Induction of oral tolerance and the effect of interleukin-4 on murine skin allograft rejection

Dettino, A. L. A.; Duarte, Alberto José da Silva; Sato, Maria Notomi

doi:10.1590/s0100-879x2004000300022

Cited by 8 publications

(4 citation statements)

References 21 publications

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“…This result suggests that mucosal p277 peptide therapy can modify the dynamics of skin graft rejection in our models. Similar to our results, the use of different tolerization schedules with other antigens (donor cells, cytokines) employed in skin transplantation models has slightly increased the graft survival time (2–6 days over the control groups) [24, 25].…”

Section: Discussionsupporting

confidence: 85%

Treatment with Encapsulated Hsp60 Peptide (p277) Prolongs Skin Graft Survival in a Murine Model of Minor Antigen Disparity

et al. 2007

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The increased expression of heat shock protein (Hsp)60 in different kinds of graft tissues has been associated with a proinflammatory role and rejection. However, there are very few reports in which treatment with Hsp60 delays skin allograft rejection. The aim of this work was to evaluate the capacity of encapsulated human Hsp60‐derived peptide p277 to delay graft rejection in two murine models of skin transplantation with minor antigen disparities. Briefly, BALB/c mice and C57BL/6 were intranasally pre‐treated with five doses of Hsp60 p277 peptide encapsulated in polylactide‐co‐glycolide acid microspheres (PLGM), and received skin grafts from DBA2 mice and 129/B6 (F1) mice respectively. The treatment with the peptide increased skin graft survival more than 20 days in both the mouse strains, mainly in C57BL/6 recipients (P < 0.05). Also, p277‐treated BALB/c and C57BL/6 mice showed IL‐10 and IFN‐γ production, induced by p277 peptide. For the first time, a mucosal schedule using the Hsp60 C‐terminal peptide p277 encapsulated in PLGM showed some survival prolongation of skin grafts bearing minor antigen disparities. Our results suggest a potential role for Hsp60‐based therapy and the mucosal route as a useful tool to control the inflammatory response to allografts.

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Section: Discussionsupporting

confidence: 85%

Treatment with Encapsulated Hsp60 Peptide (p277) Prolongs Skin Graft Survival in a Murine Model of Minor Antigen Disparity

et al. 2007

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“…Some experimental transplantation studies 20,21 have described oral administration of spleen cells along with the transplanted tissue in order to reduce the rejection, as well as the amount of immunosuppressive agents being used. This makes it possible to justify the evolution of better lipid profile in Group 4.…”

Section: Results Results Results Resultsmentioning

confidence: 99%

Effects of splenic allograft in lipid profile of non-splenectomized rats: the immune and metabolic role of the "double spleen"

Gonçalves

Yamaki

Feijó

et al. 2014

Rev. Col. Bras. Cir.

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Gonçalves Gonçalves Gonçalves Gonçalves GonçalvesEffects of splenic allograft in lipid profile of non-splenectomized rats: the immune and metabolic role of the "double spleen"Original Article Original Article Original Article Original Article Original Article Effects of splenic allograft in lipid profile of non-splenectomized Effects of splenic allograft in lipid profile of non-splenectomized Effects of splenic allograft in lipid profile of non-splenectomized Effects of splenic allograft in lipid profile of non-splenectomized Effects of splenic allograft in lipid profile of non-splenectomized rats: the immune and metabolic role of the "double spleen" rats: the immune and metabolic role of the "double spleen" rats: the immune and metabolic role of the "double spleen" rats: the immune and metabolic role of the "double spleen" rats: the immune and metabolic role of the "double spleen"Efeitos do aloenxerto esplênico no lipidograma de ratos não esplenectomizados: Efeitos do aloenxerto esplênico no lipidograma de ratos não esplenectomizados: Efeitos do aloenxerto esplênico no lipidograma de ratos não esplenectomizados: Efeitos do aloenxerto esplênico no lipidograma de ratos não esplenectomizados: Efeitos do aloenxerto esplênico no lipidograma de ratos não esplenectomizados: papel imunológico e metabólico do "baço duplo" papel imunológico e metabólico do "baço duplo" papel imunológico e metabólico do "baço duplo" papel imunológico e metabólico do "baço duplo" papel imunológico e metabólico do "baço duplo" (1), total splenectomy group (2), splenectomy and implantation of allograft group (3) and double spleen group (4). Each group was subdivided into two subgroups: A and B, based on the death of the animals after 30 or 120 days of monitoring. The procedures in groups 2, 3 and 4 were made simultaneously, and splenectomized animals, groups 2 and 3 were donors, respectively, for the animals of groups 3 and 4. In group 4 the spleen was preserved and the animals received implants from the spleens of rats from group 3. The regeneration of splenic tissue was evaluated by macroscopic and microscopic analyzes of the grafts and own spleens, as well as with measurements of VLDL, HDL, LDL, total cholesterol and triglycerides. Results Results ResultsResults Results: after 120 days, Group 4 showed levels of total cholesterol and LDL lower than the other groups. Group 1 had higher levels of lipids. Conclusion Conclusion Conclusion Conclusion Conclusion: The technique of double spleen was effective in the control of lipid metabolism, corroborating the function of the spleen as a reserve of lipids.

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“…More recently, Wilkes' group reported that tolerance against fully-mismatched lung allografts could be achieved using a self-protein, collagen type V (col-V) (114). Administration of donor antigens has also been found to be effective using intragastric (115), intra-jejunal (116), transrectal, and intratracheal routes (107). The tolerance induced using such transmucosal routes has been shown to be T cell dependant as T cells, but not serum, from tolerized recipients could transfer tolerance.…”

Section: Extra-thymic Inoculation Of Allopeptidesmentioning

confidence: 99%

Allopeptides and the alloimmune response

Bharat

Mohanakumar

2007

Cellular Immunology

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The inherent ability of the host immune system to distinguish between self- and non-self forms the basis of allorecognition. T lymphocytes constitute the most important effector arm of allorecognition. Here we describe the fundamentals of direct and indirect pathways by which allopeptides are presented to effector T cells. The nature of allopeptides presented along with tolerogenic strategies like altered peptide ligands and intra- or extra-thymic allopeptide inoculation are discussed. In addition, we speculate on the potential of regulatory T cells to modulate alloimmune responses.

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Induction of oral tolerance and the effect of interleukin-4 on murine skin allograft rejection

Abstract: We studied the effect of oral and portal vein administration of alloantigens on mouse skin allograft survival.

Cited by 8 publications

References 21 publications

Treatment with Encapsulated Hsp60 Peptide (p277) Prolongs Skin Graft Survival in a Murine Model of Minor Antigen Disparity

Treatment with Encapsulated Hsp60 Peptide (p277) Prolongs Skin Graft Survival in a Murine Model of Minor Antigen Disparity

Effects of splenic allograft in lipid profile of non-splenectomized rats: the immune and metabolic role of the "double spleen"

Allopeptides and the alloimmune response

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