Infection and infectivity: Utility of rapid antigen tests for the diagnosis of COVID-19

Abstract

Detection of SARS-CoV-2 proteins is commercially available in the form of lateral-flow rapid antigen test for the point-of-care diagnosis of COVID-19. This platform has been validated for symptomatic and asymptomatic individuals, for diagnosis or screening, and as part of single or sequential diagnostic strategies. Although in general less sensitive than amplification techniques, antigen tests may be particularly valid during the first days of symptoms and to detect individuals with greater viral load, thereby with enhanced chances of viral transmission. The simplicity of antigen tests make them very suitable to discard infection in settings with low pretest probability, and to detect infection in case of higher chances of having COVID-19.

Fine-Tuning the Odds in Bayesian Networks

“…Peng and Ding [2005] propose an iterative proportional fitting procedure (IPFP) to minimize the KL-divergence distance for a set of constraints. Ripoll and Leonelli [2022] efficiently compute the derivatives of sensitivity functions to select the most relevant parameters to a query, yet they limit to single parameter variation.…”