As the world moves deeper into the fourth industrial revolution, organizations around the world are polarizing towards the transformation and adoption of the advanced technologies of Industry 4.0. However, recent studies suggest that organizations struggle and face several managerial challenges in their implementation. As a consequence, many studies examined the potential factors that can influence Industry 4.0 implementation. Based on a systematic literature review, this study has tried to explore, examine, and synthesize the potential human resource (HR) success factors and develop an efficient Industry 4.0 HR framework that can play a vital role in Industry 4.0 implementation. This study would also build a solid foundation for practitioners, academicians, and researchers to get a better understanding of the impact of Industry 4.0 on HR management.