Infantile Colic: Crying Time Reduction With a Whey Hydrolysate: A Double-Blind, Randomized, Placebo-Controlled Trial

Lucassen, Peter; Assendelft, W.J.J.; Gubbels, J. W.; Eijk, J.T. van; Douwes, A. C.

doi:10.1542/peds.106.6.1349

Cited by 138 publications

(80 citation statements)

References 27 publications

(15 reference statements)

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“…Our findings show that infants fed with a partially hydrolysed formula, added with a mixture comprising 90% GOS and 10% FOS, had a significant decrease in colic episodes after 1 week of treatment compared to infants from the control group, confirming data of a previous observational study (Savino et al, 2003) and according to most of the diet studies on infantile colic (Lucassen et al, 1998(Lucassen et al, , 2000Garrison and Christakis, 2000). The difference in crying time was even more significant after 2 weeks of treatment.…”

Section: Discussionsupporting

confidence: 89%

“…allergy to cow's milk protein), but the strength of the relationship is not well defined (Hill and Hosking, 2000;Kalliomäki et al, 2001;Sicherer, 2003). Hypoallergenic formulas and mainly extensively hydrolysed formulas are effective in the treatment of infantile colic, indicating that dietary factors can play an important role (Lindberg, 1999;Jakobsson et al, 2000;Lucassen et al, 2000). However, considering the favourable clinical course of infantile colic, the wide range of manifestations, the day to day variability of crying time and the fact that many but not all the affected infants have symptoms related to cow's milk allergy, the majority of the studies on dietary interventions, particularly in formula-fed infants, concluded that further research is necessary (Lucassen et al, 1998;Garrison and Christakis, 2000).…”

Section: Introductionmentioning

confidence: 99%

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Reduction of crying episodes owing to infantile colic: a randomized controlled study on the efficacy of a new infant formula

et al. 2006

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Objectives: The aim of this study was to evaluate the efficacy on crying episodes owing to infantile colic of a new infant formula containing partially hydrolysed whey proteins, prebiotic oligosaccharides (OS), with a high b-palmitic acid content. Design: Prospective randomized controlled study. Setting: Italy. Subjects: Two hundred and sixty-seven formula-fed infants, aged less than 4 months, with infantile colic, were randomized to receive either the new infant formula (study treatment (ST)) or a standard formula and simethicone (6 mg/kg twice a day) (control treatment (CT)). A questionnaire was given to parents to evaluate for 14 days the daily number of colic episodes and crying time. Results: Out of the 199 infants who completed the study, 96 were treated with the new formula and 103 were not treated. Infants receiving the new formula had a significant decrease in colic episodes after 1 week (2.4771.94 at day 7 vs 5.9971.84 at the study entry) compared to infants receiving the CT (3.7271.98 at day 7 vs 5.4171.88 at the study entry) (Po0.0001). Also at day 14, the crying episodes were significantly different between the two groups of infants (1.7671.60 in ST vs 3.3272.06 in CT) (Po0.0001). Conclusions: The use of a partially hydrolysed formula supplemented with fructo-and galacto-OS induces a reduction of crying episodes in infants with colic after 7 and 14 days when compared with a standard formula and simethicone.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Reduction of crying episodes owing to infantile colic: a randomized controlled study on the efficacy of a new infant formula

et al. 2006

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“…Infantile colic is generally considered a benign and self-resolving condition, 2 yet it poses a burden on the affected families and may even trigger violent behavior toward the child. 3 Causal hypotheses relate to a gastrointestinal or a neurodevelopmental origin, such as altered gut microflora, 4,5 altered gastrointestinal motility, 6 lactose intolerance, 7,8 or a disorder in behavior regulation mechanisms. 1,9 Some consider infantile colic as an outlier in the developmental variation.…”

Section: Discussionmentioning

confidence: 99%

Nicotine Replacement Therapy During Pregnancy and Infantile Colic in the Offspring

et al. 2012

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WHAT'S KNOWN ON THIS SUBJECT: Infantile colic affects almost 10% of all infants and is characterized by crying and fussing in an otherwise healthy and well-fed infant. Prenatal exposure to tobacco smoking is a risk factor, but it is unclear whether nicotine causes the association.WHAT THIS STUDY ADDS: Infants exposed to nicotine replacement therapy during pregnancy had elevated infantile colic risk of the same magnitude as infants exposed to tobacco smoking. Intrauterine exposure to nicotine may play a causal role in the pathogenesis of infantile colic. abstract OBJECTIVE: To investigate the associations between use of nicotine replacement therapy (NRT) and smoking during pregnancy and infantile colic in the offspring. METHODS:We used data from maternal interviews (from pregnancy and at 6 months post partum) from the Danish National Birth Cohort (1996)(1997)(1998)(1999)(2000)(2001)(2002). We included 63 128 live-born singletons with complete information on nicotine exposure during pregnancy and infantile colic symptoms as recorded at 6 months of age. RESULTS:A total of 46 660 infants (73.9%) were unexposed to nicotine during pregnancy; 207 (0.3%) were exposed to NRT, 15 016 (23.8%) were exposed to smoking, and 1245 (2.0%) to both. A total of 4974 (7.9%) infants fulfilled Wessel' s modified criteria for infantile colic. Prenatal nicotine exposure was associated with elevated risk for infantile colic in the offspring. Compared with the unexposed, NRT users had an adjusted odds ratio (OR) (95% confidence interval) of 1.6 (1.0-2.5; P = .03), smokers had OR = 1.3 (1.2-1.4), and women who both smoked and used NRT had OR = 1.6 (1.3-1.9). Partners' smoking was not associated with infantile colic after adjustment for maternal smoking. CONCLUSIONS:We corroborated the association between smoking and infantile colic after adjustment for several possible confounders in a large cohort study. Moreover, we found that infants exposed to NRT prenatally had an increased risk for infantile colic of the same magnitude as those exposed to tobacco smoke. Thus, nicotine may play a role in the pathogenesis of infantile colic. Pediatrics 2012;129:e652-e658 AUTHORS:

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“…Они реко-мендованы, если колики не сочетаются с клинически-ми проявлениями атопического дерматита, и к тому же имеют преимущества перед глубокими гидролизатами в отношении цены. Эффективность указанных смесей при детских коликах подтверждена в рандомизирован-ных контролируемых исследованиях [17,18]. Более того, в ряде случаев эти смеси содержат пребиотики или отно-сятся к низколактозным смесям, что также способствует снижению частоты эпизодов колик в неделю.…”

Section: кишечные коликиunclassified

Current Data on Gastro-Intestinal Dysfunctions in Children

Грибакин¹,

Гаранкина²,

Давыдовская³

2013

Vopr. sovr. pediatr.

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У детей первого года жизни нередко возникают функциональные нарушения пищеварения (срыгивания, запоры, кишечные колики, метеоризм), которые в ряде случаев становятся причиной обращения родителей к врачу-педиатру [1,2]. Это нередко приводит к замене одних детских молочных смесей на другие, поскольку среди родителей (и отчасти среди врачей) бытует мне-ние, что подобная симптоматика означает «неперено-симость детской молочной смеси». Однако показатели роста и развития детей в большинстве случаев остаются в пределах возрастной нормы. СРЫГИВАНИЯ (РЕГУРГИТАЦИЯ)Ежедневно возникающие срыгивания достига-ют частоты 86,9% у детей двухмесячного возраста, а к 1 году частота их снижается до 7,6% [3]. Наличие срыгиваний зависит от объема пищи: чем больше объем кормления, тем более продолжительна эва-куация пищи из желудка и выше внутрижелудочное давление, вследствие чего чаще возникает спонтан-ная реакция нижнего пищеводного сфинктера, кото-рая способствует появлению гастроэзофагального рефлюкса (ГЭР).

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Infantile Colic: Crying Time Reduction With a Whey Hydrolysate: A Double-Blind, Randomized, Placebo-Controlled Trial

Abstract: An extensively hydrolyzed whey formula is effective in reducing the duration of crying in a primary care setting.

Cited by 138 publications

References 27 publications

Reduction of crying episodes owing to infantile colic: a randomized controlled study on the efficacy of a new infant formula

Reduction of crying episodes owing to infantile colic: a randomized controlled study on the efficacy of a new infant formula

Nicotine Replacement Therapy During Pregnancy and Infantile Colic in the Offspring

Current Data on Gastro-Intestinal Dysfunctions in Children

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