Inertial focusing and passive micro-mixing techniques for rare cells capturing microfluidic platform

Phadke, Manisha; Shaner, Sebastian; Shah, Shreyas; Rodriguez, Ygnacio; Wibowo, Denni; Whulanza, Yudan; Teriete, Peter; Allen, J.W.; Kassegne, Sam

doi:10.1063/1.5023971

Cited by 6 publications

(2 citation statements)

References 11 publications

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“…A recent development in microfabrication has allowed us to manufacture a lab-on-a-chip (LoC) module to accommodate PCR process in a single microfluidic chip 19,20) . The LoC provides the filtering, the mixing, liquid handling, and heating of the specimen and reagents [21][22][23][24][25] . This allows us to decrease the expected consuming time for the process of PCR.…”

Section: Introductionmentioning

confidence: 99%

Heating Characterization of Low Energy Consumption Lab-on-a-Chip

Irwansyah¹,

Juana²,

Whulanza³

et al. 2021

Evergreen

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The ultimate goal of this study is to develop an effective and user-friendly form of thermal cycler to perform Polymerase Chain Reaction (PCR). This paper research the ability to manufacture a thermal cycler using conventional methods and readily available components to achieve a significant performance result with low production cost compared with commercially available counterparts. Commonly, thermal cyclers use an aluminum heating block as a heating vessel for samples, to achieve fast temperature changes and uniformity, but Polydimethylsiloxanes (PDMS) lab-on-a-chip (LoC) is utilized in contrast to silver as a heating vessel in this study to achieve biocompatibility with various samples. The raspberry-Pi pocket computer was used to achieve the necessary control with room for future capabilities addition and improvement. Characterization of the heating and PCR processes was done to understand the heat transfer phenomenon and thermal cycling speed in PDMS environment. This paper also includes analysis of the cycle speed corresponding to the control parameters of the manufactured thermal cycler. Ultimately, the characterization and analysis results will show the achieved performance capabilities of the thermal cycler.

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Section: Introductionmentioning

confidence: 99%

Heating Characterization of Low Energy Consumption Lab-on-a-Chip

Irwansyah¹,

Juana²,

Whulanza³

et al. 2021

Evergreen

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“…Microfluidic system are fabricated by etching or molding glass, silicone, acrylics, or other polymer types (Romao et al, 2017;Economou et al, 2018). In general, the polymer material is easily produced and performs well (Whulanza et al, 2017a(Whulanza et al, , 2018a(Whulanza et al, , 2019Phadke et al, 2018;Renatan et al, 2020). However, paper-based lab-on-a-chip (LOC) is the latest innovation, with the advantage of a low fabrication cost (Martinez et al, 2010;Ballerini et al, 2012;Costa et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Testing of Beeswax Printing Technology in the Design of a Paper-Based Microfluidic System

Nunut

Whulanza²,

Kassegne

2020

IJTech

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The development of additive manufacturing technologies has the advantage of producing more economical and efficient products. This trend is supported by the fact that this technology is extensively developed, so that it has easy platforms to use, vast applications, and is more economically affordable than it was when it was first created in the early 90s. Currently, this technology is also widely applied in the bioengineering field to produce so called micro-scale products. In this study, a beeswax printer was developed by modifying a universal 3D printer to apply beeswax as a microchannel part on paper. Ultimately, this application shall be used for paper lab-on-a-chip (LOC) that enables us to perform specific functions, such as biological detection. However, a thorough study is needed to understand the limitations of this beeswax printer, along with the characterization of its product. Here, an experiment was conducted to find the optimum conditions of the system with two main parameters, namely the heating characteristics and flowability of the molten beeswax during the printing process. Additionally, an analytical model was also developed to validate the phenomena of this advanced printing media. Briefly, the beeswax printer allowed us to have a fine profile in the range of 0.5-2.0 mm wide and 30-150 µm thick. This research allowed us to find the desired profile of printed beeswax.

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An overview on state-of-art of micromixer designs, characteristics and applications

Wang

Cai

et al. 2023

Analytica Chimica Acta

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Inertial focusing and passive micro-mixing techniques for rare cells capturing microfluidic platform

Cited by 6 publications

References 11 publications

Heating Characterization of Low Energy Consumption Lab-on-a-Chip

Heating Characterization of Low Energy Consumption Lab-on-a-Chip

Testing of Beeswax Printing Technology in the Design of a Paper-Based Microfluidic System

An overview on state-of-art of micromixer designs, characteristics and applications

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