Infección por el virus de la hepatitis B en individuos con factores de exposición en Quibdó y Apartadó, Colombia

Patiño, David Ríos; V, Diana di Filippo; E, Margarita Insuasty; L, Julio C Rendón; O, Wilson Alfredo Ríos; L, Carlos Medina; Hoyos, María Cristina; G, Carlos Julio Montoya; N, María Cristina Navas

doi:10.22516/25007440.17

Cited by 7 publications

(2 citation statements)

References 17 publications

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“…The 36 municipalities assessed as most at risk of having ongoing HBV transmission were located across 16 of Colombia's 32 departments. Of those departments, 11 (Amazonas, Antioquia, Cesar, Chocó, Guainía, Guaviare, La Guajira, Magdalena, Nariño, Norte de Santander and Vaupes) had been previously documented to have moderate or high burden of hepatitis B 16,17,18,19,20,21 and five (Boyacá, Cundinamarca, Huila, Putumayo and Santander) had not. Figure 1 shows the municipalities included in the study.…”

Section: Resultsmentioning

confidence: 99%

Progress towards the elimination of hepatitis B in children in Colombia: A novel two‐phase study approach

Ríos-Hincapié

Murad-Rivera

Tohme

et al. 2022

Journal of Viral Hepatitis

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The World Health Organization (WHO) has established a target to eliminate mother‐to‐child‐transmission (EMTCT) of hepatitis B virus (HBV), defined as a prevalence of hepatitis B surface antigen (HBsAg) of ≤0.1% among children, by 2030. Using nationally representative serosurveys to verify achievement of this target requires large sample sizes and significant resources. We assessed the feasibility of a potentially more efficient two‐phase method to verify EMTCT of HBV in Colombia. In the first phase, we conducted a risk assessment to identify municipalities at the highest risk of ongoing HBV transmission. We ranked the 1122 municipalities of Colombia based on the reports of HBV infection in pregnant women per 1000 population. Municipalities with ≥0.3 reports per 1000 persons (equating to the top quartile) were further assessed based on health facility birth rates, coverage with three doses of hepatitis B vaccine (HepB3) and seroprevalence data. Hepatitis B risk was considered to be further increased for municipalities with HepB3 coverage or health facility birth rate <90%. In the second phase, we conducted a multistage household serosurvey of children aged 5–10 years in 36 municipalities with the highest assessed HBV risk. HBsAg was not detected in any of 3203 children tested, yielding a 90% upper confidence bound of <0.1% prevalence. Coverage with HepB3 and hepatitis B birth dose was high at 97.5% and 95.6%, respectively. These results support the conclusion that Colombia has likely achieved EMTCT of HBV.

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Section: Resultsmentioning

confidence: 99%

Progress towards the elimination of hepatitis B in children in Colombia: A novel two‐phase study approach

Ríos-Hincapié

Murad-Rivera

Tohme

et al. 2022

Journal of Viral Hepatitis

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“…Ten HBV genotypes (A–J), with a genetic diversity of more than 8%, and 40 subgenotypes with a genetic divergence of more than 4% have been described [ 5 ]. HBV genotypes F and A are the most prevalent reported in different populations in Colombia; although genotypes C, D, E and genotype G have been also described [ 6 , 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Epidemiology and Genetic Diversity of Hepatitis B Virus and Hepatitis Delta Virus Infection in Indigenous Communities in Colombia

et al. 2023

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Despite the universal vaccination program, there are still regions and territories with a high prevalence of Hepatitis B Virus infection (HBV), such as the Amazon basin, where several indigenous communities live. Additionally, Hepatitis Delta Virus (HDV) is a defective that requires the hepatitis B surface antigen (HBsAg) for the assembly and release of de novo viral particles. Therefore, hepatitis D could be the result of HBV/HDV coinfection or HDV superinfection in individuals with chronic hepatitis B. Among the high prevalence HDV populations are indigenous communities of America. This study aims to describe and characterize the frequency of HBV and HDV infection, viral genotypes and HBV immune escape mutants in indigenous populations from different regions of Colombia. The diagnosis of hepatitis B and hepatitis D was confirmed by serological markers. Moreover, the HBV and HDV genome were amplified by PCR and RT-PCR, respectively, and, subsequently, the phylogenetic analysis was performed. We characterized 47 cases of chronic hepatitis B, 1 case of reactivation and 2 cases of occult hepatitis B infection (OBI). Furthermore, a high prevalence of HDV infection was identified in the study population (29.33%, 22/75) and the circulation of several HBV genotypes and subgenotypes (F1b, F3, F4, and D). Interestingly, this is the first report of the HDV genotype I circulation in this country. These findings demonstrated that HBV and HDV infections are still public health problems in indigenous communities in Colombia.

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Hepatitis D virus and hepatitis B virus infection in Amerindian communities of the Amazonas state, Colombia

Villa

Cortés-Mancera

Payares

et al. 2015

Virol J

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BackgroundIn Colombia, cases of Hepatitis D virus (HDV) infection have been officially described since 1985 mainly in Amerindian population from Sierra Nevada de Santa Marta (North Caribbean Coast), Uraba (North West), and Amazon (South East). The last official report of a clinical case of HDV infection in Colombia was registered in 2005.ObjectivesThe aims of this study were to identify cases of HDV and/or Hepatitis B virus (HBV) infection in asymptomatic Amerindians from Amazonas state, South East Colombia, and to describe the circulating viral genotypes in this population.Study designThe study population was recruited in 19 Amerindian communities in the Amazonas state. Individuals over 18 years old were screened by rapid test for Hepatitis B surface Antigen (HBsAg). Blood samples obtained from individuals positives for HBsAg in the rapid-test assay were analyzed for HBsAg, anti-HBc, anti-HDV IgM/IgG by ELISA. The detection of HBV DNA and HDV RNA was performed by PCR amplification. The viral genotype was determined by sequencing and phylogenetic analysis.ResultsA total of 23/861 individuals were positive for HBsAg detection by rapid test. Serological and/or molecular markers of HDV infection were demonstrated in 43.5 % (10/23) of samples from Amerindians. The phylogenetic analysis demonstrated the exclusive circulation of HBV subgenotype F1b of and HDV 3 in this population.ConclusionsA high frequency of HBV/HDV infection was found in Amerindian population from Amazonas State, Colombia (43.5 %, 10/23). Nine cases were identified in a population of 861 asymptomatic Amerindian individuals; one symptomatic case (with diagnosis of end-stage hepatic disease) was also identified in the study. The circulation of HDV 3 and HBV subgenotype F1b suggests a constant flow of these viral genotypes as a result of the interaction of the Amerindian populations from Amazon basin. Further studies are necessary to confirm whether HBV subgenotype F1b is the prevalent in the population from South East region in Colombia.

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Infección por el virus de la hepatitis B en individuos con factores de exposición en Quibdó y Apartadó, Colombia

Cited by 7 publications

References 17 publications

Progress towards the elimination of hepatitis B in children in Colombia: A novel two‐phase study approach

Progress towards the elimination of hepatitis B in children in Colombia: A novel two‐phase study approach

Epidemiology and Genetic Diversity of Hepatitis B Virus and Hepatitis Delta Virus Infection in Indigenous Communities in Colombia

Hepatitis D virus and hepatitis B virus infection in Amerindian communities of the Amazonas state, Colombia

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