Induction of tolerance via skin depleted of langerhans cells by a chemical carcinogen

Halliday, GM; Hk, Müller

doi:10.1016/0008-8749(86)90230-3

Cited by 41 publications

(16 citation statements)

References 36 publications

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“…The following parameters have been reportedly affected in DMBA-exposed mice: proliferative response to T cell mitogens, unidirectional mixed lymphocyte response, generation of cytotoxic lymphocytes, and NK cell tumor cytolysis (14,15). Application of DMBA to the skin depletes epidermal Langerhans cells (LCs) (16) and suppresses CHS locally, when a sensitizer is applied to DMBA-treated skin (17)(18)(19). Similar to UVB-induced immunosuppression, DMBA-induced local immunosuppression is reported to be associated with the development of Ag-specific suppressor T lymphocytes, which inhibit the induction of both cellular and humoral immune responses when adoptively transferred to naive syngeneic recipients (17,18).…”

Section: Eroderma Pigmentosum (Xp)mentioning

confidence: 99%

“…Application of DMBA to the skin depletes epidermal Langerhans cells (LCs) (16) and suppresses CHS locally, when a sensitizer is applied to DMBA-treated skin (17)(18)(19). Similar to UVB-induced immunosuppression, DMBA-induced local immunosuppression is reported to be associated with the development of Ag-specific suppressor T lymphocytes, which inhibit the induction of both cellular and humoral immune responses when adoptively transferred to naive syngeneic recipients (17,18). In contrast to UVB, topically applied DMBA inhibits cutaneous immunological functions only at the site of application, because when DMBA is applied at one skin site, and animals are immunized to the hapten at another site, a normal CHS response is observed (18).…”

Section: Eroderma Pigmentosum (Xp)mentioning

confidence: 99%

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Carcinogen-Induced Inflammation and Immunosuppression Are Enhanced in Xeroderma Pigmentosum Group A Model Mice Associated with Hyperproduction of Prostaglandin E2

Miyauchi-Hashimoto

Kuwamoto

Urade³

et al. 2001

The Journal of Immunology

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Xeroderma pigmentosum group A (XPA) gene-deficient mice easily developed skin cancers by the application of topical chemical carcinogens as well as by UV irradiation. As certain chemical carcinogens have been shown to be immunosuppressive, we examined the inflammatory and immunosuppressive effects of dimethylbenz(a)anthracene (DMBA) on XPA mice. Compared with wild-type mice, XPA mice showed greater ear swelling and reduction of epidermal Langerhans cells after DMBA application. Topical application of DMBA impaired the induction of contact hypersensitivity, initiated either locally or at distant sites. These DMBA-induced local and systemic immunosuppressions were more greatly enhanced in XPA mice than in wild-type mice. DMBA application induced pronounced production of PGE2, IL-10, and TNF-α in the skin of XPA mice. Treatment with indomethacin, a potent inhibitor of PG biosynthesis, inhibited DMBA-induced inflammation and local immunosuppression. In XPA mice, increased serum IL-10 was detected after DMBA treatment. Excess production of PGE2, TNF-α, and IL-10 after DMBA application may be involved in the enhanced local and systemic immunosuppression in DMBA-treated XPA mice. Susceptibility to DMBA-induced skin tumors in XPA mice may be due to easy impairment of the immune system by DMBA in addition to a defect in the repair of DMBA-DNA adduct. Enhanced immunosuppression by chemical carcinogens as well as the mutagenicity of these mutagens might be associated with the high incidence of internal malignancies seen in XP patients. Moreover, these results supported the hypothesis that persistent DNA damage is a trigger for the production of immunoregulatory cytokines.

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Section: Eroderma Pigmentosum (Xp)mentioning

confidence: 99%

Section: Eroderma Pigmentosum (Xp)mentioning

confidence: 99%

Carcinogen-Induced Inflammation and Immunosuppression Are Enhanced in Xeroderma Pigmentosum Group A Model Mice Associated with Hyperproduction of Prostaglandin E2

Miyauchi-Hashimoto

Kuwamoto

Urade³

et al. 2001

The Journal of Immunology

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“…9,10-Dimethyl-1,2-benzanthracene (DMBA) was the first chemical agent observed to effectively deplete LCs from the epidermis, as determined by ultrastructural examination (Halliday and Muller 1986). When transplanted onto MHCmismatched recipients, DMBA-treated mouse skin grafts had a prolonged survival time compared to control skin grafts (Odling et al 1987b).…”

Section: Depletion Of Donor-derived Dcsmentioning

confidence: 99%

Fundamental Immunology of Skin Transplantation and Key Strategies for Tolerance Induction

Zhou

Wang

Luo

et al. 2013

Arch. Immunol. Ther. Exp.

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Transplantation of allogeneic or xenogeneic skin grafts can evoke strong immune responses that lead to acute rejection of the graft tissues. In this process, donor-derived dendritic cells play crucial roles in the triggering of such immune responses. Both the innate and acquired host immune systems participate in graft rejection. At present, the rejection of skin grafts cannot be well-controlled by ordinary systemic immunosuppression therapy. Although several strategies for the long-term survival of allogeneic or xenogeneic skin grafts have been demonstrated in animal models, the induction of long-term tolerance to skin grafts is still a great challenge in clinical settings. In this article, we review the progress in the understanding of immune responses to skin grafts and discuss the possible methods that can decrease the immunogenicity of graft tissues and improve the survival of skin grafts, especially those included in preoperative pre-treatments.

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“…Langerhans cells (LC) are an essential component of cutaneous immunological defence mechanisms (Halliday & Muller, 1984). They are bone-marrow derived cells (Stingl et al, 1980), which in the epidermis form a continuous network of cells linked to each other via their dendritic processes .…”

mentioning

confidence: 99%

“…LC are an essential component of cutaneous immunological defence mechanisms (Halliday & Muller, 1984), and therefore any potential tumour cells may be inhibited from growing into a tumour by the LC presenting tumour-associated-antigens to T cells, thus indLucing an anti-tumour immune response. Depletion of LC by a promotor might enable potential tumour cells to grow into a tumour unhindered by an immune response.…”

mentioning

confidence: 99%

Tumour promoters but not initiators deplete Langerhans cells from murine epidermis

Halliday

MacCarrick²,

Muller³

1987

Br J Cancer

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Induction of tolerance via skin depleted of langerhans cells by a chemical carcinogen

Cited by 41 publications

References 36 publications

Carcinogen-Induced Inflammation and Immunosuppression Are Enhanced in Xeroderma Pigmentosum Group A Model Mice Associated with Hyperproduction of Prostaglandin E2

Carcinogen-Induced Inflammation and Immunosuppression Are Enhanced in Xeroderma Pigmentosum Group A Model Mice Associated with Hyperproduction of Prostaglandin E2

Fundamental Immunology of Skin Transplantation and Key Strategies for Tolerance Induction

Tumour promoters but not initiators deplete Langerhans cells from murine epidermis

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