Infection and chronic allograft dysfunction

Dupont, Peter; Manuel, Oriol; Pascual, Manuel

doi:10.1038/ki.2010.423

Cited by 26 publications

(21 citation statements)

References 106 publications

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“…Recurrent infection episodes were seen in only 4% of patients. Although there is consensus that recurrent UTIs have a potential for unfavorable renal allograft outcome, the association of VUR with UTIs is less certain (32). Previously published studies postulated VUR as a possible risk factor for developing recurrent UTIs (33).…”

Section: Discussionmentioning

confidence: 99%

Value of Routine Voiding Cystourethrography After Renal Transplantation

Margreiter

Györi

Böhmig

et al. 2013

American Journal of Transplantation

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The impact of vesicoureteral reflux (VUR) on renal allograft outcomes is debatable, with small cohort studies reporting controversial results. The objective of this retrospective study was to evaluate long-term clinical effects of early VUR in a large cohort of kidney transplant patients. Posttransplantation voiding cystourethrography was used to evaluate 646 consecutive kidney transplant recipients before discharge. The study endpoints included VUR grade, death-censored graft or patient survival, renal function, proteinuria and occurrence of urinary tract infections (UTIs). Of the 646 recipients, 263 (40.7%) were diagnosed with VUR. VUR grade II was most common (19.8%), followed by grades III (10.2%), I (7.9%) and IV (2.8%). VUR was less common in transplantations performed by experienced compared to inexperienced surgeons (36% vs. 48%; p = 0.004). VUR did not affect death-censored graft or patient survival and was not associated with proteinuria or occurrence of UTIs. Patients with VUR had a lower eGFR at 1 year after transplantation than did patients without VUR (60 vs. 52 mL/min/1.73 m 2 ; p = 0.02), although this difference was not observed at 3 and 5 years after transplantation. We conclude that early VUR, a common finding among renal transplant patients, may not have a meaningful impact on longterm transplant outcomes.

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Section: Discussionmentioning

confidence: 99%

Value of Routine Voiding Cystourethrography After Renal Transplantation

Margreiter

Györi

Böhmig

et al. 2013

American Journal of Transplantation

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“…The high prevalence of UTI compared with recurrent UTI may be attributed to the definitions that we used and the long followup. The incidence of UTIs is highly variable in other studies, with ranges between 6% and 86% in some studies 10,17 and from 10% to 98% in another study. 13 This variability of UTIs was attributed to variations in study design, local outbreaks, definitions, and diagnostic criteria.…”

Section: Discussionmentioning

confidence: 88%

“…However, a retrospective analysis of renal transplant recipients found no association between UTI and graft or patient survival. 17 This observational cohort retrospective study involved patients seen at the Hamed Al-Essa Organ Transplant Center of Kuwait to assess the risk factors and outcomes of recurrent UTI in our kidney transplant patients. The prevalence of UTI in our renal transplant recipients reached 86%, but recurrent UTI was only 6.2%.…”

Section: Discussionmentioning

confidence: 99%

Untitled

Tawab¹,

Gheith²,

Otaibi³

et al. 2017

Exp Clin Transplant

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Objectives: Urinary tract infection is the most common type of bacterial infection in kidney transplant procedures, with adverse effects on graft and patient survival. We aimed to evaluate the risk factors of recurrent urinary tract infection in renal transplant recipients and its impact on patient and graft survival. Materials and Methods: In a cohort of 1019 patients who were transplanted between 2000 and 2010 at Hamed Al-Essa Organ Transplant Center in Kuwait, 86% developed at least 1 episode of urinary tract infection, with only 6.2% of patients having recurrent infections. We compared patients with recurrent urinary tract infections (group 1) with those who had no recurrence (group 2) regarding their risk factors. Results: Patients in group 1 were significantly younger than those in group 2 (34.9 ± 23 vs 42.8 ± 16 y; P < .001), with female preponderance (P < .001). The percentage of patients with thymoglobulin induction (21.5%) was significantly higher in group 1. Patients with pretransplant urologic problems experienced significantly more recurrent urinary tract infections (P < .001). Hepatitis C infections were significantly more prevalent among group 1 (10.8% vs 3.8%; P = .008). Long-term graft outcome (functioning and failed) were 78.5% and 21.5% in group 1 versus 85.1% and 13.9% in group 2 (P = .18). Patient outcomes (living and deceased donors) were 98.4% and 1.6% in group 1 versus 95.7% and 4.3% in group 2 (P = .187). Conclusions: Adult females, thymoglobulin induction, pretransplant urologic problems, and hepatitis C infection were the risk factors of recurrent urinary tract infection among our renal transplant patients. However, recurrence did not adversely affect graft or patient survival.

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“…Using prophylaxis as a preventive treatment for UTI, it occurs in first months in high incidence in kidney recipients (20). Dupont et al highlighted the worse impact of UTI on graft and patient's survival in kidney transplant (26). In another investigation, prevention and treatment of the infection is very important in the success of kidney transplantation (27).…”

Section: Discussionmentioning

confidence: 99%

Does early removal of Foley’s catheter have any influence on infection of recipient post renal transplantation? Is it safe? A randomized clinical trial

Zomorrodi¹,

Kakei²,

Bagheri³

et al. 2018

J Nephropathol

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Background: Kidney transplant is a fair option for treatment of a chronic renal failure. Although the outcome and results of kidney transplant are good, it may be associated with some complications. One of the important complications is urinary infection. Objectives: The aim of this study was to investigate the role of early removal of the catheter in renal transplant patients on the reduction of urinary tract infections. Patients and Methods:This study was conducted as a clinical trial. Around 88 transplanted patients were enrolled and randomly divided into two groups. In the first group, the patients were taken 3 days after the transplant, and in the second group, patients were removed 7 days after the Foley catcher transplant. Urine culture was performed on two occasions. Then, the patients' data were analyzed using SPSS version 20. Results: After examination of urine and analyzing the results with t test, it showed that infection of urine in the time of removal of urethral catheter was lower than 7 days after removing urethral catheter (P < 0.05). In patients in whom catheter of urethral had been removed 3 days after the operation, approximately urinary tract infection (UTI) was 50% less than those in whom urethral catheter was removed 7 days after the operation. Conclusions: Early removal of catheter has fundamental effects on UTI after kidney transplant and it seems that early removal of urethral catheter may be safe and reasonable in renal transplant of the recipient patient.

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Infection and chronic allograft dysfunction

Cited by 26 publications

References 106 publications

Value of Routine Voiding Cystourethrography After Renal Transplantation

Value of Routine Voiding Cystourethrography After Renal Transplantation

Untitled

Does early removal of Foley’s catheter have any influence on infection of recipient post renal transplantation? Is it safe? A randomized clinical trial

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