Industrial crystallization: Modeling of sucrose crystal growth

Borji, Abdelali; Borji, Fatima-Ezzahra; Jourani, A.

doi:10.1016/j.matpr.2020.11.577

Cited by 3 publications

(4 citation statements)

References 10 publications

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“…[3] When tracking objects, one of the challenges is to alter the object representation depending on the scene's context to consider changes in lighting, coloring, scaling, and other factors. [4]…”

Section: A Object Trackingmentioning

confidence: 99%

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Techy Tennis–A Game Beyond Reality

Zaveri¹,

Faisal²,

Imtiaz³

et al. 2023

JISR-C

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The concept is to create a game based on augmented reality and use object tracking as the primary function for recognizing objects using a camera. The key goal is to design an atmosphere that not only satisfies a person's desire to play video games but also lowers their stress levels in a manner that is both cost-effective and makes less use of flashy devices and cutting-edge technology. The environment produced in this way will use a camera that can identify objects and carry out a series of activities that have been preset according to their functions.

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Section: A Object Trackingmentioning

confidence: 99%

“…Figure. 4 gives a comprehensive depiction of the sequence of events for Techy Tennis. Techy tennis provides augmented reality and works using object tracking by recognizing with the help of a camera.…”

Section: Algoritthmmentioning

confidence: 99%

Techy Tennis–A Game Beyond Reality

Zaveri¹,

Faisal²,

Imtiaz³

et al. 2023

JISR-C

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“…(1) The characterization of APIs by advanced equipment proved that the introduction of excipients led to a decrease of crystal growth rate. 17 of polyvinyl pyrrolidone (PVP), hydroxypropyl methyl cellulose (HPMC), and hydroxypropyl methylcellulose acetate succinate (HPMCAS). 20 (2) The microscopic interaction between polymer and APIs can be analyzed by computational chemistry.…”

Section: Introductionmentioning

confidence: 99%

“…At present, the research of excipients on inhibiting API crystallization mainly focuses on the following three aspects. (1) The characterization of APIs by advanced equipment proved that the introduction of excipients led to a decrease of crystal growth rate. − Combining the characterization of differential scanning calorimetry (DSC) and polarized light microscopy with Raman microscopy, Tian et al found that the effectiveness of the polymers on inhibiting crystal growth of indomethacin, at a lower temperature, decreased in the order of polyvinyl pyrrolidone (PVP), hydroxypropyl methyl cellulose (HPMC), and hydroxypropyl methylcellulose acetate succinate (HPMCAS) . (2) The microscopic interaction between polymer and APIs can be analyzed by computational chemistry.…”

Section: Introductionmentioning

confidence: 99%

Influence Mechanism of Polymeric Excipients on Drug Crystallization: Experimental Investigation and Chemical Potential Gradient Model Analysis and Prediction

Qiao

Weng

Sadowski

et al. 2023

Crystal Growth & Design

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In this work, the influence of temperature, stirring speed, and polymeric excipients on crystal growth kinetics of active pharmaceutical ingredients (APIs) mesalazine and allopurinol was systematically investigated through experimental measurement and chemical potential gradient model. The results indicated that the two-step chemical potential gradient model showed good performance in modeling API crystal growth kinetics within the average relative deviations (ARDs) of 5%. Excipients (poly(ethylene glycol) (PEG), hydroxypropyl methyl cellulose (HPMC), and poly(vinyl pyrrolidone) (PVP)) played a crucial role in inhibiting the API crystal growth in all of the investigated systems. On one hand, excipients improved the API solubility, and on the other hand, the crystal growth rate of APIs was reduced remarkably by excipients. By comparing the diffusion rate constant (k d ) and the surface reaction rate constant (k s ) within the two-step chemical potential gradient model, it was found that the controlling step of mesalazine and allopurinol crystal growth was the surface reaction. Because of the presence of excipients, the diffusion rate constant was markedly decreased and the surface reaction order increased. Excipients hinder the surface reaction and decrease the crystal growth rate. Meanwhile, the crystal growth kinetics of mesalazine and allopurinol were predicted successfully with the ARDs of 2.5 and 6.5% under a certain temperature and stirring speed by the two-step chemical potential gradient model. This work provided a mechanistic understanding of how polymers inhibit API crystal growth.

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Fractionation of Bulk Food Products

Slavyanskiy

Mitroshina

Gribkova

et al. 2022

Food Processing: Techniques and Technology

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Powders are part of many food products, which makes grinding an important food industry process. The research objective was to develop a new process of separating a polydisperse powder that differs in particle density from the liquid it is dissolved in. The study featured polydisperse sugar powder crushed in a ball mill and dissolved in sugar wafer suspension. The article introduces a physical and mathematical model of the process and a method for quantitative modeling of the process of separating particles from powder by centrifuging the suspension. The research was based on the classical concept of the diameter of a particle moving in a predetermined manner in the inter-barrel space of the separator drum. The authors developed a new concept of the current critical particle diameter, which they calculated from the dispersion composition of the powder synthetic indicators, the control parameter of the suspension separation process, and the performance of the separating machine, e.g. coefficients of clarification and loss factor. The study resulted in a new calculation method with fewer fractionation stages. The authors calculated the separation of targeted particles from a granulometric composition by centrifuging the powder. The calculation method fits any fine and medium-dispersed particle size and can facilitate any quantitative analysis of fractionation processes in a disc separator.

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Industrial crystallization: Modeling of sucrose crystal growth

Cited by 3 publications

References 10 publications

Techy Tennis–A Game Beyond Reality

Techy Tennis–A Game Beyond Reality

Influence Mechanism of Polymeric Excipients on Drug Crystallization: Experimental Investigation and Chemical Potential Gradient Model Analysis and Prediction

Fractionation of Bulk Food Products

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