To make sense of others’ actions, we generally consider what information is available to them. This information may come from different sources, including perception and inference. Like adults, young infants track what information agents can obtain through perception: If an agent directly observes an event, for example, they expect her to have information about it. However, no investigation has yet examined whether young infants also track what information agents can obtain through inference, by bringing to bear relevant general knowledge. Building on the finding that by 4 months of age, most infants have acquired the physical rule that wide objects can fit into wide but not narrow containers, we asked whether 5-month-olds would expect an agent who was searching for a wide toy hidden in her absence to reach for a wide as opposed to a narrow box. Infants looked significantly longer when the agent selected the narrow box, suggesting that they expected her (a) to share the physical knowledge that wide objects can fit only into wide containers and (b) to infer that the wide toy must be hidden in the wide box. Three additional conditions supported this interpretation. Together, these results cast doubt on two-system accounts of early psychological reasoning, which claim that infants’ early-developing system is too inflexible and encapsulated to integrate inputs from other cognitive processes, such as physical reasoning. Instead, the results support one-system accounts and provide new evidence that young infants’ burgeoning psychological-reasoning system is qualitatively similar to that of older children and adults.