A detailed study of the anharmonicity-induced resonances caused by the coupling of center-ofmass and relative motion is presented for a system of two ultracold atoms in single-well potentials. As has been confirmed experimentally, these inelastic confinement-induced resonances are of interest, since they can lead to coherent molecule formation, losses, and heating in ultracold atomic gases. A perturbative model is introduced to describe the resonance positions and the coupling strengths. The validity of the model and the behavior of the resonances for different confinement geometries are analyzed in comparison with exact numerical ab initio calculations. While such resonances have so far only been detected for large positive values of the s-wave scattering length, it is found that they are present also for negative s-wave scattering lengths, i. e. for attractive interactions. The possibility to coherently tune the resonances by a variation of the external confinement geometry might pave the way for coherent molecule association where magnetic Feshbach resonances are inaccessible.