Induction of oxidative stress and the transcription of genes related to apoptosis in rare minnow (Gobiocypris rarus) larvae with Aroclor 1254 exposure

Developmental retardation, reduced fecundity, and modulated expression of the defensome in the intertidal copepod Tigriopus japonicus exposed to BDE-47 and PFOS

“…In T. japonicus, the Tjp53 transcript was upregulated in response to BDE-47 and PFOS. In previous studies, significant expression of p53 was reported in several marine organisms including invertebrates (e.g., the copepod T. japonicus) and fish (Kryptolebias marmoratus and Gobiocypris rarus) exposed to diverse pollutants such as alkylphenols , gamma radiation Han et al, 2014b), and Aroclor 1254 (Wu et al, 2014). Tumor latency is significantly decreased in p53-deficient mice, indicating that the p53 gene plays a key protective role against genome instability, apoptosis, and DNA damage in response to radiation (Kemp et al, 1994).…”

Effect of polychlorinated biphenyls on osmoregulatory response and apoptosis in GIFT tilapia, Oreochromis niloticus

“…PCBs were purchased from Sigma-Aldrich (containing PCB28, PCB52, PCB101, PCB118, PCB138, PCB153, and PCB180 at 10 mg/L per congener). The exposure period followed that used by Eroglu and Canli (2013), and the concentrations were based on previous studies (Wu et al, 2014;Zhao et al, 2015). Fish were exposed to test solutions for 21 days and all exposure solutions were replenished every 48 h with fresh exposure solutions at the same concentration during the exposure experiment.…”

“…The concentration of polychlorinated biphenyls (PCBs) in the aquatic environment ranges from 1.7 to 29.8 ng/L in the Yangtze River, China (Ge et al, 2014). PCBs function as oxidative stress inducers to produce excess reactive oxygen species, which was shown to result in hepatotoxicity in the Chinese rare minnow (Gobiocypris rarus) (Wu et al, 2014). Na -ATPase (CMA) activity are the key endpoints in osmoregulatory pathway, while hepatic caspases are vital in apoptosis pathway.…”

Effect of polychlorinated biphenyls on oxidation stress in the liver of juvenile GIFT, Oreochromis niloticus

“…Furthermore, mRNA expression of antioxidant genes (sod, cat, and gpx1) was strongly enhanced in the Chinese rare minnow (Gobiocypris rarus) by Aroclor 1254 (a highly chlorinated PCB mixture Wu et al, 2014a). In addition to frequently used oxidative stress markers (SOD, CAT, and GPx), the GSH-related antioxidant system attempted to protect the liver cells of Oreochromes niloticus from hepatotoxicity (Piner and Üner, 2013), and markers in this system include GST, GR activity, GSH content, and the GSH/GSSG ratio among others.…”

“…Oxidative stress is an important manifestation in fish, and the oxidative damage induced by chemicals in aquatic ecosystems can be assessed through the measurement of antioxidative enzyme activities in fish. PCBs are oxidative stress inducers that produce excess reactive oxygen species (ROS), which could result in hepatotoxicity (Wu et al, 2014a). The primary ROS was generated in the mitochondria.…”