Infant lower extremity long bone growth rates: comparison of contemporary with early 20th century data using mixed effect models

Tsai, Andy; Stamoulis, Catherine; Barber, Ignasi; Kleinman, Paul K.

doi:10.1002/ajhb.22905

Cited by 9 publications

(7 citation statements)

References 53 publications

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“…In contrast, pedicles demonstrate relatively constant growth rate. The average growth rate of a pedicle is 0.4 mm/day [26], similar to that of human femur (0.32 mm/day during embryonic development [34] and 0.42 mm/year from three to sixteen years of age [35,36] on average). Along with the fast growth of the antler, the coordinated regeneration of multiple tissue types such as blood vessels, nerves and the covering skin also grow rapidly.…”

Section: Introductionsupporting

confidence: 56%

Constructing the in vitro culture system of the sika deer (cervus nippon) antler periosteal cell to detect its function on antler regeneration

Wei¹,

Qin²,

Li³

et al. 2022

Front. Biosci. (Landmark Ed)

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Periosteum is essential for bone regeneration and damage repair in mammals. Most species of deer family (Cervidae) develop two kinds of special periosteum, antler periosteum and pedicle periosteum, both supporting the complete regeneration of antler. Antler is the bone organ with the fastest growth rate in mammals. Along with the fast growth of antler, its external tissues such as blood vessels, nerves and the covering skin also grow rapidly. Currently, it is still unclear whether antler periosteum contributes to the fast growth of antler and how. It is also unclear why the regenerative capacity of antler periosteum is weaker than that of pedicle periosteum. In this study, the in vitro culture system for antler periosteal cells (AnPC) was constructed for the first time using the mid-beam antler periostea during antler fast-growth period. According to our results, the cultured AnPC expressed classical MSC markers, consistent with the pedicle periosteal stem cells (PPSC). However, the fluorescence intensities of the MSC markers on AnPC were significantly weaker than those on PPSC. In addition, AnPC showed much lower proliferation rates than PPSC. The proliferation rates of the AnPC also gradually decreased after successive passages, while the proliferation rates of the pedicle periosteal stem cells remained unchanged. These findings may partially explain the weaker regenerative capacity of antler periosteum. Further comparative global gene analysis revealed clearly the different gene expressed patterns between AnPC and PPSC. AnPC may mainly function on promoting angiogenesis, nerve growth and intramembrane bone formation during antler regeneration, whereas PPSC may primarily be involved in androgen signaling receptor pathway and PI3K-Akt signaling pathway and function on maintaining stem cell renewal.

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Section: Introductionsupporting

confidence: 56%

Constructing the in vitro culture system of the sika deer (cervus nippon) antler periosteal cell to detect its function on antler regeneration

Wei¹,

Qin²,

Li³

et al. 2022

Front. Biosci. (Landmark Ed)

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“…1). 20 Physis width (red) was measured as the distance between the 2 widest points of the metaphysis. Tibial length (green) was measured from the inferior aspect of the proximal tibial physis to the superior aspect of the distal tibial physis in the midpoint of the tibia physis red line.…”

Section: Measurement Of Length Of Human Tibiaementioning

confidence: 99%

“…Long bone growth has been studied to provide the baseline and guideline for diagnosis and prognosis of bone growth disorders. 20,26,27 However, there are few reports to compare the growth plate morphometric value with bone length. We performed cross-sectional data analysis of the radiographic images and compared the height and width of growth plate of the proximal tibia with the length of the tibia, ranging from 0 to 12 years old in females, from 0 to 15 years old in males.…”

Section: Analysis Of Height and Width Of Human Growth Platementioning

confidence: 99%

Analysis of Association between Morphometric Parameters of Growth Plate and Bone Growth of Tibia in Mice and Humans

et al. 2020

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Objective The purposes of this study are to evaluate which growth plate parameters are associated with bone growth in mice and to compare the mouse results with those in humans. Design The sagittal sections of the proximal growth plate of the mouse tibia from neonate to young adult stages were subjected to histomorphometric and functional analyses. The radiographic images of tibias of human patients until puberty were analyzed to obtain the tibia length and the proximal growth plate height. It was found that a linear correlation best modeled the relationship between the growth plate variables with the tibia growth rate and length. Results In mice, total height, resting zone height, combined height of the proliferation and prehypertrophic zones, proliferation activity, and the total width of tibia growth plate showed high linear correlation with tibia bone length and bone growth rate, but the hypertrophic zone height and the growth plate area did not. In both mice and humans, the total growth plate width of tibia was found to have the strongest correlation with tibia length and growth rate. Conclusions The results validated that growth plate total height, the height of the resting zone and cell proliferation activity are appropriate parameters to evaluate the balance between growth plate activity and bone growth in mice, consistent with previous reports. The study also provided a new growth plate parameter candidate, growth plate width for growth plate activity evaluation in both mouse and human tibia bone.

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“…that observed in healthy children (Tsai et al, 2017). This growth impairment in the lower limbs contributed to the decreased height growth during the neonatal and infantile periods (Del Pino et al, 2018;Fong et al, 2001).…”

Section: Resultsmentioning

confidence: 81%

Radiological characteristics of skeletal growth in neonates and infants with achondroplasia

Miyahara,

Hasegawa,

Ago

et al. 2023

American J of Med Genetics Pt A

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Achondroplasia (ACH) is the most common form of skeletal dysplasia characterized by a rhizomelic short stature. Radiological skeletal findings in pediatric and adult patients with ACH include short long bones, a relatively longer fibula compared to the tibia, a narrow lumbar interpedicular distance, and a hypoplastic iliac wing. Nonetheless, the characteristics of skeletal growth during the neonatal and infantile periods have scarcely been explored. Therefore, this retrospective study aimed to analyze the radiological skeletal growth during the neonatal and infantile periods in 41 Japanese patients with genetically confirmed ACH. The length of long bones in the upper and lower limbs and the lumbar interpedicular distances at L1 and L4 were measured. These parameters showed significant positive correlations with age. The upper segment‐to‐lower segment ratio in the lower limbs resembled the data of healthy controls from previous reports. The L1/L4 and fibula/tibia ratios increased with age, suggesting that some representative skeletal phenotypes of ACH were less distinct during the neonatal and infantile periods. In conclusion, for the first time, this study radiologically characterized skeletal growth during the neonatal and infantile periods of patients with genetically confirmed ACH.

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Infant lower extremity long bone growth rates: comparison of contemporary with early 20th century data using mixed effect models

Abstract: This study provides reference standards for long bone growth rates during the dynamic period of infancy that may aid clinical assessment, and also inform research studies of disorders associated with altered skeletal growth.

Cited by 9 publications

References 53 publications

Constructing the in vitro culture system of the sika deer (cervus nippon) antler periosteal cell to detect its function on antler regeneration

Constructing the in vitro culture system of the sika deer (cervus nippon) antler periosteal cell to detect its function on antler regeneration

Analysis of Association between Morphometric Parameters of Growth Plate and Bone Growth of Tibia in Mice and Humans

Radiological characteristics of skeletal growth in neonates and infants with achondroplasia

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