Infantile Intravesical Malignant Rhabdoid Tumour

Abstract

Malignant rhabdoid tumour is a rare, but highly aggressive, malignancy of early childhood. Malignant rhabdoid tumour can be classified according to renal and extrarenal locations. For extrarenal lesions, the spinal cord and central nervous system are most commonly involved, although such tumours may arise in almost any site. However, malignant rhabdoid tumour of the bladder has only been reported in a few patients, mainly focusing on its pathological aspects. We report on a patient with malignant rhabdoid tumour of the urinary bladder. The clinical, radiological, and histological features of this disease entity are discussed.

Genetics of Bladder Malignant Tumors in Childhood

“…The treatment approach is different for rhabdoid tumour than for other bladder tumours, usually involving partial cystectomy and chemotherapy. The prognosis of children with malignant rhabdoid tumour is poor, therefore, making an early and accurate diagnosis is essential [ 128 ]. Genes important for MRT in childhood are illustrated in (Table 2 ).…”

“…Thus, a positive INI1 stain result will show loss of nuclear INI1 staining, as suggested in a case report and review. The cystectomy specimen of this patient exhibited loss of INI1 staining [ 128 ]. 98% of rhabdoid tumors demonstrate SMARCB1 loss and concomitant deletions or mutations of the SMARCB1 gene [ 130 ].…”

Extra-renal malignant rhabdoid tumor of head and neck region: Characteristics of tracer uptake on FDG PET/CT in tumor with rare histology

“…[ 3 ] As per the existing literature, ERRTs demonstrate intense FDG uptake at the primary and metastatic sites. [ 4 ] However, our case is an exception wherein the tumor shows very low-grade tracer concentration. Also, the pattern of uptake is quite uniform, and cannot be appreciated on Maximum Intensity Projection (MIP) images.…”

Malignant rhabdoid tumors of soft tissues in children. Literature review

“…Единого подхода в терапии рабдоидных опухолей нет и проанализировать преимущества отдельных режимов ПХТ невозможно из-за малого числа па-циентов, что также наглядно отражено в представ-ленных клинических случаях [53][54][55][56][57][58][59][60][61][62][63][64][65][66][67][68][69][70]. Показано, что на выживаемость влияет использование высоких доз алкилирующих агентов, в том числе антрациклино-вых антибиотиков и актиномицина D [9,80].…”