Induction of oxidative DNA damage and early lesions in rat gastro-intestinal epithelium in relation to prostaglandin H synthase-mediated metabolism of butylated hydroxyanisole

Schilderman, P.A.E.L.; Vaarwerk, F.J.ten; Lutgerink, Jan T.; Wurff, A. Van Der; Hoor, F. ten; Kleinjans, Jos

doi:10.1016/0278-6915(94)00125-8

Cited by 48 publications

(25 citation statements)

References 34 publications

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“…All active microalgal species showed a antioxidant activity lower (P<0.05) than the synthetic antioxidant BHT. However, antioxidants such as BHT and butylated hydroxyanisole (BHA) are questionable in terms of their safe use, since they are believed to be carcinogenic and tumorigenic if given in high doses (Bran 1975;Whysner et al 1994;Aruoma 2003); e.g., BHA has been shown by Schildermann et al (1995) to induce cancer in the rat fore stomach. Regardless of the risks due to high levels of toxicity, BHA and BHT are still being used in the food industry due to their high antioxidant properties (Papas 1999).…”

Section: Discussionmentioning

confidence: 99%

Screening of Malaysian indigenous microalgae for antioxidant properties and nutritional value

et al. 2007

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Fourteen indigenous microalgal samples from Malaysia were isolated, purified and cultured from fresh, brackish and marine waters. The ability of the microalgae to be natural sources of antioxidants was studied by a screening test using three antioxidant chemical assays [ferric thiocyanate (FTC), thiobarbituric acid (TBA) and 1, 1'-diphenyl-2-picrylhydrazyl (DPPH)]. The results showed that six microalgal methanolic crude extracts (Isochrysis galbana, Chaetoceros calcitrans, Scenedesmus quadricauda, Chlorella vulgaris, Nannochloropsis oculata and Tetraselmis tetrathele) were active in inhibiting the lipid peroxidation of linoleic acid. Among all the microalgae, I. galbana and C. calcitrans showed the highest antioxidant activity (>90%) in FTC and TBA assays, indicating that these microalgae might contain active compounds for protection from lipid peroxidation. Nutritional analyses were performed on microalgae with high antioxidant activities (I. galbana and C. calcitrans) in order to investigate their nutritive value. Both microalgae were found to be rich in nutrients. For examples, I. galbana had average percentage composition of protein, carbohydrate, and lipid, as 47.9±2.5; 26.8±0.2; 14.5±1.4%, respectively, while the corresponding values for C. calcitrans were 36.4±

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Section: Discussionmentioning

confidence: 99%

Screening of Malaysian indigenous microalgae for antioxidant properties and nutritional value

et al. 2007

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“…In the last years the interest of natural antioxidant such as those present in spices, has increased because of the increasing restrictions in the use of the synthetic antioxidans in foods (38,40,41).…”

Section: Biological Activities Of Rosmarinic Acid Antioxidant Activitymentioning

confidence: 99%

Basil: A Source of Rosmarinic Acid

Juliani

Koroch

Simon

2008

ACS Symposium Series

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“…However, they display toxicity by inducing DNA damage (Ito, Fukushima, Tamano, Hirose, & Hagiwara, 1986;Schilderman et al, 1995). Their replacement by phenolic antioxidants (flavonoids, phenolic acids) from natural sources (plant antioxidants listed by Halliwell, Aeschbach, Löliger, & Aruoma, 1995) has been extensively investigated (e.g., Rice-Evans, Miller, & Paganda, 1996).…”

Section: Introductionmentioning

confidence: 97%

Isolation and identification of antioxidative peptides from bovine α-lactalbumin

Sadat

Cakir-Kiefer

N’Negue

et al. 2011

International Dairy Journal

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Induction of oxidative DNA damage and early lesions in rat gastro-intestinal epithelium in relation to prostaglandin H synthase-mediated metabolism of butylated hydroxyanisole

Cited by 48 publications

References 34 publications

Screening of Malaysian indigenous microalgae for antioxidant properties and nutritional value

Screening of Malaysian indigenous microalgae for antioxidant properties and nutritional value

Basil: A Source of Rosmarinic Acid

Isolation and identification of antioxidative peptides from bovine α-lactalbumin

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