Induction of oxidative stress, DNA damage and apoptosis in mouse liver after sub-acute oral exposure to zinc oxide nanoparticles

Sharma, Vyom; Singh, Poonam; Pandey, Alok Kumar; Dhawan, Alok

doi:10.1016/j.mrgentox.2011.12.009

Cited by 415 publications

(289 citation statements)

References 40 publications

Supporting

Mentioning

262

Contrasting

Unclassified

Order By: Relevance

“…Delouise reported that ZNPs are nontoxic to cultured human dermal fibroblasts [13]. Other reports suggest that these nanoparticles are toxic to neuroblastoma cells [14], vascular endothelial cells [15], liver and kidneys [16,17]. In present study, toxic effects of ZNP on the mouse spermatogenesis were investigated.…”

Section: Introductionmentioning

confidence: 79%

The effect of zinc oxide nanoparticles on mouse spermatogenesis

Talebi

Khorsandi

Moridian³

2013

J Assist Reprod Genet

127

View full text Add to dashboard Cite

Objective To evaluate the effects of zinc oxide nanoparticles on mouse spermatogenesis. Methods Thirty two adult male NMRI mice were used. Experimental Groups (ZNP-1-ZNP-3) received one of the following treatments daily for 35 days: 5, 50 and 300 mg/kg zinc oxide nanoparticles respectively. Control group received only distilled water. Epididymal sperm parameters, testicular histopathology, morphometric analysis and spermatogenesis assessments were performed for evaluation of the zinc oxide nanoparticles effects on testis. Results Epididymal sperm parameters including sperm number, motility and percentage of abnormality were significantly changed in 50 and 300 mg/kg zinc oxide nanoparticles treated mice (p<0.01). Histopathological criteria such as epithelial vacuolization, sloughing of germ and detachment were significantly increased in 50 and 300 mg/kg zinc oxide nanoparticles treated mice (p<0.001). 300 mg/kg zinc oxide nanoparticles induced formation of multinucleated giant cells in the germinal epithelium. 50 and 300 mg/kg zinc oxide nanoparticles also caused a significant decrease in seminiferous tubule diameter, seminiferous epithelium height and maturation arrest (p<0.001). Conclusion Zinc oxide nanoparticles act as testicular toxicant and further studies are needed to establish its mechanism of action upon spermatogenesis.

show abstract

Section: Introductionmentioning

confidence: 79%

The effect of zinc oxide nanoparticles on mouse spermatogenesis

Talebi

Khorsandi

Moridian³

2013

J Assist Reprod Genet

127

View full text Add to dashboard Cite

show abstract

“…The observed results from the study demonstrated that the zinc oxide nanoparticles were toxic for the cells causing DNA damage and reduction in cell viability [216]. Another study focused on the assessment of in vivo toxicity of zinc nanoparticles at 14-20 μg/mL for 12 h to determine the effects of treatment on cell viability, DNA damage, ROS production and apoptosis [217]. When HEK 293 cell line was treated with 0-100 μg/mL zinc oxide nanoparticles for 24 h, it was observed that there was a reduction in cell viability.…”

Section: Mechanistic Studiesmentioning

confidence: 99%

In vitro and in vivo toxicity assessment of nanoparticles

2017

View full text Add to dashboard Cite

Nanotechnology has revolutionized gene therapy, diagnostics and environmental remediation. Their bulk production, uses and disposal have posed threat to the environment. With the appearance of these nanoparticles in the environment, their toxicity assessment is an immediate concern. This review is an attempt to summarize the major techniques used in cytotoxity determination. The review also presents a detailed and elaborative discussion on the toxicity imposed by different types of nanoparticles including carbon nanotubes, gold nanoparticles, silver nanoparticles, quantum dots, fullerenes, aluminium nanoparticles, zinc nanoparticles, iron nanoparticles, titanium nanoparticles and silica nanoparticles. It discusses the in vitro and in vivo toxological effects of nanoparticles on bacteria, microalgae, zebrafish, crustacean, fish, rat, mouse, pig, guinea pig, human cell lines and human. It also discusses toxological effects on organs such as liver, kidney, spleen, sperm, neural tissues, liver lysosomes, spleen macrophages, glioblastoma cells, hematoma cells and various mammalian cell lines. It provides information about the effects of nanoparticles on the gene-expression, growth and reproduction of the organisms.

show abstract

“…The atretic/healthy follicle ratio was significantly higher in examined sections of treated mice spleen compared with control group. The possible mechanism through which ZnO nanoparticles exert their toxic effects on human liver cells was investigated by Sharma et al [31]. The results demonstrate that ZnO nanoparticles accumulate in the tissues and induce intracellular reactive oxygen species (ROS) generation.…”

Section: Spleenmentioning

confidence: 99%

Treatment of Anemia Progression via Magnetite and Folate NanoparticlesIn Vivo

Elsayed¹,

Al-Sherbini

Abd-Elhady

et al. 2014

ISRN Nanotechnology

View full text Add to dashboard Cite

Iron deficiency anemia is a major global public health problem. Food fortification with iron (Fe) can be an effective strategy to control iron deficiency. An iron oxide nanoparticle (NP) is a new physical and chemical property form. These properties (small particle size, unique physical properties) make nanoiron a great scientific interest especially in the treatment of anemia. The study aimed to reduce anemia by nanoparticles (NPs). Forty-eight adult female Sprague-Dewily rats were divided into four groups (12 rats each). Group A represented a negative control. Other groups were fed standard diet iron free and three time of require zinc to reach anemic. Group B fed standard diet with ferrous sulfate until the improvement of the situation of anemia or for 8 weeks. Groups C and D were divided into three subgroups; each subgroup was fed a dose from magnetite or folate coated magnetite NPs. Results showed that symptoms of loss of appetite and severe lethargy demonstrate that magnetite and folate-coated magnetite nanoparticles have serious toxicological effects in vivo. Some doses from NPs improve blood picture during 2 weeks but change in histopathology examinations were occur in some groups within 2 weeks. Nanoparticles were considered the toxicological hazards especially the size of less than 54 nm.

show abstract

Induction of oxidative stress, DNA damage and apoptosis in mouse liver after sub-acute oral exposure to zinc oxide nanoparticles

Cited by 415 publications

References 40 publications

The effect of zinc oxide nanoparticles on mouse spermatogenesis

The effect of zinc oxide nanoparticles on mouse spermatogenesis

In vitro and in vivo toxicity assessment of nanoparticles

Treatment of Anemia Progression via Magnetite and Folate NanoparticlesIn Vivo

Contact Info

Product

Resources

About