Induction of pregnancy-associated murine protein-1 in dwarf mice by human growth hormone

Abstract

SummaryPregnancy-associated murine protein-l (PAMP-l) could not be detected in peripheral blood of female dwarf mice (genotype dw/dw of the OW strain). By contrast the normal size females of the OW strain (genotypes + / + and + /dw) had PAMP-l serum levelsof 18·9 AU ± 15'7 AU/mI. Following administration of biosynthetic human growth hormone (hGH) every 2 h for 52 h PAMP-l was detected in all dwarf females at concentrations of 16·0 AU±3·3 AU/mI.The albumin levels in the circulation of OW females of normal size were significantly higher (P<0·05) than those of OW dwarfs, and the hGH administration did not change the serum albumin levels.The present experiment adds weight to the suggestion that the PAMP-l serum level is regulated by GH.