Infant total diet study in France: Exposure to substances migrating from food contact materials

Sirot, Véronique; Rivière, Gilles; Leconte, Stéphane; Leblanc, Jean‐Charles; Kolf‐Clauw, Martine; Vasseur, Paule; Cravedi, Jean‐Pierre; Hulin, Marion

doi:10.1016/j.envint.2021.106393

Cited by 21 publications

(9 citation statements)

References 45 publications

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“…The phthalate concentrations in foods were within acceptable levels (0.118 mg/kg for DEP, 0.102 mg/kg for DEHP), and the dietary exposures to DEHP (0.395 μg/kg body weight/day), DEP (0.458 μg/kg body weight/day), and DiBP (0.0864 μg/kg body weight/day) were below the TDI. A total diet study (TDS) was conducted in France by Sirot et al [ 56 ] to evaluate the health risks of infants under three years of age related to the chemicals in food. Phthalates in food from food contact materials and other substances, such as bisphenol A (BPA), bisphenol A diglycidyl ether (BADGE), its derivatives, and some ink photoinitiators, were examined.…”

Section: Phthalatesmentioning

confidence: 99%

“…The upper-bound daily intakes of BPs for infants 0–6 months old were found to be between 0.044 and 1.29 μg/kg body weight/day. A comparison between breast and non-breastfed children was made in one study conducted in France [ 56 ]. The exposure levels, in some cases, exceeded the reference value established by the French Agency for Food, Environmental and Occupational Health & Safety (0.083 μg/kg body weight/day).…”

Section: Bisphenolsmentioning

confidence: 99%

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Endocrine-Disrupting Chemicals and Persistent Organic Pollutants in Infant Formulas and Baby Food: Legislation and Risk Assessments

Hatzidaki

Pagkalou

Katsikantami

et al. 2023

Foods

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Human milk is the healthiest option for newborns, although, under specific circumstances, infant formula is a precious alternative for feeding the baby. Except for the nutritional content, infant formulas and baby food must be pollutant-free. Thus, their composition is controlled by continuous monitoring and regulated by establishing upper limits and guideline values for safe exposure. Legislation differs worldwide, although there are standard policies and strategies for protecting vulnerable infants. This work presents current regulations and directives for restricting endocrine-disrupting chemicals and persistent organic pollutants in infant formulas. Risk assessment studies, which are limited, are necessary to depict exposure variations and assess the health risks for infants from dietary exposure to pollutants.

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Section: Phthalatesmentioning

confidence: 99%

Section: Bisphenolsmentioning

confidence: 99%

Endocrine-Disrupting Chemicals and Persistent Organic Pollutants in Infant Formulas and Baby Food: Legislation and Risk Assessments

Hatzidaki

Pagkalou

Katsikantami

et al. 2023

Foods

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“…As a follow up to the French Total Diet Study (TDS), ANSES launched a new TDS study targeting the population of infants and young children (0-3 years of age) in the infant Total Diet Study (iTDS) (Sirot, Rivière et al 2021). This time substances also coming from food contact materials were included in the study because of growing interest in these substances.…”

Section: Exposure Datamentioning

confidence: 99%

Roadmap for action on Risk Assessment of Combined Exposure to Multiple Chemicals (RACEMiC)

Jong

Voet

Marx‐Stoelting

et al. 2022

EFS3

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EFSA's aim by 2030, is that the Agency and its partners will be equipped for the routine implementation of human health risk assessment to multiple chemicals, across EFSA's domains of activity. To facilitate this effort, a roadmap for action has been developed by mapping the methods, data and tools that are currently available for mixture risk assessment and identifying current scientific gaps including challenges and blockers. The results shows that extensive methods, data and tools are available for dietary mixture risk assessment for pesticides, but that several scientific gaps still exist for the non‐dietary mixture exposure to pesticides. For food additives and for certain contaminants, the regulatory readiness for mixture risk assessment was also found to be fairly high compared to food contact materials and cross‐silo mixture risk assessment. The scientific gaps identified were prioritised according to their impact on the implementation of mixture risk assessment and, as a result, ten multi‐annual project proposals were defined to address these scientific gaps on the short‐term, mid‐term and long‐term. The roadmap also proposes and prioritises a number of working areas in the regulatory domains of pesticides, food contact materials, contaminants, food additives, as well as in the overarching domain of chemicals. Besides the scientific proposals, recommendations to improve stakeholder engagement and communication on mixture risk assessment was investigated. These included, among others, creating an online catalogue of tools, methods and data for mixture risk assessment, as well as the organisation of regular webinars/workshop to promote exchange of information between stakeholders and making more efficient use of national communication hubs for food safety in communicating with the general public.

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“…Bisphenol A diglycidyl ether (2,2-bis (4-glycidyloxyphenyl)propane, BADGE) is an industrial chemical and an important monomer of epoxy resin, which is the condensation product of bisphenol A (BPA) and epichlorohydrin. − It is widely used as a coating material of packages, such as food contact materials, agricultural spray coatings, anticorrosive coating, and so forth. Because of the complexity of the food matrix, hydrolysis or chlorination reaction can occur forming a variety of derivatives such as bisphenol A (2,3-dihydroxypropyl) glycidyl ether (BADGE·H 2 O), bisphenol A (3-chloro-2-hydroxypropyl) glycidyl ether (BADGE·HCl), and bisphenol A (3-chloro-2-hydroxypropyl)(2,3-dihydroxypropyl)glycidyl ether (BADGE·HCl·H 2 O) in the process of storage. − In fact, BADGE and its derivative residues had been detected in packaged foods such as canned seafood, canned meat products, canned vegetables, milk, and energy drinks from markets. − BADGE and its derivatives can affect the regulation of the human endocrine system through food chain enrichment, which is also called an exogenous endocrine disruptor.…”

Section: Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Development of ic-ELISAs for the Detection of Bisphenol A Diglycidyl Ether and Its Derivatives in Canned Luncheon Meats

Zhang

Song

et al. 2021

ACS Food Sci. Technol.

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Canned foods are widely consumed because of their convenience, hygiene, and nutrition. Bisphenol A diglycidyl ether (BADGE), an industrial product of epichlorohydrin and bisphenol A, widely exists in the inner coating of canned foods. A hydrolysis or chlorination reaction of BADGE can occur in the process of storage, forming a variety of derivatives such as bisphenol A (2,3dihydroxypropyl) glycidyl ether (BADGE•H 2 O), bisphenol A (3-chloro-2-hydroxypropyl) glycidyl ether (BADGE•HCl), and bisphenol A (3-chloro-2-hydroxypropyl) (2,3-dihydroxypropyl) glycidyl ether (BADGE•HCl•H 2 O), which seriously threaten consumer's health. In this research, two haptens were successfully synthesized, and antibodies were obtained by the subcutaneous immunization of New Zealand rabbits. Indirect competitive enzyme-linked immunosorbent assays (ic-ELISAs) were established for the detection of BADGE, BADGE•H 2 O, BADGE•HCl, and BADGE•HCl•H 2 O, and the IC 15 values (concentrations at an inhibition rate of 15%) were determined as 0.73, 0.39, 0.78, and 1.45 ng/mL, respectively. The recovery of BADGE and its derivatives at various spiking levels in canned luncheon meat samples ranged from 76.70 to 98.35%. The results detected by the proposed ic-ELISAs were also validated by HPLC analysis, which showed a good agreement (R 2 = 0.9861).

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Infant total diet study in France: Exposure to substances migrating from food contact materials

Cited by 21 publications

References 45 publications

Endocrine-Disrupting Chemicals and Persistent Organic Pollutants in Infant Formulas and Baby Food: Legislation and Risk Assessments

Endocrine-Disrupting Chemicals and Persistent Organic Pollutants in Infant Formulas and Baby Food: Legislation and Risk Assessments

Roadmap for action on Risk Assessment of Combined Exposure to Multiple Chemicals (RACEMiC)

Development of ic-ELISAs for the Detection of Bisphenol A Diglycidyl Ether and Its Derivatives in Canned Luncheon Meats

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