2005
DOI: 10.1016/j.theriogenology.2004.09.008
|View full text |Cite
|
Sign up to set email alerts
|

Induction of parturition in the bitch with the progesterone-receptor blocker aglépristone

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

9
63
1
6

Year Published

2006
2006
2021
2021

Publication Types

Select...
5
3
1

Relationship

1
8

Authors

Journals

citations
Cited by 53 publications
(79 citation statements)
references
References 26 publications
9
63
1
6
Order By: Relevance
“…Although the mean gestational length in beef cattle used by Li et al (1991) and Dlamini et al (1995) was slightly longer than in Holstein cows used in our study (beef cows: 286G2.3 days; beef heifers: 284G1.5 days; Holstein: 280.5G1.3 days), uterine activation by upregulating a cassette of contraction-associated proteins and/or the conditioning of the systems providing uterotonins such as oxytocin and PGF 2a (Whittle et al 2001) -presumably by signals from the fetal side -may have been substantially different at the onset of antiprogestin treatment between the two experimental settings. A similar situation has been postulated for the dog, where, depending on the time of antiprogestin treatment, parturition with impaired or efficient (Baan et al 2005) expulsion of the puppies had been observed. The assumption that in our study antiprogestin treatment was started at an earlier stage of readiness for parturition compared with the study by Li et al (1991) and Dlamini et al (1995) is also substantiated by the observation that in our experiment calves from Ap-treated animals and from day 272 controls were viable but needed considerable clinical care during the first week after Figure 4 Concentrations of progesterone, estradiol 17b, estrone, and estrone sulfate in four untreated control cows during late gestation and around normal term.…”
Section: Discussionsupporting
confidence: 63%
“…Although the mean gestational length in beef cattle used by Li et al (1991) and Dlamini et al (1995) was slightly longer than in Holstein cows used in our study (beef cows: 286G2.3 days; beef heifers: 284G1.5 days; Holstein: 280.5G1.3 days), uterine activation by upregulating a cassette of contraction-associated proteins and/or the conditioning of the systems providing uterotonins such as oxytocin and PGF 2a (Whittle et al 2001) -presumably by signals from the fetal side -may have been substantially different at the onset of antiprogestin treatment between the two experimental settings. A similar situation has been postulated for the dog, where, depending on the time of antiprogestin treatment, parturition with impaired or efficient (Baan et al 2005) expulsion of the puppies had been observed. The assumption that in our study antiprogestin treatment was started at an earlier stage of readiness for parturition compared with the study by Li et al (1991) and Dlamini et al (1995) is also substantiated by the observation that in our experiment calves from Ap-treated animals and from day 272 controls were viable but needed considerable clinical care during the first week after Figure 4 Concentrations of progesterone, estradiol 17b, estrone, and estrone sulfate in four untreated control cows during late gestation and around normal term.…”
Section: Discussionsupporting
confidence: 63%
“…Our results also provide an explanation of the observation that aglepristone-induced parturition in the dog may require or may not require ecbolic support (Hoffmann et al 1999, Baan et al 2005. As provision of adequate amounts of PTGS2 seems to be restricted to the immediate phase prior to parturition, the time point of treatment with the antiprogestin seems to be the critical issue.…”
Section: Discussionmentioning
confidence: 54%
“…Blood samples for determination of the plasma concentrations of GH and IGF-I were collected before MPA treatment, at days À9, À8, À7, À5, À3, À2, À1, and 0 (=immediately before aglépristone treatment and after MPA treatment for over 1 year), at days 1, 3,5,7,8,11,13,15,18,20,22, and 25 (=during aglépristone treatment), and at days 46 and 60 (=3.5 and 5.5 weeks after the last aglépristone treatment). On days of treatment (MPA or aglépristone), blood samples were collected prior to the drug administration.…”
Section: Blood Sample Collectionmentioning
confidence: 99%
“…Aglépristone is the first progesterone receptor blocker licensed for veterinary use and has been used efficiently to terminate pregnancy [16,17] and to induce parturition [18]. Furthermore, it is successfully used for the treatment of fibroadenomatous mammary hyperplasia in cats [19][20][21] and may be a useful adjunct in the medical treatment of endometritis and pyometra in the dog [22].…”
Section: Introductionmentioning
confidence: 99%