Induction of spermatogenesis in azoospermic men after internal spermatic vein embolization for the treatment of varicocele

Gat, Yigal; Bachar, Gideon; Everaert, Karel; Levinger, Uriel; Gornish, Michael

doi:10.1093/humrep/deh706

Cited by 96 publications

(65 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In cases in which there was no spontaneous pregnancy, the sperm improvement allowed an upgrade of ART, from ICSI to IVF and IUI. 17,29 Our results are consistent with the report by Osmonov et al, 17 who found that 53% of patients with initial non-obstructive azoospermia developed cryptozoospermia (OAT/OT syndrome) after AS, allowing ICSI as treatment. Another 60% of men with initial cryptozoospermia showed an improvement in the sperm count and motility.…”

Section: Discussionsupporting

confidence: 92%

The role of varicocele sclerotherapy in men with severe oligo-astheno-teratozoospermia

Ghanem¹,

Safan²,

Ghanem³

et al. 2011

Asian J Androl

View full text Add to dashboard Cite

The aim of this study was to verify the role of antegrade scrotal sclerotherapy for the treatment of varicoceles in infertile men with severe oligo-astheno-teratozoospermia (OAT). The 59 patients with severe OAT in this study underwent antegrade scrotal sclerotherapy for the treatment of varicoceles. The outcome was assessed in terms of improvement in semen parameters and spontaneous conception rate. Semen parameters and reproductive hormones were evaluated before antegrade sclerotherapy (AS) and 6 months after AS. After an average follow-up time of 34.863.2 months, significant improvement was noted in the mean sperm concentration, motility and morphology in 36 patients (61%). Spontaneous pregnancy occurred in nine couples (15%). Six months after treatment, inhibin B levels were significantly higher (P,0.04), whereas follicle-stimulating hormone (FSH) levels were significantly lower (P,0.001) than before treatment. Antegrade internal spermatic vein sclerotherapy can significantly improve seminal parameters and hormonal parameters in men with severe OAT and may even result in spontaneous pregnancy in couples who would otherwise be candidates for intracytoplasmic sperm injection (ICSI). 1 Several studies have confirmed an association between varicocele and testicular dysfunction, reflected by abnormal semen and the loss of testicular volume.

show abstract

Section: Discussionsupporting

confidence: 92%

The role of varicocele sclerotherapy in men with severe oligo-astheno-teratozoospermia

Ghanem¹,

Safan²,

Ghanem³

et al. 2011

Asian J Androl

View full text Add to dashboard Cite

show abstract

“…[10][11][12] There is also evidence to suggest that these positive changes in semen variables might translate into an improvement in male fertility potential, although in most studies it is difficult to evaluate the true improvement in pregnancy rates because a control group was not included. 13,14 In the current study, varicocelectomy was associated with a natural pregnancy rate of 16%, a result in keeping with that of published studies of varicocelectomy.…”

Section: Discussionsupporting

confidence: 90%

Postoperative outcomes of varicocelectomy and impact of on infertility among sample of patient in Baghdad, Iraq

2018

View full text Add to dashboard Cite

Background: Varicocele is the possible cause of 35% primary infertility, 70-80 % secondary and it is associated with progressive and duration dependent decline in testicular function. The aim of this study was to assess the postoperative outcome of varicocelectomy and determine positive impact on ability to reduce infertility.Methods: Twenty-five infertile male patients with varicocele, their age range from (20-40) year mean (30 year), were included and evaluated prospectively and retrospectively in Al-Karama teaching hospital from 2013-2016. Patients were divided in present study according to age of patient, degree of varicocele, duration of infertility and type of infertility. Site of varicocele was either left unilateral or bilateral. All the patients were treated surgically using three different approaches; Retroperitoneal approach, Inguinal and Sub inguinal approach and Scrotal approach.Results: It is noticeable that scrotal swelling was the most frequent complication and infection was the second highest. According to the age of patient, it was shown that beneficial effect of the Varicocelectomy was most favourable among younger age group. It is observables that favourable outcome was better among those with secondary fertility. It was found that grade III varicocele was associated with better outcome in terms of pregnancy and sperms motility.Conclusions: Scrotal swelling and infection was the most highly reported complication. Favourable effect of the Varicocelectomy was most among younger age group, secondary fertility and grade III varicocele.

show abstract

“…[46]. In two other articles, he described that the increased pressure at the PP * For some characteristics the number of patients does not equal the total number of adults or adolescents because we omitted patients in whom the characteristics could not be determined.…”

Section: Resultsmentioning

confidence: 99%

Contribution to the Pathophysiology and Treatment of Varicoceles

Vanlangenhove¹

2018

Journal of the Belgian Society of Radiology

View full text Add to dashboard Cite

Anatomical differences between adults and adolescents and between left and right varicoceles were shown in this work. We designed a standardized and reproducible method for pressure measurement in the inguinal internal spermatic vein (ISV). We demonstrated that the mean absolute pressure in the ISV in the upright position is higher than the veno-capillary pressure in the testicle, and hence could impair spermatogenesis prompting the need for treatment in varicoceles.Histoacryl transparent and Glubran2, the current commercially available adhesives for the treatment of varicoceles, do not differ with regard to efficiency, safety and tolerance during and after embolization. Both adhesives cause a mild pain in 30% of the patients in the week after embolization. The radiation exposure is low during embolizations of varicoceles with highly viscous liquid products. Therefore, the endovascular treatment with glue is an efficient, safe and tolerable method of treatment for varicoceles when applicable. Keywords: Varicocele; Embolization; Glue IntroductionThis thesis aimed at contributing to the pathophysiology and treatment of varicoceles. The research project encompasses five prospective studies and one retrospective study. The specific objectives of these clinical studies were to assess: (i) the safety, efficacy and tolerance of two types of glue and a non-gluing liquid embolic agent, in the endovascular treatment of varicoceles, (ii) to assess radiation burden for patient during varicocele embolization, (iii) to develop a standardized method to read the phlebographic anatomy of varicoceles and to test a different ontogenesis of varicoceles in adolescents and adults, and (iv) lastly to develop a standardized method to measure the intravascular pressure in the internal spermatic vein and to determine whether infertility in varicoceles can be explained by the principle of elevated hydrostatic pressure.

show abstract

Induction of spermatogenesis in azoospermic men after internal spermatic vein embolization for the treatment of varicocele

Cited by 96 publications

References 22 publications

The role of varicocele sclerotherapy in men with severe oligo-astheno-teratozoospermia

The role of varicocele sclerotherapy in men with severe oligo-astheno-teratozoospermia

Postoperative outcomes of varicocelectomy and impact of on infertility among sample of patient in Baghdad, Iraq

Contribution to the Pathophysiology and Treatment of Varicoceles

Contact Info

Product

Resources

About