Induction of Squamous Cell Carcinomas in the Salivary Glands of Rats by Potassium Iodide

Takegawa, Kiyoshi; Mitsumori, Kunitoshi; Oda, Hiroshi; Yasuhara, Kazuo; Kitaura, Keisuke; Shimo, Tsuyoshi; Takahashi, Michihito

doi:10.1111/j.1349-7006.1998.tb00536.x

Cited by 16 publications

(13 citation statements)

References 19 publications

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“…The transformation of squamous metaplasia into squamous cell carcinoma cannot be excluded and should be considered in determining the prognosis. 41 Close monitoring of the patient and a review conducted at 18 months postoperatively confirmed no recurrence and no development of malignant change. Further, it seems that the persistent pleomorphic adenoma in the patient's lower lip was a major factor contributing to the severe gingival recession around lower central incisors.…”

Section: Discussionmentioning

confidence: 81%

Pleomorphic Adenoma in the Lower Lip: A Case Report and a Review

Nourwali

Dar‐Odeh

2019

Eur J Dent

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Pleomorphic adenoma constitutes 50% of salivary gland tumors affecting mostly the parotid gland extraorally, and the palate intraorally. While the upper lip is a common site, it is unusual to encounter this tumor in the lower lip. A 26-year-old man complained of a persistent lump affecting the lower lip. The lesion was excised and was shown on histopathological examination to be a pleomorphic adenoma with squamous metaplasia. At the 18-month review appointment, there was complete healing and no recurrence. Pleomorphic adenoma in the lower lip should be considered among the differential diagnosis of lower labial swellings, especially in young patients. There needs to be reconsideration of the epidemiological and histological characteristics.

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Section: Discussionmentioning

confidence: 81%

Pleomorphic Adenoma in the Lower Lip: A Case Report and a Review

Nourwali

Dar‐Odeh

2019

Eur J Dent

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“…On the other hand, it has been reported that intake of high doses of I Ϫ can promote cancer in animals. 33) In the present study, I Ϫ efficiently inhibited the reaction of nucleosides, especially dG, with the myeloperoxidase-H 2 O 2 -Cl Ϫ system. However, since the plasma concentration of I Ϫ is low (0.46-0.67 mM), 16) it is unlikely that I Ϫ affects nucleoside damage caused by myeloperoxidase in plasma.…”

Section: Brmentioning

confidence: 97%

Modification by Fluoride, Bromide, Iodide, Thiocyanate and Nitrite Anions of Reaction of a Myeloperoxidase-H2O2-Cl- System with Nucleosides.

Suzuki

Ohshima

2003

CHEMICAL & PHARMACEUTICAL BULLETIN

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Hypochlorous acid (HOCl) is generated as an endogenous product of the respiratory burst in mammalian neutrophils by myeloperoxidase from hydrogen peroxide (H 2 O 2 ) and chloride (Cl Ϫ ).1) HOCl generated by myeloperoxidase is of central importance in immune surveillance and host defense mechanisms. However, it also has potential to harm normal tissue and contribute to inflammatory injury. Indeed, reagent HOCl and/or the myeloperoxidase-H 2 O 2 -Cl Ϫ system have been reported to react with nucleic acid bases to form various compounds. [2][3][4][5][6][7][8] We have examined the reaction of 2Ј-deoxyguanosine (dG) with reagent HOCl and/or the myeloperoxidase-H 2 O 2 -Cl Ϫ system and found that a diimino-imidazole nucleoside, an amino-imidazolone nucleoside, a spiroiminodihydantoin nucleoside and 8-chloro-2Ј-deoxyguanosine were generated. reported that 8-nitro-2Ј-deoxyguanosine was generated by the reaction of dG with the myeloperoxidase-H 2 O 2 -Cl Ϫ system in the presence of NO 2 Ϫ at plasma concentrations of Cl . These papers showed that NO 2 Ϫ and Br Ϫ were significant regents with respect to nucleoside damage caused by the myeloperoxidase-H 2 O 2 -Cl Ϫ system. However, in these studies and others of damage caused by myeloperoxidase, specific products and their yields were determined, but data for the whole reaction, i.e., for consumption of the target nucleosides, were extremely limited.In the present study, we investigated the reaction of a nucleoside mixture with the myeloperoxidase-H 2 O 2 -Cl Ϫ system in the presence of various anions including F , and the consumption of each nucleoside was determined by HPLC. Results and Discussion pH-Dependence of the Reaction of the Nucleoside Mixture with the Myeloperoxidase-H 2 O 2 -Cl؊ System A nucleoside mixture (dG, dC, 2Ј-deoxythymidine (dT) and 2Ј-deoxyadenosine (dA); 100 mM each) was incubated with 50 nM myeloperoxidase in 100 mM sodium phosphate buffers of different pH with 200 mM H 2 O 2 and 100 mM NaCl at 37°C for 30 min. The reaction was terminated by addition of Nacetylcysteine. The reaction mixture was analyzed by reversed-phase HPLC to determine the remaining concentration of each nucleoside. Figure 1 shows a plot of the concentrations of nucleosides versus pH. Consumption of nucleosides was observed under mildly acidic conditions. The myeloperoxidase-H 2 O 2 -Cl Ϫ system consumed nucleosides in the following order: dGϾdCϾ ϾdTϾdAÅ0. The optimal pH for consumption of nucleosides was 4.7. At pH 4.7, total consumption was 67.3 mM corresponding to 33.7% relative to H 2 O 2 added.It has been reported that dC reacts with a myeloperoxi-

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“…Squamous cell metaplasia was induced with chlorodibromomethane in F344 rats but not in B6C3F1 mice after 13-week treatment, but no tumor progression was noted after 2 years treatment ( Dunnick et al 1985 ). On the other hand, transition of squamous metaplasia into squamous cell carcinoma in the submandibular gland via a non-genotoxic, proliferation-dependent mechanism was postulated after 2-year treatment with potassium iodide in F344 rats ( Takegawa et al 1998 ). In addition, in experiments with implanted sponge pellets containing DMBA inducing squamous cell carcinomas in Sprague-Dawley rats, the authors concluded that ductal segments undergoing squamous cell metaplasia may have participated in the genesis of neoplasia during experimental carcinogenesis ( Cao et al 2000 , Sumitomo et al 1996 ).…”

Section: Salivary Glandsmentioning

confidence: 99%

“…Few carcinomas and adenocarcinomas have been reported in mice and rats ( Botts et al 1999 ; Hosokawa et al 2000 ; Nishikawa et al 2010 ; Tsunenari et al 1997 ). Malignant tumors in the salivary glands may be induced with chemical substances in rats ( Neuenschwander and Elwell 1990 ; Sumitomo et al1996 ; Cao et al 1999 ; Zaman et al 1996 ) and mice ( Botts et al 1999 ; Takegawa et al 1998 ; Takai et al 1986 ; Yura et al 1995 ) or in various transgenic animal models ( Dardick et al 2000 ; Declercq et al 2005 ; Nielsen et al 1991 ; Nielsen et al 1995 ).…”

Section: Salivary Glandsmentioning

confidence: 99%

Nonproliferative and Proliferative Lesions ofthe Gastrointestinal Tract, Pancreas andSalivary Glands of the Rat and Mouse

et al. 2016

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The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) project is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP), and North America (STP) to develop an internationally accepted nomenclature and diagnostic criteria for nonproliferative and proliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature and diagnostic criteria for classifying lesions in the digestive system including the salivary glands and the exocrine pancreas of laboratory rats and mice. Most lesions are illustrated by color photomicrographs. The standardized nomenclature, the diagnostic criteria, and the photomicrographs are also available electronically on the Internet (http://www.goreni.org/). Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous and age related lesions as well as lesions induced by exposure to test items. Relevant infectious and parasitic lesions are included as well. A widely accepted and utilized international harmonization of nomenclature and diagnostic criteria for the digestive system will decrease misunderstandings among regulatory and scientific research organizations in different countries and provide a common language to increase and enrich international exchanges of information among toxicologists and pathologists.

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Induction of Squamous Cell Carcinomas in the Salivary Glands of Rats by Potassium Iodide

Cited by 16 publications

References 19 publications

Pleomorphic Adenoma in the Lower Lip: A Case Report and a Review

Pleomorphic Adenoma in the Lower Lip: A Case Report and a Review

Modification by Fluoride, Bromide, Iodide, Thiocyanate and Nitrite Anions of Reaction of a Myeloperoxidase-H2O2-Cl- System with Nucleosides.

Nonproliferative and Proliferative Lesions ofthe Gastrointestinal Tract, Pancreas andSalivary Glands of the Rat and Mouse

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