Antimicrobial treatment of Erysipelatoclostridium ramosum invasive infections: a systematic review

Abstract

The aim of this systematic review was to determine the causal role of Erysipelatoclostridium ramosum in specific invasive infections in humans, and to assess the clinical outcome of antibiotic therapy used to treat them. Several electronic databases were systematically searched for clinical trials, observational studies or individual cases on patients of any age and gender with a systemic inflammatory response syndrome (SIRS) due to E. ramosum isolated from body fluids or tissues in which it is not normally present. Only reports identifying E. ramosum as the only microorganism isolated from a patient with SIRS were included. This systematic review included 15 studies reporting 19 individual cases in which E. ramosum caused invasive infections in various tissues, mainly in immunocompromised patients. E. ramosum was most often isolated by blood cultures and identified by specific biochemical tests. Severe infections caused by E. ramosum were in most cases effectively treated with antibiotics, except in two patients, one of whom died. More than one isolate of E. ramosum exhibited 100% susceptibility to metronidazole, amoxicillin/clavulanate and piperacillin/tazobactam. On the other hand, individual resistance of this bacterium to penicillin, ciprofloxacin, clindamycin, imipenem and ertapenem was reported. This systematic review confirmed the clinical relevance of E. ramosum as a cause of a number of severe infections mainly in immunocompromised inpatients. Metronidazole and meropenem appear to be the antibiotics of choice that should be used in combination or as monotherapy to treat E. ramosum infections, depending on the type and severity of the infection.

Analysis of the gut microbiota composition of myostatin mutant cattle prepared using CRISPR/Cas9

“…In our study, we found that the abundance of Pseudoflavonifractor, a type 2 diabetes-related flora, was decreased in MT cattle, indicating that MSTN can regulate metabolism by regulating intestinal flora. Some flora associated with intestinal inflammation was increased in MT cattle, such as Erysipelatoclostridium [44], Prevotellaceae_Ga6A1_group [45], and Candidatus_Saccharimonas [46], whereas some flora associated with intestinal inflammation was decreased in MT cattle, such as Paraclostridium, Porphyromonas, Terrisporobacter, and Paeniclostridium. Therefore, in this study, the effect of MSTN mutation on intestinal inflammation could not be determined.…”

High-sugar, high-fat, and high-protein diets promote antibiotic resistance gene spreading in the mouse intestinal microbiota

“…In addition, some ARGs are directly distributed in pathogenic bacteria, such as Clostridium and Chlamydia , which can cause a variety of diseases, and Escherichia and Erysipelatoclostridium , which are common in severe infections. 53 Once the infection is rampant, it places a great burden on the host, and is difficult to treat due to the protective effects of ARGs. During clinical treatment, bacteremia patients infected with carbapenem-resistant Enterobacter-iaceae or carbapenem-resistant Pseudomonas aeruginosa suffer 40–70% mortality.…”

A microbiome study reveals the potential relationship between the bacterial diversity of a gymnastics hall and human health

“…In the AG hall (in red), the biomarker microorganism is Rhizobiales, while in the RG hall (in green), the biomarker microorganisms are Erysipelatoclostridium and Lachnospiraceae . E. ramosum , a species in the genus Erysipelatoclostridium , is a normal member of the human gut microbiota and only causes invasive infections in rare cases 27 . The members of Lachnospiraceae are the core taxa of the intestinal tract and have a high species abundance and relative abundance in the life cycle of the host.…”