Induction of necrosis factor-α and interleukin-6 in mice in vivo and in murine peritoneal macrophages and human whole blood cells in vitro by Micrococcus luteus teichuronic acids

Monodane, Toshihiko; Kawabata, Yoshihiro; Yang, Shiliang; Hase, Sumihiro; Takada, Haruhiko

doi:10.1099/0022-1317-50-1-4

Cited by 10 publications

(7 citation statements)

References 20 publications

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“…Unlike the usual peptidoglycans from various gram-positive bacteria, those from M. luteus lacked immunomodulating activities such as immunoadjuvant activity (19), antitumor activity (11), mitogenic activity (12), and cytokine-inducing activity (21). We showed that the cytokine-inducing activity of M. luteus cell walls was attributable to the TUA portion and not to the peptidoglycan portion (25). Furthermore, the activity of TUA was detected in an in vivo experiment using C3H/HeN mice and in peritoneal macrophage cultures from C3H/HeN mice but not from C3H/HeJ mice (25).…”

mentioning

confidence: 79%

“…We showed that the cytokine-inducing activity of M. luteus cell walls was attributable to the TUA portion and not to the peptidoglycan portion (25). Furthermore, the activity of TUA was detected in an in vivo experiment using C3H/HeN mice and in peritoneal macrophage cultures from C3H/HeN mice but not from C3H/HeJ mice (25).…”

mentioning

confidence: 79%

“…This is the first report of a TLR4-recognized chemically defined cell surface component prepared from gram-positive bacteria. Furthermore, immunobiological activities of this bacterium are attributable mainly to TUA (25), because peptidoglycans of this bacterium lacked bioactivities, as described above. Thus, it is possible that whole cells of this gram-positive bacterium might be recognized by TLR4, not by TLR2, unlike the case for most gram-positive bacteria.…”

Section: Discussionmentioning

confidence: 99%

“…1. The possible contaminating LPS contents in p-TUA and p-TUA-[H] were calculated as 0.091 and 0.070 ng/mg, respectively, based on the results of the colorimetric Limulus test using Escherichia coli O111:B4 LPS as a control (25). Ultrapurified LPS prepared from Salmonella choleraesuis subsp.…”

Section: Methodsmentioning

confidence: 99%

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Micrococcus luteusTeichuronic Acids Activate Human and Murine Monocytic Cells in a CD14- and Toll-Like Receptor 4-Dependent Manner

et al. 2001

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confidence: 79%

mentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Micrococcus luteusTeichuronic Acids Activate Human and Murine Monocytic Cells in a CD14- and Toll-Like Receptor 4-Dependent Manner

et al. 2001

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“…Furthermore, they showed a priming effect of MDP on LPS-induced cytokine gene expression in mouse bone marrow-derived macrophages in culture [42]. In MDPprimed mice, the enhanced production of inflammatory cytokines such as interleukin (IL)-1, IL-6 and TNF-α was induced upon stimulation with various bacterial components as well as LPS; lipoteichoic acid (TUA) from Micrococcus luteus [43], whole cells and extracellular products of oral streptococci [44], mycobacterial lipoarabinomannan (LAM) and lipopeptides from mycoplasma and other bacteria (unpublished). TUA was a TLR4 agonist [45] while lipopeptides and LAM were TLR2 agonists [46][47][48].…”

Section: Enhancement Of Endotoxin Activity In Mdp-primed Micementioning

confidence: 99%

Enhancement of TLR-Mediated Innate Immune Responses by Peptidoglycans through NOD Signaling

Takada

Uehara

2006

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Toll-like receptors (TLRs) recognize common motifs, pathogen-associated molecular patterns (PAMPs), in microorganisms. Bacterial PAMPs are mainly distributed on cell-surfaces. Peptidoglycans (PGNs) are ubiquitous constituents of bacterial cell walls. Muramyldipeptide (MDP; N-acetylmuramyl-l-alanyl-d-isoglutamine) is a common and key structure of PGNs and exhibits most the of bioactivities of PGNs. Recently, the intracellular receptor for MDP was revealed to be NOD2. Another bioactive moiety of PGNs, diaminopimelic acid (DAP) containing desmuramylpeptides (DMPs), senses another intracellular receptor, NOD1. MDP-primed mice exhibited hyper-responses to endotoxin and other bacterial components, which sense Toll-like receptors (TLRs), although MDP itself does not exhibit apparent activity in mice. On the other hand, DMPs exhibited definite activity in mice, and the most powerful DMP, FK565, exhibited stronger priming activity than MDP. In human monocytic cells, both MDP and DMPs exhibited definite activities; marked synergistic interleukin (IL)-8 secretion was induced by DMPs and MDP in combination with synthetic TLR agonists, and suppression of the mRNA expressions of NOD1 and NOD2, respectively, by RNA interference specifically inhibited synergistic IL-8 secretion. In human dendritic cells (DCs), synergistic T helper type 1 responses are induced by combined stimulations of synthetic NOD and TLR agonists. Considering these findings altogether, in host-bacteria interactions, host cells should recognize bacteria via both TLRs and NODs, which might induce synergistic innate and adaptive immune responses.

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Teichoic and Teichuronic Acids from Gram‐Positive Bacteria

et al. 2002

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Introduction Historical Outline Chemical Structures Cell Wall Teichoic Acid Teichuronic Acids Biosynthesis and Genetics of Poly(GroP) Polymerizing Enzyme System for Poly(Glycerol Phosphate) Teichoic Acid The Genetic Basis of the Biosynthesis of the Soluble Precursors Transcriptional Regulation of Wall Teichoic Acid Genes in B. subtilis 168 Biosynthesis and Genetics of Poly (3‐ O ‐β‐D‐Glucopyranosyl N‐Acetylgalactosamine 1‐Phosphate) Genetic and Biochemical Analysis of Mutants Genes Involved in Synthesis of Soluble Precursors UDPGalNAc Genetics of Polymerizing Enzyme System Biosynthesis and Genetics of the B. subtilis 168 Cell Wall Teichuronic Acids Biodegradation Biological Roles Associated with Cell Wall Teichoic and Teichuronic Acids Horizontal Transfer of Genes for Wall Teichoic Acid Synthesis Role of the D‐Alanine Substituent of Wall Teichoic Acid and of the Overall Cell Wall Negative Charge The pH Gradient Across the Cell Wall Cell Wall Teichoic Acid and Upkeep of the Cell Shape Applications

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Induction of necrosis factor-α and interleukin-6 in mice in vivo and in murine peritoneal macrophages and human whole blood cells in vitro by Micrococcus luteus teichuronic acids

Cited by 10 publications

References 20 publications

Micrococcus luteusTeichuronic Acids Activate Human and Murine Monocytic Cells in a CD14- and Toll-Like Receptor 4-Dependent Manner

Micrococcus luteusTeichuronic Acids Activate Human and Murine Monocytic Cells in a CD14- and Toll-Like Receptor 4-Dependent Manner

Enhancement of TLR-Mediated Innate Immune Responses by Peptidoglycans through NOD Signaling

Teichoic and Teichuronic Acids from Gram‐Positive Bacteria

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