Induction of S100B Gene Expression in Long-Term Potentiation in the Hippocampal CA1 Field Depends on Activity of NMDA Receptors

Lisachev, P. D.; Pustylnyak, Vladimir O.; Штарк, М. Б.; Epstein, O. I.

doi:10.1007/s10517-013-1983-x

Cited by 4 publications

(13 citation statements)

References 14 publications

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“…Adenosine monophosphate deaminase (AMPD) is a very important regulator of muscle energy metabolism during exercise [5-7]. AMPD displaces the equilibrium of the myokinase reaction toward ATP production (2 ADP ↔ ATP + AMP) by converting AMP to inosine monophosphate (IMP) [5-9].…”

Section: Introductionmentioning

confidence: 99%

“…AMPD displaces the equilibrium of the myokinase reaction toward ATP production (2 ADP ↔ ATP + AMP) by converting AMP to inosine monophosphate (IMP) [5-9]. Moreover, the AMPD reaction is the initial reaction of the purine nucleotide cycle and plays a central role in the salvage of adenine nucleotides as well as the determination of energy charge [7,8]. Other important functions of the purine nucleotide cycle are the deamination of amino acids and the regulation of the glycolytic pathway by the formation of ammonia and IMP [7-9].…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, AMPD expression in skeletal muscle is dependent on muscle fibre composition [5,7-9]. In a sprint training study, a decrease in AMPD activity was reported concurrent with an increase in the proportion of fast-twitch (type II) fibres.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, two studies reported low frequency of the T allele in a group of top-level Spanish male endurance athletes [5] and Polish rowers [13] compared with controls. Several studies have shown that power-oriented athletes have a significantly lower frequency of the AMPD1 T allele than controls [7,14]. Varying findings reported by different groups of researchers show that at this point there is no consensus on the actual effect of AMPD1 polymorphisms on athletic performance.…”

Section: Introductionmentioning

confidence: 99%

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AMPD1 rs17602729 is associated with physical performance of sprint and power in elite Lithuanian athletes

et al. 2014

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BackgroundThe C34T genetic polymorphism (rs17602729) in the AMPD1 gene, encoding the skeletal muscle-specific isoform of adenosine monophosphate deaminase (AMPD1), is a common polymorphism among Caucasians that can impair exercise capacity. The aim of the present study was twofold: (1) to determine the C34T AMPD1 allele/genotype frequency distributions in Lithuanian athletes (n = 204, stratified into three groups: endurance, sprint/power and mixed) and compare them with the allele/genotype frequency distributions in randomly selected healthy Lithuanian non-athletes (n = 260) and (2) to compare common anthropometric measurements and physical performance phenotypes between the three groups of athletes depending on their AMPD1 genotype.ResultsThe results of our study indicate that the frequency of the AMPD1 TT genotype was 2.4% in the control group, while it was absent in the athlete group. There were significantly more sprint/power-orientated athletes with the CC genotype (86.3%) compared with the endurance-orientated athletes (72.9%), mixed athletes (67.1%), and controls (74.2%). We determined that the AMPD1 C34T polymorphism is not associated with aerobic muscle performance phenotype (VO2max). For CC genotype the short-term explosive muscle power value (based on Vertical Jump test) of athletes from the sprint/power group was significantly higher than that of the endurance group athletes (P < 0.05). The AMPD1 CC genotype is associated with anaerobic performance (Vertical Jump).ConclusionsThe AMPD1 C allele may help athletes to attain elite status in sprint/power-oriented sports, and the T allele is a factor unfavourable for athletics in sprint/power-oriented sports categories. Hence, the AMPD1 C allele can be regarded as a marker associated with the physical performance of sprint and power. Replications studies are required to confirm this association.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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AMPD1 rs17602729 is associated with physical performance of sprint and power in elite Lithuanian athletes

et al. 2014

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“…The mean of Ct values of five housekeeping genes (Actb, β -actin; B2m, beta-2 microglobulin; Hprt1, hypoxanthine phosphoribosyltransferase 1; Ldha, lactate dehydrogenase A; Rplp1, ribosomal protein, large, P1) was used as the reference according to manufacturer's instructions. The concentration of S100B mRNA was measured as described previously [68]. …”

Section: Methodsmentioning

confidence: 99%

Expression of p53 Target Genes in the Early Phase of Long-Term Potentiation in the Rat Hippocampal CA1 Area

2015

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Gene expression plays an important role in the mechanisms of long-term potentiation (LTP), which is a widely accepted experimental model of synaptic plasticity. We have studied the expression of at least 50 genes that are transcriptionally regulated by p53, as well as other genes that are related to p53-dependent processes, in the early phase of LTP. Within 30 min after Schaffer collaterals (SC) tetanization, increases in the mRNA and protein levels of Bax, which are upregulated by p53, and a decrease in the mRNA and protein levels of Bcl2, which are downregulated by p53, were observed. The inhibition of Mdm2 by nutlin-3 increased the basal p53 protein level and rescued its tetanization-induced depletion, which suggested the involvement of Mdm2 in the control over p53 during LTP. Furthermore, nutlin-3 caused an increase in the basal expression of Bax and a decrease in the basal expression of Bcl2, whereas tetanization-induced changes in their expression were occluded. These results support the hypothesis that p53 may be involved in transcriptional regulation during the early phase of LTP. We hope that the presented data may aid in the understanding of the contribution of p53 and related genes in the processes that are associated with synaptic plasticity.

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Insulin-induced long-term potentiation in the dentate gyrus of hippocampal formation

Barutçu

Süer

Dursun

et al. 2023

Psychoneuroendocrinology

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Induction of S100B Gene Expression in Long-Term Potentiation in the Hippocampal CA1 Field Depends on Activity of NMDA Receptors

Cited by 4 publications

References 14 publications

AMPD1 rs17602729 is associated with physical performance of sprint and power in elite Lithuanian athletes

AMPD1 rs17602729 is associated with physical performance of sprint and power in elite Lithuanian athletes

Expression of p53 Target Genes in the Early Phase of Long-Term Potentiation in the Rat Hippocampal CA1 Area

Insulin-induced long-term potentiation in the dentate gyrus of hippocampal formation

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