Induction of Mania by L-Dopa in a Nonbipolar Patient

Harsch, Harold H.; MILLER, MIKE; Young, Laurens D.

doi:10.1097/00004714-198512000-00006

Cited by 16 publications

(4 citation statements)

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“…Another possible explanation is that enhanced dopaminergic treatment-induced ventral striatal dopamine release due to hypersensetization of the ventral striatal circuitry in a subgroup of PD patients with dopamine dysregulation syndrome has recently been demonstrated by positron emission tomography protocol using (11)C-raclopride binding potential to support a metabolic disturbance at the level of the nucleus accumbens (Evans et al, 2006). A hypomanic state could be another possible explanation, insofar as hypomania has been associated with PD mainly as an 'On' behavioural feature (Harsch et al, 1985;Cummings, 1991). This study has several limitations, notably that there is no validated tool to quantify the behavioural features we assessed in our PD population.…”

Section: Discussionmentioning

confidence: 99%

New onset heightened interest or drive for gambling, shopping, eating or sexual activity in patients with Parkinson's disease: the role of dopamine agonist treatment and age at motor symptoms onset

et al. 2007

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Alterations of impulse control that have recently been associated with Parkinson's disease (PD) are serious behavioural disturbances with significant impact on PD patients and their families.A total of 193 consecutive PD patients with no history of psychiatric illness and 190 age/gender-matched healthy controls were queried on the presence of new onset heightened interest or drive for gambling, shopping, eating or sexual activity (GSES). Clinical data were retrieved from medical charts and interviews. logistic regressions models assessed risk factors for these specific troublesome behaviours. New or heightened interests or drives for GSES behaviours were reported by 27 patients (14% vs 0% for controls). Younger age at PD motor symptoms onset (OR = 0.99, p = 0.0172), male gender (OR = 1.10, p = 0.0576) and longer duration of treatment with dopamine agonists (DAs)(OR = 1.18, >/=6 years versus never treated, p = 0.0459) contributed additively to the risk of developing one or more of these behavioural features. New onset heightened interests or drives for GSES are not rare behavioural disturbances among patients with PD. Age, gender and duration of treatment with DAs have an independent and additive effect on the risk to develop such behavioural changes. Patients should be informed about potential treatment-associated behavioural changes.

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Section: Discussionmentioning

confidence: 99%

New onset heightened interest or drive for gambling, shopping, eating or sexual activity in patients with Parkinson's disease: the role of dopamine agonist treatment and age at motor symptoms onset

et al. 2007

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“…Bipolar affective disorder has an approximate lifetime prevalence of 1%, and about half of the patients develop psychosis, predominantly in the manic phase . Psychotic symptoms in bipolar affective disorder respond to antipsychotic drugs (dopamine D 2 /D 3 blockers), suggesting that a dopaminergic abnormality could underlie these symptoms . Dopamine synthesis capacity is unaltered in bipolar disorder without psychosis, although it remains unclear if dopamine synthesis capacity is altered in individuals with bipolar disorder with a history of psychosis, whether this is related to psychotic symptoms, or how this compares with schizophrenia.…”

Section: Introductionmentioning

confidence: 99%

A Test of the Transdiagnostic Dopamine Hypothesis of Psychosis Using Positron Emission Tomographic Imaging in Bipolar Affective Disorder and Schizophrenia

et al. 2017

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“…Of note, a very recent study found that 11.1% and 5.6% of patients with PD in treatment with dopamine agonists developed, respectively, a hypomanic and a manic episode. [114][115] Apart from L-dopa, droxidopa, and selegiline induced mania, [116][117][118] induction of mania by apomorphine in a depressed patient with PD has been described. 119 Dopaminergic agents can also reexacerbate manic symptoms in patients with a history of bipolar disorder.…”

Section: Treatmentmentioning

confidence: 99%

Psychiatric Conditions in Parkinson Disease

Buoli

Caldiroli

Altamura

2015

J Geriatr Psychiatry Neurol

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Psychiatric conditions often complicate the outcome of patients affected by Parkinson disease (PD), but they differ from classical psychiatric disorders in terms of underlying biological mechanisms, clinical presentation, and treatment response. The purpose of the present review is to illustrate the biological and clinical aspects of psychiatric conditions associated with PD, with particular reference to the differences with respect to classical psychiatric disorders. A careful search of articles on main databases was performed in order to obtain a comprehensive review about the main psychiatric conditions associated with PD. A manual selection of the articles was then performed in order to consider only those articles that concerned with the topic of the review. Psychiatric conditions in patients with PD present substantial differences with respect to classical psychiatric disorders. Their clinical presentation does not align with the symptom profiles represented by Diagnostic and Statistical Manual for Mental Disorders and International Classification of Diseases. Furthermore, psychiatry treatment guidelines are of poor help in managing psychiatric symptoms of patients with PD. Specific diagnostic tools and treatment guidelines are needed to allow early diagnosis and adequate treatment of psychiatric conditions in comorbidity with PD.

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Induction of Mania by L-Dopa in a Nonbipolar Patient

Cited by 16 publications

References 0 publications

New onset heightened interest or drive for gambling, shopping, eating or sexual activity in patients with Parkinson's disease: the role of dopamine agonist treatment and age at motor symptoms onset

New onset heightened interest or drive for gambling, shopping, eating or sexual activity in patients with Parkinson's disease: the role of dopamine agonist treatment and age at motor symptoms onset

A Test of the Transdiagnostic Dopamine Hypothesis of Psychosis Using Positron Emission Tomographic Imaging in Bipolar Affective Disorder and Schizophrenia

Psychiatric Conditions in Parkinson Disease

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