Industrial Contamination with Glycol Ethers Resulting in Teratogenic Damage

Saavedra, Dolores; Arteaga, Manuel; Tena, Martha

doi:10.1111/j.1749-6632.1997.tb56870.x

Cited by 12 publications

(17 citation statements)

References 7 publications

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“…In the previous research, in which the solvents were independently applied (Saavedra-Ontiveros et al;Saavedra et al, 1997) generalized edema was also observed, more severely in the methyl cellosolve-treated rats than in the ethylene glycol-treated rats, but both with a lower frequency and at a higher dose than those used in this study, indicating that this effect is stronger when mixing the solvents.…”

Section: Discussionsupporting

confidence: 58%

“…A few years ago, we demonstrated the teratogenic effect of ethylene glycol and methyl cellosolve, when applying each one of them independently in gestating Wistar rats (Saavedra-Ontiveros et al, 1996;Saavedra et al, 1997;Saavedra et al, 1998). That research was performed to complete the clinical and epidemiological study of a group of patients of a border city of the north of Mexico, whose mothers had been in contact with a mixture of these solvents during the gestation of the patients (Saavedra-Ontiveros et al, 1996;Saavedra et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

“…That research was performed to complete the clinical and epidemiological study of a group of patients of a border city of the north of Mexico, whose mothers had been in contact with a mixture of these solvents during the gestation of the patients (Saavedra-Ontiveros et al, 1996;Saavedra et al, 1997). The alterations found in the fetuses from the rats exposed to ethylene glycol were more or less similar to those observed in the fetuses exposed to methyl cellosolve, and some of these characteristics were also similar or equivalent to those observed in the patients.…”

Section: Discussionmentioning

confidence: 99%

“…This gave rise to the establishment of a new teratogenic syndrome, not previously described, originated by the prenatal exposure to industrial solvents: ethylene glycol (HO-CH 2 -CH 2 -OH) and methyl cellosolve (HO-CH 2 -CH 2 -O-CH 3 ) (Saavedra-Ontiveros et al, 1996;Saavedra et al, 1997;Saavedra et al, 1998). The teratogenic action of each one of the solvents was confirmed in an experimental study in rats, and found morphological alterations more or less similar to those observed in the patients, as well as microscopic alterations of the central nervous system compatible with the functional alterations observed in the patients (Saavedra-Ontiveros et al;Saavedra et al, 1997;Saavedra et al, 1998). maintained under the same conditions as the other groups.…”

Section: Introductionmentioning

confidence: 99%

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Teratogenic Effect of Ethylene Glycol-Methyl Cellosolve Mixture in Rats: II. Craniofacial and Limb Abnormalities

et al. 2010

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SUMMARY:We investigated the teratogenic effect of an ethylene glycol-methyl cellosolve mixture on gestating Wistar rats, that received a daily intraperitoneal dose of different concentration of the mixture on day 8 of gestation until day 20. Multivariate analysis and Post-Hoc Bonferroni tests were used and relative risk and attributable fraction were calculated. In rats treated with the mixture the number of live fetuses decreased and reabsorptions increased with increasing concentrations of the mixture, as well as the number of abnormal fetuses. Abnormalities consisted mainly in atypical craniofacial morphology, protruding tongue, edema, signs of growth delay and shorter limbs, their frequency and severity increased at higher concentrations of the mixture. We conclude that the ethylene glycol-methyl cellosolve mixture possesses a higher teratogenic potential than each of its constituents separately, producing external fetal abnormalities, growth delay, and increased fetal death.

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Section: Discussionsupporting

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Teratogenic Effect of Ethylene Glycol-Methyl Cellosolve Mixture in Rats: II. Craniofacial and Limb Abnormalities

et al. 2010

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“…Hohe Exposition am Arbeitsplatz gegenüber EGME während der Schwangerschaft ist mit bleibenden zytogenetischen Veränderungen und Fehlbildungen assoziiert, was eine Einstufung als humanes Teratogen rechtfertigt. Saavedra et al [42] berichten über angeborene Missbildungen mit unterschiedlichen Graden der geistigen Behinderung bei 44 Nachkommen, deren Mütter während der Schwangerschaft in einer mexikanischen Fabrik beruflich gegenüber EGME und Ethylenglykol exponiert worden waren.…”

Section: Menschunclassified

Bekanntmachung des Umweltbundesamtes: Stoffmonographie für Glykolether, die zu Methoxyessigsäure verstoffwechselt werden – Referenz- und Human-Biomonitoring (HBM)-Werte für Methoxyessigsäure im Urin

2014

Bundesgesundheitsbl.

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Ethers of Ethylene Glycol and Derivatives

Kelsey

2023

Patty's Toxicology

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E series Glycol ethers are alkyl ethers of ethylene glycol along with their acetate esters. They are commonly used in paints and cleaners and typically have a higher boiling point in conjunction with the favorable solvent properties of lower‐molecular weight ethers, esters, and alcohols. They are colorless liquids that have mild earthy or fruity odors. The ethers are miscible with water and/or with numerous organic solvents making them useful as solvents in oil‐water compositions. Their relatively slow rate of evaporation also makes them useful as solvents and coalescing agents in paints and inks. The surface tension and solvent properties of the ethers make them useful in cleaners. Other uses of the ethers include process solvents and deicers. The ethers of the higher glycols are used as hydraulic fluids. Occupational exposure to glycol ethers occurs dermally and by inhalation. Most glycol ethers have low acute, single‐dose toxicity to humans. The most notable and well‐known effect relevant to humans is toxicity to male fertility and developmental toxicity produced by those glycol ethers that can metabolize to produce significant amounts of methoxyacetic acid such as methoxy ethanol and the methyl glymes.

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Industrial Contamination with Glycol Ethers Resulting in Teratogenic Damage

Cited by 12 publications

References 7 publications

Teratogenic Effect of Ethylene Glycol-Methyl Cellosolve Mixture in Rats: II. Craniofacial and Limb Abnormalities

Teratogenic Effect of Ethylene Glycol-Methyl Cellosolve Mixture in Rats: II. Craniofacial and Limb Abnormalities

Bekanntmachung des Umweltbundesamtes: Stoffmonographie für Glykolether, die zu Methoxyessigsäure verstoffwechselt werden – Referenz- und Human-Biomonitoring (HBM)-Werte für Methoxyessigsäure im Urin

Ethers of Ethylene Glycol and Derivatives

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