Induction of ovulation with purified urinary follicle-stimulating hormone in patients with polycystic ovarian syndrome

Garcea, N; Campo, Sebastiano; Panetta, V.; Venneri, Maria; Siccardi, P.; Dargenio, Ruggero; Tomasi, Franco

doi:10.1016/0002-9378(85)90154-1

Cited by 59 publications

(19 citation statements)

References 9 publications

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“…The use of gonadotropins for inducing follicle maturation increased the incidence of OHSS as well as producing a higher rate of ovulation. The daily injection of hMG or purified FSH has been used to induce ovulation in PCOS patients, with varying success rates and a high incidence of serious side effects associ ated with hyperstimulation [3][4][5]. Although the pulsatile administration of hMG slightly reduced the incidence of OHSS compared with the daily injection of hMG, this difference was not significant.…”

Section: Resultsmentioning

confidence: 87%

A Study on Follicle Stimulation and Ovulation Induction in Polycystic Ovary Syndrome (PCOS)

Ito

Michioka²,

Kobayashi³

et al. 1990

Horm Res

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The present study was undertaken to verify the efficacy of preparations for inducing follicular maturation and ovulation in patients with polycystic ovary syndrome (PCOS). Successful induction of ovulation in patients with PCOS was observed in treatment cycles with daily injections or pulsatile subcutaneous administration of human menopausal gonadotropin (hMG), the combination of clomiphene citrate and bromocriptine, or the combination of clomiphene citrate and hMG. The incidence of ovarian hyperstimulation syndrome varied with the different clinical conditions in which ovulation was induced, the types of preparations administered, and the doses and schedules administered.

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Section: Resultsmentioning

confidence: 87%

A Study on Follicle Stimulation and Ovulation Induction in Polycystic Ovary Syndrome (PCOS)

Ito

Michioka²,

Kobayashi³

et al. 1990

Horm Res

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“…The high levels of endogenous LH in patients with PCOS increase the risk of hyperstimulation associated with the use of gonadotropins that are currently available [1,4]. The use of FSH alone for follicular maturation prior to induction of ovulation with exogenous hCG was noted to be associated with a lower incidence of hyper stimulation than when hMG was used [5,14], In five patients with PCOS who received both the hMG (group I) and FSH regimens (group III), there was no signifi cant difference in the incidence of hyperstimulation be tween the two treatments. The present data do not sup port the suggestion of Kamrava et al [14] that reducing exogenous LH to a minimum might eliminate the risk of hyperstimulation, especially in patients with PCOS.…”

Section: Discussionmentioning

confidence: 99%

“…Successful induction of ovulation with purified prep arations of FSH in patients with PCOS has been re ported in numerous publications [5,14], Berger et al…”

Section: Discussionmentioning

confidence: 99%

“…Gonadotropins administration and bilat eral wedge resection therapies have also been shown to have significant advantages for inducing ovulation in CC-unresponsive patients [3][4][5]9]. The conventional daily intramuscular administration of hMG is always associated with the haunting spectre of hyperstimulation and severe multiple pregnancies or failure to obtain ovu lation at all [1,4,11,12], The response to ovarian wedge resection is variable, and most patients return to their anovulatory state in a few years [9], Furthermore, the surgical procedure is associated with the potential prob lem of postoperative adhesion formation.…”

Section: Discussionmentioning

confidence: 99%

“…Polycystic ovary syndrome (PCOS) is one of the ma jor causes of infertility and subfertility in women [1,2], The daily injection of human menopausal gonadotro pin (hMG) or purified follicle-stimulating hormone (FSH) has been used to induce ovulation in PCOS patients, with varying success rates and a high inci dence of serious side effects associated with hypersti mulation [3][4][5], Recent studies have demonstrated that pulsatile administration of hMG intravenously or sub cutaneously may have the advantage of replicating nor mal gonadotropin function in patients with various types of anovulatory infertility [6,7], This approach is capable of inducing the absorption dynamics of gonad otropins, resembling the periodic release at a frequency of 1-2 h by the pituitary gland [7,8]. The previous data revealed that pulsatile subcutaneous administration of hMG or FSH was effective in the induction of success ful ovulation and the establishment of singleton preg nancy in patients with various types of anovulatory infertility.…”

Section: Introductionmentioning

confidence: 99%

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Induction of Ovulation with Pulsatile Subcutaneous Administration of Human Menopausal Gonadotropin in Patients with Polycystic Ovary Syndrome

et al. 1990

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The present study was undertaken to determine whether ovulation can be induced in patients with polycystic ovary syndrome (PCOS) by pulsatile subcutaneous administration of hMG after the pituitary secretion of LH and FSH was suppressed with a gonadotropin releasing hormone (GnRH) analogue. The results of the combined regimen cycles (group II) were compared with those of hMG (group I) or FSH (group III) pulsatile administration in the same PCOS patients. The ovulation rate (89.1 % of 46 cycles) in group I was significantly greater (p < 0.01) than that found in group II (65.9% of 41 cycles). In group III, ovulation occurred in 89.5% of the 19 treatment cycles. Ovarian hyperstimulation syndrome (OHSS) occurred in 28.3% of cycles in group I, 7.3% in group II, and 26.3% in group III, respectively. The incidence of OHSS in group II was significantly lower than that found in group I or III. The rates of pregnancy were 10.9 % of cycles in group I, 4.9 % in group II, and 21.1 % in group III, respectively. All 10 fetuses were singleton conceptions, and the pregnancies continued successfully to term. The present data demonstrate that pulsatile subcutaneous administration of hMG or FSH is effective in the induction of successful ovulation and the establishment of singleton pregnancy in patients with PCOS.

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Pulsatile luteinising hormone releasing hormone for ovulation induction in subfertility associated with polycystic ovary syndrome

Bayram

Wely

Vandekerckhove

et al. 1999

Cochrane Database of Systematic Reviews

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Induction of ovulation with purified urinary follicle-stimulating hormone in patients with polycystic ovarian syndrome

Cited by 59 publications

References 9 publications

A Study on Follicle Stimulation and Ovulation Induction in Polycystic Ovary Syndrome (PCOS)

A Study on Follicle Stimulation and Ovulation Induction in Polycystic Ovary Syndrome (PCOS)

Induction of Ovulation with Pulsatile Subcutaneous Administration of Human Menopausal Gonadotropin in Patients with Polycystic Ovary Syndrome

Pulsatile luteinising hormone releasing hormone for ovulation induction in subfertility associated with polycystic ovary syndrome

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