Infected thoracic aortic aneurysm caused by Clostridium ramosum: A case report

Kozaki, Satoshi; Miyamoto, Shinj̀i; Uchida, Kaoru; Shuto, Takashi; Tanaka, Hideyuki; Wada, Tomoyuki; Anai, Hirofumi

doi:10.1016/j.jccase.2019.06.005

Cited by 8 publications

(11 citation statements)

References 7 publications

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“…To our best knowledge, no evidence-based guidelines have been proposed to date to support adequate antibiotic therapy for Erysipelatoclostridium ramosum infections. Published literature has mostly reported individual cases suggesting certain antibiotics for the treatment of these infections based on in vitro susceptibility testing 4 , 5 , 7 , 14 , 17 , 18 . E. ramosum shows excellent susceptibility to piperacillin-tazobactam, amoxicillin/clavulanate, ampicillin/sulbactam, imipenem, meropenem, metronidazole, vancomycin and chloramphenicol.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial treatment of Erysipelatoclostridium ramosum invasive infections: a systematic review

Milosavljević

Kostić

Milovanović

et al. 2021

Rev. Inst. Med. trop. S. Paulo

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The aim of this systematic review was to determine the causal role of Erysipelatoclostridium ramosum in specific invasive infections in humans, and to assess the clinical outcome of antibiotic therapy used to treat them. Several electronic databases were systematically searched for clinical trials, observational studies or individual cases on patients of any age and gender with a systemic inflammatory response syndrome (SIRS) due to E. ramosum isolated from body fluids or tissues in which it is not normally present. Only reports identifying E. ramosum as the only microorganism isolated from a patient with SIRS were included. This systematic review included 15 studies reporting 19 individual cases in which E. ramosum caused invasive infections in various tissues, mainly in immunocompromised patients. E. ramosum was most often isolated by blood cultures and identified by specific biochemical tests. Severe infections caused by E. ramosum were in most cases effectively treated with antibiotics, except in two patients, one of whom died. More than one isolate of E. ramosum exhibited 100% susceptibility to metronidazole, amoxicillin/clavulanate and piperacillin/tazobactam. On the other hand, individual resistance of this bacterium to penicillin, ciprofloxacin, clindamycin, imipenem and ertapenem was reported. This systematic review confirmed the clinical relevance of E. ramosum as a cause of a number of severe infections mainly in immunocompromised inpatients. Metronidazole and meropenem appear to be the antibiotics of choice that should be used in combination or as monotherapy to treat E. ramosum infections, depending on the type and severity of the infection.

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Section: Introductionmentioning

confidence: 99%

Antimicrobial treatment of Erysipelatoclostridium ramosum invasive infections: a systematic review

Milosavljević

Kostić

Milovanović

et al. 2021

Rev. Inst. Med. trop. S. Paulo

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“…7Left femoral artery emboli in a case of endocarditis [34]. 8Aortic wall and surrounding tissue in a case of infected thoracic aortic aneurysm [49]. 9Middle ear in two cases of acute otitis media [31,47].…”

Section: Case Presentationmentioning

confidence: 99%

“…(13) Synovial fluid and intraoperative samples in a case of knee prosthetic joint infection [39]. Interestingly, 11 of these 14 samples (78 %) yielded C. ramosum in pure culture [17,18,21,28,31,34,39,45,48,49].…”

Section: Case Presentationmentioning

confidence: 99%

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Clostridium ramosum rapidly identified by MALDI-TOF MS. A rare gram-variable agent of bacteraemia.

Legaria

García

Tudanca

et al. 2020

Access Microbiology

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Clostridium ramosum is an enteric anaerobic, endospore-forming, gram-positive rod with a low GC content that is rarely associated with disease in humans. We present a case of C. ramosum bacteraemia. To the best of our knowledge, this is the second case of C. ramosum bacteraemia in an elderly patient presenting with fever, abdominal pain and bilious emesis. We highlight the Gram stain variability, the lack of visualization of spores and the atypical morphology of the colonies that showed C. ramosum in a polymicrobial presentation that initially appeared to show monomicrobial bacteraemia. The microorganism was rapidly identified by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). We present a comprehensive literature review of 32 cases of clinical infections by C. ramosum in which we describe, if available, sex, age, clinical symptoms, predisposing conditions, other organisms present in the blood culture, other samples with C. ramosum, identification methodology, treatment and outcome.

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“…Infected AD is a rare life threatening condition because of the possibility of rupture as well as perforation to surrounding organs. Although less common, infective aortic disease due to bacteria (such as staphylococcus, salmonella, mycobacteria) and virus (such as Zoster Virus,) have been reported [7][8]. The infection related in ammatory response in the vascular media may lead to aortic dilation and formation of aneurysm [9].…”

Section: Introductionmentioning

confidence: 99%

Hemorrhagic fever with renal syndrome with concurrent aortic dissection: a case report

Qiu¹,

Li²,

Zhou³

2020

Preprint

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Background Hemorrhagic fever with renal syndrome (HFRS) is caused by hantaviruses presenting with high fever, hemorrhage, acute kidney injury. Microvascular injury and hemorrhage in mucus was often observed in patients with hantavirus infection. Infection with bacterial and virus related aortic aneurysm or dissection occurs sporadically. We present a previously unreported case of hemorrhagic fever with concurrent Stanford B aortic dissection. Case presentation: A 56-year-old man complained of high fever, generalized body ache, with decreased platelet counts of 10 × 10^9/L and acute kidney injury. The ELISA test for Hantaan virus of IgM and IgG antibodies were both positive. During the convalescent period, he complained sudden onset acute chest pain radiating to the back and the CTA revealed an aortic dissection of the descending aorta extending to iliac artery. He was diagnosed with Hemorrhagic fever with renal syndrome and Stanford B aortic dissection. The patient recovered completely after surgery with other support treatments. Conclusion We present a case of HFRS complicated with aortic dissection,and no study has reported the association of HFRS with aortic disease. However, we suppose that hantavirus infection not only cause microvascular damage but may be risk factor for acute macrovascular detriment. A causal relationship has yet to be confirmed.

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Infected thoracic aortic aneurysm caused by Clostridium ramosum: A case report

Cited by 8 publications

References 7 publications

Antimicrobial treatment of Erysipelatoclostridium ramosum invasive infections: a systematic review

Antimicrobial treatment of Erysipelatoclostridium ramosum invasive infections: a systematic review

Clostridium ramosum rapidly identified by MALDI-TOF MS. A rare gram-variable agent of bacteraemia.

Hemorrhagic fever with renal syndrome with concurrent aortic dissection: a case report

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