Infantile myofibromatosis—a review

Abstract

Infantile myofibromatosis is a rare condition which usually presents in childhood. It has a wide spectrum of disease activity, ranging from a solitary cutaneous nodule, through to a multicentric form with widespread visceral involvement. We present four cases which demonstrate the diversity of this condition and its radiological findings, together with a review of the literature.

Cure of infantile myofibromatosis with severe respiratory complications without antitumour therapy

“…Evaluating the ecacy of these regimens is dicult in a disease with tendency to spontaneous regression. It has been shown that in cases without visceral involvement considerable progression can occur before spontaneous regression starts [6,11]. This is true also for our case.…”

Mediastinal and pulmonary infantile myofibromatosis: an unusual surgical presentation

“…Invariably, the visceral IM is associated with superficial nodules, and therefore, the diagnosis can be achieved by the biopsy of the peripheral nodules. The multifocal visceral IM should be investigated for the bony lesions primarily by a skeletal survey, and additional imaging depends on the clinical indications [8]. In our case, clinically, radiologically, and histologically, only one lung and hilum was affected with IM, and therefore, the diagnosis was not possible without major intervention.…”

Unilateral breast mass in an infant: a rare presentation of spontaneously regressing myofibromatosis

“…Computed tomographic imaging features usually consist of hypodense tissue that shows some enhancement with contrast, and bone involvement often take the shape of circumscribed lytic lesions with sclerotic margins [12]. Magnetic resonance imaging of the tumor typically reveals low intensity in T1-weighted images and high intensity on T2 [8].…”

“…After confirming the diagnosis by obtaining a true-cut biopsy and identifying the disease extension by imaging, these lesions can be observed clinically. Excision is not warranted unless they are causing significant symptoms [8,12] because both multicentric nonvisceral and solitary tumors carry an excellent prognosis.…”