2002
DOI: 10.1111/j.1432-2277.2002.tb00201.x
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Induction therapy including antithymocyte globulin induces marked alterations in T lymphocyte subpopulations after liver transplantation: results of a long-term study

Abstract: Various immunosuppressive regimens aim to reduce the incidence of acute rejection after liver transplantation. The efficacy of antithymocyte globulin (ATG) induction therapy and short-term effects on the cellular response have been demonstrated in several studies. Nevertheless, information about long-term effects of ATG therapy on cellular responses and frequency of complications is limited. Therefore, we analyzed the effect of ATG administration within a cyclosporine-based induction therapy, including azathio… Show more

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Cited by 20 publications
(12 citation statements)
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“…Liver transplantation recipients receiving induction therapy with ATG showed persistently higher levels of CD8 ϩ CD57 ϩ lymphocytes in the late postoperative phase than recipients not treated with ATG, which was not associated with any clinical effect [132]. The same effect was seen in pediatric renal transplant recipients [133].…”
Section: Cd57 ؉ T Lymphocytes In Allogeneic Transplantationmentioning
confidence: 78%
“…Liver transplantation recipients receiving induction therapy with ATG showed persistently higher levels of CD8 ϩ CD57 ϩ lymphocytes in the late postoperative phase than recipients not treated with ATG, which was not associated with any clinical effect [132]. The same effect was seen in pediatric renal transplant recipients [133].…”
Section: Cd57 ؉ T Lymphocytes In Allogeneic Transplantationmentioning
confidence: 78%
“…Yet another hypothesis is that it could be the immunosuppressive therapy for rejection, and not rejection per se, that predisposes to recurrent PSC 12. Indeed, some immunosuppressants, such as calcineurin inhibitors20, 21 and antithymocyte globulin22 have been associated with reduced numbers of CD4+ CD25+ regulatory T cells. The latter have been strongly implicated in preventing murine models of IBD, and so may likewise have a role in preventing human PSC, such that their depletion with immunosuppressive medications could paradoxically facilitate PSC recurrence after OLT.…”
Section: Discussionmentioning
confidence: 99%
“…Initial and long‐term kidney function was not influenced by TMG induction therapy, probably because Tac was immediately administrated after LT. A higher rate of infectious complications (bacterial and CMV) was observed in the TMG+ group; nevertheless, the difference did not reach statistical significance. The presence of cross‐reacting antibodies directed against nonlymphoid cells is known to be responsible for the possible leukopenia observed in association with TMG therapy 32. This was confirmed in our trial, with significantly lower mean values for the white blood cell count in the TMG+ group during the first 90 days following transplantation and with a significantly higher number of patients reported with leukopenia in the TMG+ group (86%) versus the TMG− group (64%) during the 5 years following transplantation.…”
Section: Discussionmentioning
confidence: 99%