Infección de vías urinarias después de resección transuretral de vejiga: Microbiología, resistencia antibiótica y factores de riesgo asociados.

Abstract

Objective: Investigate the microbiology and incidence of drug resistance in patients undergoing TURBT and to identify independent risk factors for UTI following surgery.
 Material & Methods : Retrospective observational study of prospectively collected data of 199 patients who underwent TURBT in a tertiary care center in Mexico City between 2017-2019. Baseline characteristics and microbiological data (frequency of isolated bacteria and antibiotic resistance pattern) were analyzed according to the presence of UTI following surgery. Binary logistic regression analysis was performed to identify independent risk factors for UTI.
 Results: A preoperative positive urine culture (PUC) was present in 28 patients (14%), the most common isolated pathogens were Escherichia coli(48%), Enterococcus faecalis(24%) and Proteus mirabilis(7%). UTI was documented in 20 patients after TURBT (10%), being E. coli(45%) the most common uropathogen which was resistant to Trimethoprim/Sulfamethoxazole(60%) and Ciprofloxacin(40%). Other common isolated pathogens were E. faecalis(27%) and P. mirabilis(9%). There was significant difference in the presence of a PUC before TURBT and necrosis (p=0.001). On the multivariate analysis the PUC before TURBT was associated with UTI after TURBT (OR7.04 [95%CI 2.11-23.29]).
 Limitations: Retrospective study with information limited to the clinical file.
 Originality: There is little information about UTI after TURBT in global literature, in Mexico there is no information, being this study unique in his kind.
 Conclusions: The incidence of UTI after TURBT was 10%. The strongest associated risk factor for UTI after TURBT was a preoperative PUC. The most common isolated uropathogen was E. coli. Trimethoprim/Sulfamethoxazole(60%) and Ciprofloxacin(40%) were the most resistant antibiotics for E. coli.

Assessment of Beta-lactamases and Integrons Genes among Bacteria Isolated From Bladder Cancer Patients with Urinary Tract Infections

“…Our findings concur with those of ( 24), who reported that 73 (24%) of the 308 urine samples from cancer patients in Nebal that had been subjected to culture contained bacterial growth. (25) similarly in line with our findings, discovered that from approximately 199 bladder ca. patients in Mexico City, 20 patients (10%) had UTI following TURBT; 100 of the 497 processed samples from cancer patients in India who were thought to have UTIs tested positive for bacterial growth, according to (23); At Al-Diwaniya Teaching Hospital/Al-Diwaniya Governorate/Iraq, 33 urine samples from bladder Ca.…”