; Weinberger, Norman M.

doi:10.1037//0735-7044.112.3.467

Cited by 39 publications

(2 citation statements)

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“…BF cholinergic neurons send dense projections to the auditory cortex (ACx) (Mesulam, Mufson, Wainer, & Levey, 1983), and ACh release is essential for regulating sensory processing and plasticity in ACx (Bakin & Weinberger, 1996; Bjordahl, Dimyan, & Weinberger, 1998; Froemke et al, 2013; Kilgard & Merzenich, 1998; Weinberger, 2007), but the synaptic mechanism underlying the functional plasticity is unknown. To examine how ACh release affects ACx synaptic plasticity in vivo , we combined optogenetics with two-photon microscopy.…”

Section: Resultsmentioning

confidence: 99%

“…Ample evidence from animal studies has showed that BF cholinergic neurons mediate sensory and cognitive functions via ACh release in the neocortex (Bakin & Weinberger, 1996; Bjordahl, Dimyan, & Weinberger, 1998; Bucci, Holland, & Gallagher, 1998; Froemke et al, 2013; Kilgard & Merzenich, 1998; Kim et al, 2016; Lin, Brown, Hussain Shuler, Petersen, & Kepecs, 2015; Meir, Katz, & Lampl, 2018; Parikh et al, 2007; Saper et al, 2010; Teles-Grilo Ruivo et al, 2017; Weinberger, 2007). At the cellular level, ACh has been shown to modulate synaptic plasticity of many types of neurons in vitro (Colangelo et al, 2019; Rasmusson, 2000; Xiang, Huguenard, & Prince, 1998).…”

Section: Discussionmentioning

confidence: 99%

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Acetylcholine release from basal forebrain promotes cortical synaptic plasticity via somatostatin interneurons

Zhao

Zhang

Yang

et al. 2023

Preprint

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The mammalian neocortex receives extensive cholinergic projections from the basal forebrain. Although it has been shown that acetylcholine (Ach) participates in learning-associated cortical plasticity, it's not clear whether Ach can directly modulate structural changes of cortical synapses. Using in vivo two-photon microscopy, we show that optogenetic and chemogenetic stimulation of cholinergic neurons in mouse basal forebrain leads to an increase in spine formation on apical dendrites of layer (L) 5 pyramidal neurons in auditory cortex and posterior parietal cortex, and these newly formed spines follow similar spatial rules as the spontaneously formed new spines. Selective blockage of Ach receptors (AchRs) revealed that nicotinic AchRs, but not muscarinic AchRs, are involved in the stimulation-triggered spine formation. Furthermore, γ-Aminobutyric acid (GABA) transmission is required in this process, indicating that acetylcholine acts through GABAergic connections in promoting spine formation. Together, our findings demonstrate that acetylcholine can induce spine formation in both sensory and higher-order cortices, via activating nicotinic AchRs through GABAergic local circuitry. Our work established a direct link between Ach release and cortical spine formation in vivo, and shed light on synaptic mechanisms underlying Ach-associated cortical remapping and learning-induced plasticity.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Acetylcholine release from basal forebrain promotes cortical synaptic plasticity via somatostatin interneurons

Zhao

Zhang

Yang

et al. 2023

Preprint

View full text Add to dashboard Cite

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The thalamo-cortical auditory receptive fields: regulation by the states of vigilance, learning and the neuromodulatory systems

Edeline

2003

Experimental Brain Research

109

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The goal of this review is twofold. First, it aims to describe the dynamic regulation that constantly shapes the receptive fields (RFs) and maps in the thalamo-cortical sensory systems of undrugged animals. Second, it aims to discuss several important issues that remain unresolved at the intersection between behavioral neurosciences and sensory physiology. A first section presents the RF modulations observed when an undrugged animal spontaneously shifts from waking to slow-wave sleep or to paradoxical sleep (also called REM sleep). A second section shows that, in contrast with the general changes described in the first section, behavioral training can induce selective effects which favor the stimulus that has acquired significance during learning. A third section reviews the effects triggered by two major neuromodulators of the thalamo-cortical system--acetylcholine and noradrenaline--which are traditionally involved both in the switch of vigilance states and in learning experiences. The conclusion argues that because the receptive fields and maps of an awake animal are continuously modulated from minute to minute, learning-induced sensory plasticity can be viewed as a "crystallization" of the receptive fields and maps in one of the multiple possible states. Studying the interplays between neuromodulators can help understanding the neurobiological foundations of this dynamic regulation.

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Cortical network reorganization guided by sensory input features

Kilgard

Pandya

Moucha

2002

Biological Cybernetics

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Sensory experience alters the functional organization of cortical networks. Previous studies using behavioral training motivated by aversive or rewarding stimuli have demonstrated that cortical plasticity is specific to salient inputs in the sensory environment. Sensory experience associated with electrical activation of the basal forebrain (BasF) generates similar input specific plasticity. By directly engaging plasticity mechanisms and avoiding extensive behavioral training, BasF stimulation makes it possible to efficiently explore how specific sensory features contribute to cortical plasticity. This review summarizes our observations that cortical networks employ a variety of strategies to improve the representation of the sensory environment. Different combinations of receptive-field, temporal, and spectrotemporal plasticity were generated in primary auditory cortex neurons depending on the pitch, modulation rate, and order of sounds paired with BasF stimulation. Simple tones led to map expansion, while modulated tones altered the maximum cortical following rate. Exposure to complex acoustic sequences led to the development of combination-sensitive responses. This remodeling of cortical response characteristics may reflect changes in intrinsic cellular mechanisms, synaptic efficacy, and local neuronal connectivity. The intricate relationship between the pattern of sensory activation and cortical plasticity suggests that network-level rules alter the functional organization of the cortex to generate the most behaviorally useful representation of the sensory environment.

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Induction of long-term receptive field plasticity in the auditory cortex of the waking guinea pig by stimulation of the nucleus basalis.

Cited by 39 publications

References 42 publications

Acetylcholine release from basal forebrain promotes cortical synaptic plasticity via somatostatin interneurons

Acetylcholine release from basal forebrain promotes cortical synaptic plasticity via somatostatin interneurons

The thalamo-cortical auditory receptive fields: regulation by the states of vigilance, learning and the neuromodulatory systems

Cortical network reorganization guided by sensory input features

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