Induction of periodontal destruction in gnotobiotic rats by a human oral strain of Actinomyces naeslundii

Socransky, S. S.; Hubersak, C.; Propas, D.

doi:10.1016/0003-9969(70)90095-6

Cited by 176 publications

(85 citation statements)

References 9 publications

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“…germfree (gnotobiotic) rodents has proven extremely useful in testing the pathogenic properties of specific bacterial species. This has been done by observing any pathological changes which may occur in these animals subsequent to monoinfection with a particular bacterial specie(s} (Socransky, Hubersak, andPropas, 1970, Jordan, Keyes, andBellack, 1972).…”

Section: Cervicoradicular Infections Have Been Induced In Rodents Bymentioning

confidence: 99%

“…The initiating role of bacteria in inflammatory gingival disease has been studied at length, especially over the last decade (Lee, Theilade, and Jensen, 1965, Socransky, Hubersak, and Propas, 1970, Jordan, Keyes, and Be1lack, 1972 with germfree rats, demonstrated periodontal inflammation could not occur in the absence of microorganisms. They observed both local irritation and bacteria were necessary to produce periodontal inflammation in their model.…”

Section: Cervicoradicular Infections Have Been Induced In Rodents Bymentioning

confidence: 99%

“…The humoral immune response in the host produces specific antibody as a result of the invasion by bacterial products acting as antigens (Nisengard and Beutner, 1970a, Gilmour and Nisengard, 19731. Numerous studies have been conducted implicating Actinomyces naeslundii as a primary etiologic agent in gingivitis and periodontitis (Socransky, Hubersak, andPropas, 1970, Marttala, Toto, andGargiulo, 1974). The antigenic activity of cell portions of A. naeslundii has been demonstrated (Irving, Heeley, and Socransky, 1975).…”

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confidence: 99%

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Experimental Gingivitis in the Albino Hamster

Ranieri

Toto

Gargiulo

1979

Journal of Periodontology

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Section: Cervicoradicular Infections Have Been Induced In Rodents Bymentioning

confidence: 99%

Section: Cervicoradicular Infections Have Been Induced In Rodents Bymentioning

confidence: 99%

mentioning

confidence: 99%

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Experimental Gingivitis in the Albino Hamster

Ranieri

Toto

Gargiulo

1979

Journal of Periodontology

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“…are also among the earliest colonizers of dental surfaces (2,3,7). These bacteria are present from infancy to adulthood and are involved in the initial stage of infectious disease development (3,(8)(9)(10)(11). The colonization of tooth or mucosal surfaces by Actinomyces spp.…”

Section: Introductionmentioning

confidence: 99%

Dynamic Changes in the Initial Colonization of Actinomyces naeslundii and Streptococcus gordonii Using a New Animal Model

Zhang

Senpuku

2013

Jpn J Infect Dis

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SUMMARY: Actinomyces naeslundii and Streptococcus gordonii are the predominant bacteria and initial colonizers of oral microflora. The binding of A. naeslundii and S. gordonii and the interaction between them on the salivary pellicle-coated tooth surface play an important role in the biofilm development. Recently, we reported that NOD/SCID.e2f1 -mice are a useful model for studying oral biofilm formation by Streptococcus mutans on the tooth surface. In this study, we aimed to determine whether NOD/SCID.e2f1 -mice can be used for studying oral colonization of A. naeslundii and S. gordonii. Colonization of A. naeslundii in mice fed with 1z sucrose water for 24 h before inoculation was higher than that among mice fed with sucrose water for 1 h. A. naeslundii colonization using mixed speciesinoculation was lower than that using single-species inoculation 30-90 min after inoculation; however, the colonization was higher 120-180 min after inoculation. The mixed inoculation induced better colonization of S. gordonii than single-species inoculation 60-180 min after inoculation. Polyclonal and fluorescein isothiocyanate-labeled antibody stained bacteria showed better colonization of S. gordonii when a mixed culture is used in vivo. NOD/SCID.e2f1 -mice were useful for studying the initial colonization of A. naeslundii and S. gordonii. Long-term supply of sucrose water creates a favorable environment for the initial colonization of A. naeslundii that, in turn, supports the colonization of S. gordonii.

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“…Dental caries and periodontal disease are caused by oral bacterial accumulation [1][2][3][4][5] . Bacterial adsorption to the salivary components of the oral tissue surface is observed before bacterial accumulation .…”

Section: Introductionmentioning

confidence: 99%

Adsorption of Saliva-coated and Just-harvested Streptococcus sanguis to Saliva-coated Hydroxyapatite Beads.

Tamura

Kuroda

Ueda

et al. 1995

The Journal of Nihon University School of Dentistry

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It is possible that salivary proteins on bacterial cells have some influence on the adsorption of oral bacteria to the surface of oral tissues. The aim of this study was to clarify the influence of salivary proteins attached to the surface of Streptococcus sanguis ATCC 10556 (S . sanguis) on bacterial adsorption to hydroxyapatite beads treated with salivary proteins (S-HA beads) . Just-harvested cells (N-system) and saliva-coated cells (C-system) were used .The results showed that adsorption to S-HA beads was gradually reduced by a covering of salivary proteins. No influence was observed on the adsorption of cells due to the presence of divalent cations , phosphate or EDTA when the N-system and C-system were compared. Though it was evident that hydrophobic bonding was involved in adsorption in the N-system , few such effects were observed in the C-system. Adsorption was inhibited to varying degrees by sugars in both systems . Pretreatment of cells with heat affected adsorption differently in the N-system and C-system. These findings suggest that salivary proteins attached to the bacterial cell surface may influence its adsorption to oral tissues.

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Induction of periodontal destruction in gnotobiotic rats by a human oral strain of Actinomyces naeslundii

Cited by 176 publications

References 9 publications

Experimental Gingivitis in the Albino Hamster

Experimental Gingivitis in the Albino Hamster

Dynamic Changes in the Initial Colonization of Actinomyces naeslundii and Streptococcus gordonii Using a New Animal Model

Adsorption of Saliva-coated and Just-harvested Streptococcus sanguis to Saliva-coated Hydroxyapatite Beads.

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