Infección rinosinusal por Scedosporium apiospermum en un hospedero inmunocompetente

Abstract

Scedosporium apiospermum rhinosinusal infection in an immunocompetent hostScedosporium species can cause colonization, superficial and deep localized infection or systemic disease, especially in immunocompromised hosts. We report a case of localized infection due to Scedosporium apiospermum in a 47 year old woman, with previous nasal surgery. She consulted for recurrent mucopurulent post-nasal discharge not responding to antibiotics. Computed tomography showed opacification of right maxillary sinus. Surgery was performed to removed abnormal tissue from sinus; biopsy revealed chronic sinusitis with aggregate of tightly packed hyphae suggestive of filamentous fungi. The microbiology fungal culture reported Scedosporium apiospermum.

Routine screening of harmful microorganisms in beach sands: Implications to public health

“…Most of these cases have involved patients who are immunocompromised, and thus, relatively more vulnerable to infection by opportunistic pathogens. But, some cases have involved patients who are immunocompetent (Chanqueo et al, 2009). Indeed, species of the opportunistic fungi Scedosporium have become increasingly recognized as an emerging pathogen among the ever-increasing population of immunocompromised individuals.…”

Frequency of fungal agents identified in sinus samples from patients with clinically suspected rhinosinusitis

“…The immune status of the patient plays an important role in the development of this fungal disease, immunocompromised patients mainly showing aggressive infections; by contrast, immunocompetent individuals tend to present benign disease, manifested as colonizations or fungal balls (Chanqueo et al, 2009). Unfortunately, one of the limitations of the present study was that the information related to the immune status of patients in the database provided was limited and, in some cases, absent.…”

“…Other studies have reported that 10-13% of patients suffering CRS are infected by fungi and 13-28% had the maxillary sinus compromised (Chanqueo et al, 2009), equivalent to 80% of cases of FRS (Chanqueo et al, 2009;López-Vázquez et al, 2012;Maltrana et al, 2004;Vélez and Rosso-Suárez, 2012;Yánez-García et al, 2003). In the present study, it was observed that 24% of clinical samples that were positive for fungal infection/colonization involved the maxillary sinus.…”

“…Samples obtained from sinus in which localization was not specified. opportunistic pathogen, while Curvularia is the etiological agent most frequently described as the causative agent of allergic FRS or noninvasive FRS (Chanqueo et al, 2009). In this report, Curvularia spp.…”

“…The most frequent route of colonization of the sinus is via inhalation of spores (López-Vázquez et al, 2012;Vergara and Hernández, 2007) or by direct inoculation (Vergara and Hernández, 2007). The immunological status of patients is known to determine the development of diseases (Maltrana et al, 2004); thus, invasive forms of FRS are typical in immunocompromised patients (Davis and Kita, 2004;Maltrana et al, 2004;Vélez and Rosso-Suárez, 2012;, whereas noninvasive forms are the most common presentations in immunocompetent individuals (Chanqueo et al, 2009;Maltrana et al, 2004). In recent years, the growth in numbers of patients with some degree of immunodeficiency (transplants, immunosuppressive drugs, diabetes, HIV infection, and leukemias, etc) has resulted in an increase in the invasive forms of FRS (Maltrana et al, 2004).…”