Inductive Properties of Hair Follicle Cells

Reynolds, Amanda J.; Jahoda, Colin A.B.

doi:10.1111/j.1749-6632.1991.tb24390.x

Cited by 72 publications

(17 citation statements)

References 20 publications

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“…Between E10.5 and E12.5, loose mesenchyme cells migrate to the subectodermal region and become specified to dermal fibroblast precursors (Atit et al, 2006;Dhouailly et al, 2004;Ohtola et al, 2008;Tran et al, 2010). The dermal fibroblast precursors then differentiate into matrix-secreting dermal fibroblasts or dermal condensate, dermal papillae and dermal sheath cells that are induced by the developing hair follicle (Dhouailly et al, 2004;Reynolds and Jahoda, 1991).…”

Section: Introductionmentioning

confidence: 99%

Dermal β-catenin activity in response to epidermal Wnt ligands is required for fibroblast proliferation and hair follicle initiation

et al. 2012

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SUMMARYDermal fibroblasts are required for structural integrity of the skin and for hair follicle development. Uniform Wnt signaling activity is present in dermal fibroblast precursors preceding hair follicle initiation, but the functional requirement of dermal Wnt signaling at early stages of skin differentiation and patterning remains largely uncharacterized. We show in mice that epidermal Wnt ligands are required for uniform dermal Wnt signaling/-catenin activity and regulate fibroblast cell proliferation and initiation of hair follicle placodes. In the absence of dermal Wnt signaling/-catenin activity, patterned upregulation of epidermal -catenin activity and Edar expression are absent. Conversely, forced activation of -catenin signaling leads to the formation of thickened dermis, enlarged epidermal placodes and dermal condensates that result in prematurely differentiated enlarged hair follicles. These data reveal functional roles for dermal Wnt signaling/-catenin in fibroblast proliferation and in the epidermal hair follicle initiation program.

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Section: Introductionmentioning

confidence: 99%

Dermal β-catenin activity in response to epidermal Wnt ligands is required for fibroblast proliferation and hair follicle initiation

et al. 2012

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“…5 Specific differences in fibroblast physiology are evident in papillary dermal fibroblasts, which reside in the superficial dermis, and reticular fibroblasts, which reside in the deep dermis. 6 Another subpopulation of fibroblasts is associated with hair follicles 7 and engages in fibroblast-epidermal interactions during hair development and in interfollicular regions of skin.…”

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confidence: 99%

“…5,[8][9][10] Fibroblasts associated with hair follicles also show a distinctive characteristic such as different amounts of protein production and are different from the cells in the papillary and reticular dermis. 7,11 Studies have demonstrated that dermal fibroblasts present even within the same tissue sample are heterogeneous and their microenvironmental localization might be one of the main reasons for fibroblast heterogeneity. 12 Studies have also demonstrated that the superficial papillary dermis contains a heterogeneous population of fibroblasts, and propose that diverse subpopulations of fibroblasts are required to interact in both homeostatic and pathological situations in the skin.…”

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confidence: 99%

Deep dermal fibroblasts contribute to hypertrophic scarring

Wang

Dodd

Shankowsky

et al. 2008

Laboratory Investigation

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Hypertrophic scar (HTS) following thermal injury is a dermal fibroproliferative disorder that leads to considerable morbidity. The development of HTS involves numerous cell types and cytokines with dermal fibroblasts being a key cell. We have previously reported that the phenotype of fibroblasts isolated from HTS was altered compared to fibroblasts from normal skin. In this study, normal skin was horizontally sectioned into five layers using a dermatome from which fibroblasts were isolated and cultured. Cells from the deeper layers were observed to proliferate at a slow rate, but were morphologically larger. In ELISA and FACS assays, cells from the deeper layers produced more TGF-b1 and TGF-b1 producing cells were higher. In quantitative RT-PCR, the cells from the deeper layers had higher CTGF and HSP47 mRNA levels compared to those from superficial layers. In western blot, FACS and collagen gel assays, fibroblasts from the deeper layers produced more a-smooth muscle actin (a-SMA), had higher a-SMA positive cells and contracted collagen gels more. Fibroblasts from the deeper layers were also found to produce more collagen, but less collagenase by mass spectrometry and collagenase assay. Interestingly, cells from the deeper layers also produced more of the proteoglycan, versican, but less decorin. Taken together, these data strongly demonstrate that fibroblasts from the deeper layers of the dermis resemble HTS fibroblasts, suggesting that the deeper layer fibroblasts may be critical in the formation of HTS. Hypertrophic scarring is a common fibroproliferative disorder of the human dermis characterized by erythematous, raised, pruritic lesions of the healing skin, which is usually following thermal and other injuries that involve the deep dermis. 1 These lesions lead to scarring that compromises the appearance of healing skin and are commonly associated with contractures that limit movement and function of involved joints and facial features. As such, HTS is the principal factor that contributes to the prolonged and often uncomfortable rehabilitation period for thermally injured patients, particularly those who have survived large lifethreatening injuries, children, and individuals of dark-skinned races, in whom such scarring occurs more commonly. 2 The undesirable physical properties of HTS tissue can be attributed to the presence of a large amount of extracellular matrix that is of altered composition and organization, compared to normal dermis or mature scar. This matrix is the product of a dense population of fibroblasts, maintained in a hyperactive state by inflammatory cytokines such as TGF-b and other factors, some of which may be physical in origin. 3 Although the molecular and cellular events that lead to HTS have been extensively studied, the pathogenesis of this condition is still not well understood, making treatment difficult.Key cells involved in HTS are the dermal fibroblasts. Dermal fibroblasts are a dynamic and diverse population of cells whose function in skin and HTS in many respects remain unkn...

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“…To the Editor, Dermal papilla (DP) is situated at the base of hair follicle and is known to play an essential role in the induction and maintenance of hair growth [1]. Cultured dermal papilla cells exhibit normal fibroblastlike morphology at early passage [2], however, in contrast to interfollicular dermal fibroblast (DF), only dermal papilla cells can induce new hair follicle growth in vivo [3].…”

mentioning

confidence: 99%