Induction of ovulation in seasonally anestrous mares under ambient lights using recombinant equine FSH (reFSH)

Meyers-Brown, Geraldine; McCue, Patrick M.; Troedsson, Mats H.T.; Klein, Claudia; Zent, Walter W.; Ferris, Ryan A.; Lindholm, Alicia R.G.; Scofield, D.B.; Claes, A.; Morganti, M.; Colgin, M.; Wetzel, Robert L.; Peters, A. R.; Roser, Janet F.

doi:10.1016/j.theriogenology.2013.04.029

Cited by 14 publications

(8 citation statements)

References 18 publications

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“…Vários estudos vêm sendo realizados visando o aumento da eficiência reprodutiva das éguas, alguns deles com o uso de fármacos (Thompson e Witherspoon, 1974;Alcântara et al, 2005;Meyers-Brown et al, 2013) e de biotecnologias avançadas da reprodução equina (Coutinho da Silva et al, 2004;Meyers-Brown et al, 2011;Nagao et al, 2012 …”

Section: Introductionunclassified

Condição corporal e atividade reprodutiva de eguas

et al. 2014

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A manutenção dos animais em boa condição corporal é de grande importância para se alcançar altos índices reprodutivos, tanto à monta natural quanto frente às modernas biotecnologias da reprodução equina. A presente revisão de literatura teve como objetivo abordar a influência da condição corporal sobre a atividade reprodutiva de éguas, enfocando a atividade ovariana, o perfil endócrino, sendo dada ênfase à leptina, pois seus níveis estão diretamente relacionados à condição corporal e envolvidos no estímulo do eixo hipotálamo-hipófise-gônadas, e os índices de eficiência reprodutiva. Considerando uma escala de escore da condição corporal (1 a 9), éguas com escore > 5 são consideradas aptas a apresentarem índices de eficiência reprodutiva satisfatórios. Em síntese, a condição corporal exerce efeito sobre: a duração do anestro estacional e do período interovulatório, a secreção de IGF-1 e leptina, o número de ciclos/concepção, as taxas de prenhez, perda embrionária precoce e aborto. SUMMARYKeeping animals in good body condition is of great importance to achieve high reproductive rates, both the natural mating as the face of modern biotechnologies equine reproduction. This literature review aimed to evaluate the influence of body condition on reproductive activity in mares, focusing on ovarian activity, the endocrine profile, with an emphasis on leptin, because their levels are directly related to body condition and involved in stimulating hypothalamic-pituitary -gonadal axis, and the indices of reproductive efficiency.Considering a range of body condition score (1-9), mares with scores >5 are considered able to submit satisfactory levels of reproductive efficiency. Additionally, the body condition has an effect on the duration of seasonal anestrus, the interovulatory period, the secretion of IGF-1 and leptin, the number of cycles/conception, the pregnancy rates, early embryonic loss and abortion. INTRODUÇÃOEm um programa reprodutivo de equinos espera-se o nascimento de um potro saudável por égua, dentro do intervalo de um ano. Para isso, é necessário que se tenha éguas e garanhões de boa fertilidade, além de manejos reprodutivo, nutricional e sanitário adequados.Para a avaliação da fertilidade são adotados índices de eficiência reprodutiva, que refletem a fertilidade tanto individual como do plantel. Vários estudos vêm sendo realizados visando o aumento da eficiência reprodutiva das éguas, alguns deles com o uso de fármacos (Thompson e Witherspoon, 1974;Alcântara et al., 2005;Meyers-Brown et al., 2013) e de biotecnologias avançadas da reprodução equina (Coutinho da Silva et al., 2004;Meyers-Brown et al., 2011;Nagao et al., 2012

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Section: Introductionunclassified

Condição corporal e atividade reprodutiva de eguas

et al. 2014

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“…In present study, Estrus response was 83.3% and 28.6% in group A, B, respectively and showed significant (P<0.05) relation with each other and with control group mares. Meyers-Brown et al (2013) said that mares in treatment group had developed ≥35mm follicle within 7.4±1.6-days of recombinant follicle stimulating hormone treatment, mares of control group (kept untreated) exhibit no significant development of follicles. It has been reported earlier that a single injection of 40 µg buserelin when follicles are at least 45mm in diameter and uterine edema is decreased is effective for inducing ovulation (Miki et al 2016).…”

Section: Discussionmentioning

confidence: 99%

Effect of Tocopherol and Selenium on the Performance of Buserelin for Estrus Induction in Late Season Anestrus Mares (Equus Caballus)

et al. 2021

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The aim of this study was to determine the effect of tocopherol and selenium on the performance of buserelin (GnRH analogue) for estrus induction in anestrus mares. A total of 18 seasonally anestrus mares were divided into three equal groups (n=6 in each) after ovarian scanning. Mares in group A (treatment group) were treated with tocopherol and selenium intramuscularly along with daily dose of buserelin. Mares which came into heat within ten-day buserelin protocol, further injections of buserelin for those mares were stopped. Mares in group B were treated with buserelin intramuscularly only for ten days. Mares which came into heat within ten-day buserelin protocol, further injections of buserelin were stopped. Blood/serum was collected from each experimental mare kept in different groups (A-C) at days 1, 11, 12, 13 and 14. Onset of estrus signs was 83.3, 33.3 and 0% in group A, B and C, respectively, that was significant (P<0.05) among groups. Follicular dynamics were 20.24±3.00, 14.59±2.24 and 10.35±0.63mm in groups A, B and C, respectively with significant (P˂0.05) difference. Change in serum E2 contents was significantly (P˂0.05) different among groups A, B and C whereas progesterone concentration showed non-significant difference among groups.

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“…The use of recombinant equine FSH (reFSH) has been reported to induce follicular growth in cyclic mares [58,59]. A study reviewed in 2013 however determined the efficacy of it in deep anestrous mares to be very successful with ovulation rate of 76.7% in response to FSH treatment followed by human chorionic gonadotropin (hCG) administration [60].…”

Section: Recombinant Equine Fsh (Refsh) and Lh (Relh)mentioning

confidence: 99%

Physiological and Clinical Aspects of the Endocrinology of the Estrous Cycle and Pregnancy in Mares

Satué¹,

Gardón²

2021

Animal Reproduction in Veterinary Medicine

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The use of advanced reproductive endocrinology can generate important economic benefits for equine breeding farms. Pregnancy in the mare involves considerable endocrine changes, which can be explained in part by the development of different structures such as embryonic vesicles, primary and secondary CL, endometrial cups and development of fetoplacental units. Both the pregnant mare and the fetus adapt to this development with unique mechanisms, such as alterations in the maternal endocrine metabolism and hormonal feedback. Since the ability to produce a viable foal is critical for the broodmare, the maintenance of the gestation implies almost a year of physiological effort. Therefore, the joint knowledge of basic reproductive science and current clinical endocrinology allows veterinarians and breeders to be better positioned to achieve their objectives. This chapter reviews normal and abnormal endocrine patterns during the equine estrual cycle, pregnancy. We also consider hormonal evaluation related to placentitis, abortions, recurrent pregnancy loss, and premature deliveries. Also, several aspects associated with endocrinological control of the reproductive cycle, ovulation, parturition, high-risk mare, and hormone supplementation will be developed.

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Induction of ovulation in seasonally anestrous mares under ambient lights using recombinant equine FSH (reFSH)

Cited by 14 publications

References 18 publications

Condição corporal e atividade reprodutiva de eguas

Condição corporal e atividade reprodutiva de eguas

Effect of Tocopherol and Selenium on the Performance of Buserelin for Estrus Induction in Late Season Anestrus Mares (Equus Caballus)

Physiological and Clinical Aspects of the Endocrinology of the Estrous Cycle and Pregnancy in Mares

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