2015
DOI: 10.3791/51983
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Induction of Protein Deletion Through <em>In Utero</em> Electroporation to Define Deficits in Neuronal Migration in Transgenic Models

Abstract: Genetic deletion using the Cre-Lox system in transgenic mouse lines is a powerful tool used to study protein function. However, except in very specific Cre models, deletion of a protein throughout a tissue or cell population often leads to complex phenotypes resulting from multiple interacting mechanisms. Determining whether a phenotype results from disruption of a cell autonomous mechanism, which is intrinsic to the cell in question, or from a non-cell autonomous mechanism, which would result from impairment … Show more

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Cited by 3 publications
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References 28 publications
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