Induction of necrosis and failure in the isolated perfused rat heart with oxidized isoproterenol

Semiquinone Anion Radicals of Catechol(amine)s, Catechol Estrogens, and Their Metal Ion Complexes

“…and catecholamines (i.e., dopa methyl ester, dopamine, 3,4-dihydroxybenzylamine, and 5-S-cysteinyldopa) in both in vitro and in vivo systems has been reported (4)(5)(6)(7)(8)(9). Side effects have been reported for all these drugs, and include hepatic injury (10), cardiotoxicity (11), hemolysis (12) and photosensitivity (13). These side effects and the cytotoxicity of these drugs in general are thought to be related to the production of damaging free radicals and o-quinones (14)(15)(16)(17)(18)(19)(20).…”

An Evaluation of Antioxidant Potential of Flavonoid Eriodictyol in Isoproterenol-Induced Myocardial Infarction in Rats

“…Cell injury induced by free radical particularly reactive oxygen species is an important mechanism of cell damage in pathologic conditions, ischemia and in cellular ageing. 33 Catecholamines are also known to cause increased reactive oxygen species generation through oxidation and subsequent oxidative stress 34 which leads to myocardial necrosis. 35,36 The formation of free radicals and the accumulation of lipid peroxides is one of the most major biochemical changes associated with myocardial damage induced by catecholamines.…”

Vasopressors for cardiopulmonary resuscitation

“…The oxidation products of catecholamines have been known for some time to cause damage to myocardial tissue (Yates and Dhalla 1975;Dhalla et al 1978) although it is not known if they are more or less harmful than adrenaline itself (Bindoli et al 1992;Behonick et al 2001). It has been demonstrated that oxidation of catecholamines is partially responsible for the increased levels of free radicals observed during ischaemia.…”