Indwelling Pleural Catheters Reduce Inpatient Days Over Pleurodesis for Malignant Pleural Effusion

Management of Pleural Effusion by Combining Talc Poudrage and Indwelling Pleural Catheter: A Retrospective Single Center Study

“…Nonetheless, according to the TIME2 trial this does not affect the quality of life in these patients [7]. The probability of spontaneous pleurodesis with an IPC insertion without additional talc poudrage lies between 26% and 76% [6,8,13]. The goal of regular drainage of IPC is symptom relief and promoting spontaneous pleurodesis by keeping the intrapleural space dry [6].…”

“…The use of IPCs improves the quality of life in patients [7]. The insertion of an IPC can reduce the hospitalization time in case of malignant pleural effusion since they can be inserted as an outpatient procedure [8].…”

Managing malignant pleural effusion with an indwelling pleural catheter: factors associated with spontaneous pleurodesis

“…Previous studies suggest that up to 20.6% (range, 1.6-20.6%) of IPCs need to be removed due to complications. [9][10][11]14,15,21,22 Nonetheless, serious complications are uncommon; the most common being pleural infection (0-16.7%). 23 The TIME2 study reported that the risk of pleural infection was 13.4% in the IPC group compared with 1.9% in the talc slurry pleurodesis group.…”

“…9 Another prospective open-label trial that compared IPC with talc slurry pleurodesis as first-line treatment for MPE also demonstrated that first-line use of IPC conferred non-inferior improvement in dyspnoea and quality of life, reduced effusion-related hospital stay by 7 to 11 days, and required less subsequent pleural procedures compared with talc slurry pleurodesis. 10 Research has shown that IPC is a safe procedure, with no complications in 87.5% (range, 54.5-100%) of patients. 11 Although the IPC is designed to be left permanently in situ in the pleural cavity in patients with advanced cancer, one unique advantage of IPC is the occurrence of autopleurodesis or spontaneous pleurodesis (SP)-ie pleurodesis achieved following IPC insertion without the use of sclerosant.…”

Efficacy of drainage of pleural effusion using small bore pleural catheter and conventional thoracostomy using large bore chest tube: a comparative study

“…In a comparative multicentre prospective study by Fysh et al, 10 patients with malignant pleural effusion were treated with Indwelling Pleural Catheter (IPC) or talc pleurodesis, based on patient choice. Key end points were hospital bed days from procedure to death (total and effusion-related).…”