2010
DOI: 10.1523/jneurosci.3315-10.2010
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Induction of Vertebrate Regeneration by a Transient Sodium Current

Abstract: Amphibians such as frogs can restore lost organs during development, including the lens and tail. To design biomedical therapies for organ repair, it is necessary to develop a detailed understanding of natural regeneration. Recently, ion transport has been implicated as a functional regulator of regeneration. Whereas voltage-gated sodium channels play a well known and important role in propagating action potentials in excitable cells, we have identified a novel role in regeneration for the ion transport functi… Show more

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Cited by 185 publications
(221 citation statements)
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References 56 publications
(68 reference statements)
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“…Re-emerging bioelectric studies are revealing transduction mechanisms. V-ATPase-mediated repolarization of membrane potential (V m ) and voltage-gated Na + channel (VGSC or Na V ) 1.2-mediated sodium influx are necessary for and sufficient to induce X. laevis tadpole tail regeneration (Adams et al, 2007;Tseng et al, 2010). V-ATPase proton efflux activity correlates with regeneration rate and ability in zebrafish caudal fin regeneration (Monteiro et al, 2014).…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Re-emerging bioelectric studies are revealing transduction mechanisms. V-ATPase-mediated repolarization of membrane potential (V m ) and voltage-gated Na + channel (VGSC or Na V ) 1.2-mediated sodium influx are necessary for and sufficient to induce X. laevis tadpole tail regeneration (Adams et al, 2007;Tseng et al, 2010). V-ATPase proton efflux activity correlates with regeneration rate and ability in zebrafish caudal fin regeneration (Monteiro et al, 2014).…”
Section: Introductionmentioning
confidence: 99%
“…Interestingly, redox and bioelectric activities control the expression and activity of signaling pathways, such as Wnt, FGF, BMP and Notch, in addition to cell behaviors, such as proliferation, apoptosis and innervation, which are required for regeneration (Adams et al, 2007;Gauron et al, 2013;Han et al, 2014;Love et al, 2013;Monteiro et al, 2014;Tseng et al, 2010). Redox (ROS) and bioelectric [V m , TEP, electric fields (EF) and J I ] states therefore affect regeneration.…”
Section: Introductionmentioning
confidence: 99%
“…Patterning and size control during development and regeneration are also regulated by bioelectric signaling (52,(71)(72)(73)(74)(75)(76)(77)(78). Mutations in two strains of zebrafish with fin size phenotypes map to genes involved in bioelectric signaling (41,79).…”
Section: Discussionmentioning
confidence: 99%
“…Such patterns of resting potential within living tissues (bioelectric signals) have been studied in the context of their roles in cell migration and wound healing (Cao et al, 2013, Jaffe, 1979, McCaig et al, 2005, Richard B. Borgens, 1989, Zhao et al, 2006 and have long been proposed to direct growth and form in vivo (Burr, 1932). Bioelectric signals are implicated in vertebrate appendage regeneration , Tseng et al, 2010, cancer initiation and metastasis (Binggeli and Weinstein, 1986b, Blackiston et al, 2011, Brackenbury, 2012, Chernet and Levin, 2013b, Lobikin et al, 2012b, left-right patterning (Aw et al, 2008, Aw et al, 2010, Levin et al, 2002, planarian head induction (Beane et al, 2011, Beane et al, 2013, Marsh and Beams, 1947, and eye and brain formation (Nuckels et al, 2009, Pai et al, 2015, Pai et al, 2012a, Pai et al, 2012b. Thus bioelectric signals have been shown to be important regulators of large-scale patterning and tissue and organ identity (Levin, 2009, Levin, 2013a, Levin and Stevenson, 2012, Tseng and Levin, 2013a.…”
Section: Introductionmentioning
confidence: 99%